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Paqr8 progestin and adipoQ receptor family member VIII [ Mus musculus (house mouse) ]

Gene ID: 74229, updated on 11-Apr-2024

Summary

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Official Symbol
Paqr8provided by MGI
Official Full Name
progestin and adipoQ receptor family member VIIIprovided by MGI
Primary source
MGI:MGI:1921479
See related
Ensembl:ENSMUSG00000025931 AllianceGenome:MGI:1921479
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
1700019B16Rik; 3110001D06Rik
Summary
Predicted to enable steroid binding activity and steroid hormone receptor activity. Predicted to be involved in response to steroid hormone. Predicted to act upstream of or within oogenesis. Predicted to be located in Golgi apparatus. Predicted to be active in plasma membrane. Orthologous to human PAQR8 (progestin and adipoQ receptor family member 8). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in cerebellum adult (RPKM 28.5), adrenal adult (RPKM 18.6) and 15 other tissues See more
Orthologs
human all
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Genomic context

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Location:
1 A4; 1 6.5 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (20960772..21009874)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (20890548..20939650)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 24723 Neighboring gene STARR-seq mESC enhancer starr_00392 Neighboring gene RIKEN cDNA 6720483E21 gene Neighboring gene STARR-seq mESC enhancer starr_00394 Neighboring gene STARR-seq mESC enhancer starr_00395 Neighboring gene predicted gene, 24171 Neighboring gene STARR-positive B cell enhancer mm9_chr1:20929159-20929460 Neighboring gene predicted gene, 51618 Neighboring gene STARR-seq mESC enhancer starr_00396 Neighboring gene EF-hand domain (C-terminal) containing 1 Neighboring gene STARR-seq mESC enhancer starr_00397 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:20985434-20985617 Neighboring gene translocating chain-associating membrane protein 2 Neighboring gene STARR-positive B cell enhancer mm9_chr1:21030259-21030560

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. PAQR8 promotes breast cancer recurrence and confers resistance to multiple therapies. Chen S, et al. Breast Cancer Res, 2023 Jan 3. PMID 36597146, Free PMC Article
  2. Functional Analysis of Mmd2 and Related PAQR Genes During Sex Determination in Mice. Zhao L, et al. Sex Dev, 2022. PMID 35306493
  3. Genome-Wide Off-Target Analysis in CRISPR-Cas9 Modified Mice and Their Offspring. Dong Y, et al. G3 (Bethesda), 2019 Nov 5. PMID 31492696, Free PMC Article
  4. Progesterone-facilitated lordosis of estradiol-primed mice is attenuated by knocking down expression of membrane progestin receptors in the midbrain. Frye CA, et al. Steroids, 2014 Mar. PMID 24269738, Free PMC Article
  5. A novel gene in the chromosomal region for juvenile myoclonic epilepsy on 6p12 encodes a brain-specific lysosomal membrane protein. Suzuki T, et al. Biochem Biophys Res Commun, 2001 Nov 2. PMID 11676489

See all (25) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Functional Analysis of Mmd2 and Related PAQR Genes During Sex Determination in Mice.
    Title: Functional Analysis of Mmd2 and Related PAQR Genes During Sex Determination in Mice.
  2. PAQR8 promotes breast cancer recurrence and confers resistance to multiple therapies.
    Title: PAQR8 promotes breast cancer recurrence and confers resistance to multiple therapies.
  3. Paqr7 and Paqr8 are expressed in the midbrain ventral tegmental area of proestrous mice.
    Title: Progesterone-facilitated lordosis of estradiol-primed mice is attenuated by knocking down expression of membrane progestin receptors in the midbrain.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables lipid binding IEA
Inferred from Electronic Annotation
more info
  
enables nuclear steroid receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables steroid binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within cell differentiation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within multicellular organism development IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within oogenesis IEA
Inferred from Electronic Annotation
more info
  
involved_in response to steroid hormone IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
membrane progestin receptor beta
Names
lysosomal membrane protein in brain 1
mPR beta
membrane progesterone P4 receptor beta
membrane progesterone receptor beta
progesterone and adipoQ receptor family member 8
progestin and adipoQ receptor family member 8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001355122.1 → NP_001342051.1  membrane progestin receptor beta

    Status: VALIDATED

    Source sequence(s)
    AC156980
    Consensus CDS
    CCDS14844.1
    UniProtKB/Swiss-Prot
    Q3UHI5, Q80ZE5, Q8C891, Q8CCW9, Q9DA71
    Related
    ENSMUSP00000069127.8, ENSMUST00000068880.14
    Conserved Domains (1) summary
    pfam03006
    Location:70 → 297
    HlyIII; Haemolysin-III related

  2. NM_028829.4 → NP_083105.3  membrane progestin receptor beta

    See identical proteins and their annotated locations for NP_083105.3

    Status: VALIDATED

    Source sequence(s)
    AI847259, AK147376, BC059813, BY151331
    Consensus CDS
    CCDS14844.1
    UniProtKB/Swiss-Prot
    Q3UHI5, Q80ZE5, Q8C891, Q8CCW9, Q9DA71
    Related
    ENSMUSP00000141054.2, ENSMUST00000189400.7
    Conserved Domains (1) summary
    pfam03006
    Location:70 → 297
    HlyIII; Haemolysin-III related

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    20960772..21009874
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030243207.2 → XP_030099067.1  membrane progestin receptor beta isoform X1

    UniProtKB/Swiss-Prot
    Q3UHI5, Q80ZE5, Q8C891, Q8CCW9, Q9DA71
    Conserved Domains (1) summary
    pfam03006
    Location:70 → 297
    HlyIII; Haemolysin-III related
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q80ZE5.2 GenPept UniProtKB/Swiss-Prot:Q80ZE5

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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