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Tubgcp2 tubulin, gamma complex component 2 [ Mus musculus (house mouse) ]

Gene ID: 74237, updated on 11-Apr-2024

Summary

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Official Symbol
Tubgcp2provided by MGI
Official Full Name
tubulin, gamma complex component 2provided by MGI
Primary source
MGI:MGI:1921487
See related
Ensembl:ENSMUSG00000025474 AllianceGenome:MGI:1921487
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
1700022B05Rik
Summary
Predicted to enable gamma-tubulin binding activity. Predicted to contribute to microtubule minus-end binding activity. Predicted to be involved in several processes, including meiotic cell cycle; microtubule cytoskeleton organization; and nervous system development. Predicted to be located in microtubule organizing center and nucleoplasm. Predicted to be part of gamma-tubulin small complex. Predicted to be active in centrosome and equatorial microtubule organizing center. Is expressed in cerebral cortex; cerebral cortex ventricular layer; and cortical plate. Orthologous to human TUBGCP2 (tubulin gamma complex associated protein 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis adult (RPKM 22.2), limb E14.5 (RPKM 20.2) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Tubgcp2 in Genome Data Viewer
Location:
7 F4; 7 84.98 cM
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (139575868..139616587, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (139995955..140036674, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene predicted gene 16201 Neighboring gene sperm flagellar 1 like Neighboring gene a disintegrin and metallopeptidase domain 8 Neighboring gene STARR-seq mESC enhancer starr_20441 Neighboring gene microRNA 7062 Neighboring gene STARR-seq mESC enhancer starr_20442 Neighboring gene STARR-positive B cell enhancer ABC_E6615 Neighboring gene STARR-positive B cell enhancer ABC_E8219 Neighboring gene zinc finger protein 511 Neighboring gene VISTA enhancer mm1489 Neighboring gene msh homeobox 3 Neighboring gene STARR-seq mESC enhancer starr_20446 Neighboring gene calcyon neuron-specific vesicular protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The centrosome protein AKNA regulates neurogenesis via microtubule organization. Camargo Ortega G, et al. Nature, 2019 Mar. PMID 30787442
  2. Dynamin-1 co-associates with native mouse brain BKCa channels: proteomics analysis of synaptic protein complexes. Gorini G, et al. FEBS Lett, 2010 Mar 5. PMID 20114047, Free PMC Article
  3. The E3 ubiquitin ligases, HUWE1 and NEDD4-1, are involved in the post-translational regulation of the ABCG1 and ABCG4 lipid transporters. Aleidi SM, et al. J Biol Chem, 2015 Oct 2. PMID 26296893, Free PMC Article
  4. The level of the transcription factor Pax6 is essential for controlling the balance between neural stem cell self-renewal and neurogenesis. Sansom SN, et al. PLoS Genet, 2009 Jun. PMID 19521500, Free PMC Article
  5. Transcription factor Foxp3 and its protein partners form a complex regulatory network. Rudra D, et al. Nat Immunol, 2012 Oct. PMID 22922362, Free PMC Article

See all (29) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables gamma-tubulin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
contributes_to microtubule minus-end binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in brain development ISO
Inferred from Sequence Orthology
more info
  
involved_in cytoplasmic microtubule organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in meiotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in microtubule cytoskeleton organization IEA
Inferred from Electronic Annotation
more info
  
involved_in microtubule nucleation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in neuron migration ISO
Inferred from Sequence Orthology
more info
  
involved_in spindle assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in centrosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in centrosome ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
is_active_in equatorial microtubule organizing center IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of gamma-tubulin complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in microtubule IEA
Inferred from Electronic Annotation
more info
  
located_in microtubule organizing center ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in spindle pole IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
gamma-tubulin complex component 2
Names
GCP-2
tubulin, gamma complex associated protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001286007.1 → NP_001272936.1  gamma-tubulin complex component 2 isoform a

