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Acsl3 acyl-CoA synthetase long-chain family member 3 [ Mus musculus (house mouse) ]

Gene ID: 74205, updated on 21-Apr-2024

Summary

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Official Symbol
Acsl3provided by MGI
Official Full Name
acyl-CoA synthetase long-chain family member 3provided by MGI
Primary source
MGI:MGI:1921455
See related
Ensembl:ENSMUSG00000032883 AllianceGenome:MGI:1921455
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Acs3; Facl3; LACS 3; Pro2194; 2610510B12Rik
Summary
Predicted to enable arachidonate-CoA ligase activity; protein domain specific binding activity; and protein kinase binding activity. Predicted to be involved in several processes, including fatty acid metabolic process; positive regulation of phosphatidylcholine biosynthetic process; and positive regulation of transport. Predicted to act upstream of or within fatty acid metabolic process. Predicted to be located in Golgi apparatus and perinuclear region of cytoplasm. Predicted to be active in endoplasmic reticulum; lipid droplet; and plasma membrane. Is expressed in several structures, including alimentary system; brain; genitourinary system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in asthma; breast cancer; and prostate cancer. Orthologous to human ACSL3 (acyl-CoA synthetase long chain family member 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in cortex adult (RPKM 21.5), frontal lobe adult (RPKM 18.3) and 25 other tissues See more
Orthologs
human all
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Genomic context

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Location:
1 C4; 1 40.84 cM
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (78635600..78685462)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (78657825..78707743)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene monoacylglycerol O-acyltransferase 1 Neighboring gene predicted gene, 39665 Neighboring gene RIKEN cDNA 5730419F03 gene Neighboring gene STARR-seq mESC enhancer starr_01430 Neighboring gene STARR-seq mESC enhancer starr_01431 Neighboring gene predicted gene, 57683 Neighboring gene STARR-seq mESC enhancer starr_01433 Neighboring gene STARR-positive B cell enhancer ABC_E5775 Neighboring gene UTP14B small subunit processome component Neighboring gene predicted gene, 51635 Neighboring gene predicted gene, 38631 Neighboring gene predicted gene, 33693 Neighboring gene STARR-seq mESC enhancer starr_01434 Neighboring gene heterogeneous nuclear ribonucleoprotein R pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Rab18 binds PLIN2 and ACSL3 to mediate lipid droplet dynamics. Deng Y, et al. Biochim Biophys Acta Mol Cell Biol Lipids, 2021 Jul. PMID 33713834
  2. Suppression of long chain acyl-CoA synthetase 3 decreases hepatic de novo fatty acid synthesis through decreased transcriptional activity. Bu SY, et al. J Biol Chem, 2009 Oct 30. PMID 19737935, Free PMC Article
  3. ACSL3-PAI-1 signaling axis mediates tumor-stroma cross-talk promoting pancreatic cancer progression. Rossi Sebastiano M, et al. Sci Adv, 2020 Oct. PMID 33127675, Free PMC Article
  4. Fatty Acid Oxidation Mediated by Acyl-CoA Synthetase Long Chain 3 Is Required for Mutant KRAS Lung Tumorigenesis. Padanad MS, et al. Cell Rep, 2016 Aug 9. PMID 27477280, Free PMC Article
  5. Mouse very long-chain Acyl-CoA synthetase 3/fatty acid transport protein 3 catalyzes fatty acid activation but not fatty acid transport in MA-10 cells. Pei Z, et al. J Biol Chem, 2004 Dec 24. PMID 15469937

See all (35) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. ACSL3-PAI-1 signaling axis mediates tumor-stroma cross-talk promoting pancreatic cancer progression.
    Title: ACSL3-PAI-1 signaling axis mediates tumor-stroma cross-talk promoting pancreatic cancer progression.
  2. Rab18 binds PLIN2 and ACSL3 to mediate lipid droplet dynamics.
    Title: Rab18 binds PLIN2 and ACSL3 to mediate lipid droplet dynamics.
  3. The ACSL3-LPIAT1 signaling drives prostaglandin synthesis in non-small cell lung cancer.
    Title: The ACSL3-LPIAT1 signaling drives prostaglandin synthesis in non-small cell lung cancer.
  4. ACSL3 expression is up-regulated in ob/ob mice and mice fed a high sucrose diet
    Title: Suppression of long chain acyl-CoA synthetase 3 decreases hepatic de novo fatty acid synthesis through decreased transcriptional activity.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (3) 
  • Endonuclease-mediated (6) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables arachidonate-CoA ligase activity ISO
Inferred from Sequence Orthology
more info
  
enables butyrate-CoA ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables long-chain fatty acid-CoA ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables long-chain fatty acid-CoA ligase activity ISO
Inferred from Sequence Orthology
more info
  
enables medium-chain fatty acid-CoA ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein domain specific binding ISO
Inferred from Sequence Orthology
more info
  
enables protein kinase binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in fatty acid biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within fatty acid metabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within lipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of long-chain fatty acid import into cell ISO
Inferred from Sequence Orthology
more info
  
involved_in long-chain fatty acid metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in long-chain fatty acid metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in long-chain fatty-acyl-CoA metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in neuron differentiation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of Golgi to plasma membrane protein transport ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of phosphatidylcholine biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of secretion ISO
Inferred from Sequence Orthology
more info
  
involved_in very-low-density lipoprotein particle assembly ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
located_in intracellular membrane-bounded organelle IEA
Inferred from Electronic Annotation
more info
  
is_active_in lipid droplet IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in lipid droplet ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrial outer membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in peroxisome IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
fatty acid CoA ligase Acsl3
Names
arachidonate--CoA ligase
fatty acid Coenzyme A ligase, long chain 3
long-chain acyl-CoA synthetase 3
long-chain-fatty-acid--CoA ligase 3
medium-chain acyl-CoA ligase Acsl3
NP_001028778.2
NP_001129694.1
NP_001396004.1
NP_001396005.1
NP_001396006.1
NP_001396007.1
NP_001396008.1
NP_083093.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001033606.3 → NP_001028778.2  fatty acid CoA ligase Acsl3 isoform a

    See identical proteins and their annotated locations for NP_001028778.2

    Status: VALIDATED

    Source sequence(s)
    AC156613
    Consensus CDS
    CCDS15087.1
    UniProtKB/Swiss-Prot
    Q8K1J7, Q9CZW4
    Related
    ENSMUSP00000121695.2, ENSMUST00000142704.8
    Conserved Domains (1) summary
    PLN02387
    Location:30 → 717
    PLN02387; long-chain-fatty-acid-CoA ligase family protein

  2. NM_001136222.2 → NP_001129694.1  fatty acid CoA ligase Acsl3 isoform b

    Status: VALIDATED

    Source sequence(s)
    AC156613
    Consensus CDS
    CCDS48295.1
    UniProtKB/TrEMBL
    E9PUC2
    Related
    ENSMUSP00000117952.2, ENSMUST00000134566.8
    Conserved Domains (1) summary
    cd05927
    Location:2 → 565
    LC-FACS_euk; Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS)

  3. NM_001409075.1 → NP_001396004.1  fatty acid CoA ligase Acsl3 isoform c

    Status: VALIDATED

    Source sequence(s)
    AC156613

  4. NM_001409076.1 → NP_001396005.1  fatty acid CoA ligase Acsl3 isoform c

    Status: VALIDATED

    Source sequence(s)
    AC156613

  5. NM_001409077.1 → NP_001396006.1  fatty acid CoA ligase Acsl3 isoform a

    Status: VALIDATED

    Source sequence(s)
    AC156613
    UniProtKB/Swiss-Prot
    Q8K1J7, Q9CZW4

  6. NM_001409078.1 → NP_001396007.1  fatty acid CoA ligase Acsl3 isoform a

    Status: VALIDATED

    Source sequence(s)
    AC156613
    UniProtKB/Swiss-Prot
    Q8K1J7, Q9CZW4

  7. NM_001409079.1 → NP_001396008.1  fatty acid CoA ligase Acsl3 isoform b

    Status: VALIDATED

    Source sequence(s)
    AC156613
    UniProtKB/TrEMBL
    E9PUC2

  8. NM_028817.4 → NP_083093.2  fatty acid CoA ligase Acsl3 isoform a

    See identical proteins and their annotated locations for NP_083093.2

    Status: VALIDATED

    Source sequence(s)
    AC156613
    Consensus CDS
    CCDS15087.1
    UniProtKB/Swiss-Prot
    Q8K1J7, Q9CZW4
    Related
    ENSMUSP00000045291.9, ENSMUST00000035779.15
    Conserved Domains (1) summary
    PLN02387
    Location:30 → 717
    PLN02387; long-chain-fatty-acid-CoA ligase family protein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    78635600..78685462
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9CZW4.2 GenPept UniProtKB/Swiss-Prot:Q9CZW4

Gene LinkOut

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