    See identical proteins and their annotated locations for NP_001272936.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a). Variants 1 and 2 both encode the same isoform (a).
    Source sequence(s)
    AC107822, AK006233, AK146771, BY234488
    Consensus CDS
    CCDS21960.1
    UniProtKB/Swiss-Prot
    G5E859, Q921G8
    UniProtKB/TrEMBL
    Q3UIT6
    Related
    ENSMUSP00000147329.2, ENSMUST00000211638.2
    Conserved Domains (1) summary
    pfam04130
    Location:220 → 738
    Spc97_Spc98; Spc97 / Spc98 family

  2. NM_001286009.1 → NP_001272938.1  gamma-tubulin complex component 2 isoform b

    See identical proteins and their annotated locations for NP_001272938.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 3' UTR and coding region compared to variant 1. The resulting isoform (b) has a shorter and distinct C-terminus compared to isoform a.
    Source sequence(s)
    AK045084, BY234488
    UniProtKB/TrEMBL
    Q8BZZ0
    Related
    ENSMUST00000211186.2
    Conserved Domains (1) summary
    pfam04130
    Location:220 → 738
    Spc97_Spc98; Spc97 / Spc98 family

  3. NM_001286011.1 → NP_001272940.1  gamma-tubulin complex component 2 isoform c

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks an alternate exon and uses a downstream start codon compared to variant 1. The resulting isoform (c) is shorter at the N-terminus compared to isoform a.
    Source sequence(s)
    AC107822, AK006233, AK146771, BY254870
    UniProtKB/TrEMBL
    Q3UIT6
    Conserved Domains (2) summary
    pfam04130
    Location:214 → 573
    Spc97_Spc98; Spc97 / Spc98 family
    pfam17681
    Location:1 → 211
    GCP_N_terminal; Gamma tubulin complex component N-terminal

  4. NM_133755.2 → NP_598516.2  gamma-tubulin complex component 2 isoform a

    See identical proteins and their annotated locations for NP_598516.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same isoform (a).
    Source sequence(s)
    AK006233, AK146771, BY254870
    Consensus CDS
    CCDS21960.1
    UniProtKB/Swiss-Prot
    G5E859, Q921G8
    UniProtKB/TrEMBL
    Q3UIT6
    Related
    ENSMUSP00000026547.8, ENSMUST00000026547.9
    Conserved Domains (1) summary
    pfam04130
    Location:220 → 738
    Spc97_Spc98; Spc97 / Spc98 family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    139575868..139616587 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030243026.1 → XP_030098886.1  gamma-tubulin complex component 2 isoform X1

    Conserved Domains (2) summary
    pfam04130
    Location:240 → 599
    Spc97_Spc98; Spc97 / Spc98 family
    pfam17681
    Location:6 → 237
    GCP_N_terminal; Gamma tubulin complex component N-terminal

  2. XM_036153497.1 → XP_036009390.1  gamma-tubulin complex component 2 isoform X1

    Conserved Domains (2) summary
    pfam04130
    Location:240 → 599
    Spc97_Spc98; Spc97 / Spc98 family
    pfam17681
    Location:6 → 237
    GCP_N_terminal; Gamma tubulin complex component N-terminal

  3. XM_036153498.1 → XP_036009391.1  gamma-tubulin complex component 2 isoform X2

    Conserved Domains (2) summary
    pfam04130
    Location:214 → 573
    Spc97_Spc98; Spc97 / Spc98 family
    pfam17681
    Location:1 → 211
    GCP_N_terminal; Gamma tubulin complex component N-terminal

  4. XM_011249861.4 → XP_011248163.1  gamma-tubulin complex component 2 isoform X1

    Conserved Domains (2) summary
    pfam04130
    Location:240 → 599
    Spc97_Spc98; Spc97 / Spc98 family
    pfam17681
    Location:6 → 237
    GCP_N_terminal; Gamma tubulin complex component N-terminal

  5. XM_030243027.2 → XP_030098887.1  gamma-tubulin complex component 2 isoform X2

    Conserved Domains (2) summary
    pfam04130
    Location:214 → 573
    Spc97_Spc98; Spc97 / Spc98 family
    pfam17681
    Location:1 → 211
    GCP_N_terminal; Gamma tubulin complex component N-terminal
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q921G8.2 GenPept UniProtKB/Swiss-Prot:Q921G8

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