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Fblim1 filamin binding LIM protein 1 [ Mus musculus (house mouse) ]

Gene ID: 74202, updated on 5-Mar-2024

Summary

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Official Symbol
Fblim1provided by MGI
Official Full Name
filamin binding LIM protein 1provided by MGI
Primary source
MGI:MGI:1921452
See related
Ensembl:ENSMUSG00000006219 AllianceGenome:MGI:1921452
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Cal; Gt10; Fblp1; migfilin; migfilin(s); 2410043F08Rik
Summary
Predicted to enable filamin binding activity. Predicted to be involved in cell-cell adhesion and regulation of integrin activation. Predicted to act upstream of or within cell adhesion and regulation of cell shape. Predicted to be located in several cellular components, including cell junction; cell periphery; and fibrillar center. Predicted to be active in focal adhesion and stress fiber. Is expressed in several structures, including central nervous system; early conceptus; reproductive system; sensory organ; and urinary system. Orthologous to human FBLIM1 (filamin binding LIM protein 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in heart adult (RPKM 66.2), bladder adult (RPKM 34.1) and 17 other tissues See more
Orthologs
human all
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Genomic context

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Location:
4 D3; 4 74.64 cM
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (141303373..141333351, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (141576062..141606052, complement)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene spen family transcription repressor Neighboring gene RIKEN cDNA B330016D10 gene Neighboring gene STARR-positive B cell enhancer ABC_E6250 Neighboring gene predicted gene 4123 Neighboring gene STARR-positive B cell enhancer ABC_E6251 Neighboring gene STARR-positive B cell enhancer ABC_E6252 Neighboring gene STARR-seq mESC enhancer starr_11919 Neighboring gene STARR-seq mESC enhancer starr_11920 Neighboring gene STARR-seq mESC enhancer starr_11921 Neighboring gene STARR-positive B cell enhancer ABC_E1289 Neighboring gene STARR-positive B cell enhancer ABC_E1662 Neighboring gene STARR-seq mESC enhancer starr_11923 Neighboring gene expressed sequence AI507597 Neighboring gene transmembrane protein 82 Neighboring gene solute carrier family 25, member 34

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. In vivo cardiac role of migfilin during experimental pressure overload. Haubner BJ, et al. Cardiovasc Res, 2015 Jun 1. PMID 25852081
  2. Critical role of filamin-binding LIM protein 1 (FBLP-1)/migfilin in regulation of bone remodeling. Xiao G, et al. J Biol Chem, 2012 Jun 15. PMID 22556421, Free PMC Article
  3. Possible involvement of a cell adhesion molecule, Migfilin, in brain development and pathogenesis of autism spectrum disorders. Ishizuka K, et al. J Neurosci Res, 2018 May. PMID 29114925
  4. A novel LIM protein Cal promotes cardiac differentiation by association with CSX/NKX2-5. Akazawa H, et al. J Cell Biol, 2004 Feb 2. PMID 14757752, Free PMC Article
  5. A gene trap approach in mouse embryonic stem cells: the lacZ reported is activated by splicing, reflects endogenous gene expression, and is mutagenic in mice. Skarnes WC, et al. Genes Dev, 1992 Jun. PMID 1592261

See all (41) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Findings indicate that tightly regulated expression of migfilin is essential for neuronal development and that FBLIM1 disruption may be related to the phenotypes associated with ASD and related neurodevelopmental disorders.
    Title: Possible involvement of a cell adhesion molecule, Migfilin, in brain development and pathogenesis of autism spectrum disorders.
  2. Suggest migfilin regulates cardiac hypertrophy in transverse aortic constriction.
    Title: In vivo cardiac role of migfilin during experimental pressure overload.
  3. C-terminal LIM domains of migfilin dictate its focal adhesion localization, and these domains mediate an interaction with kindlin in vitro and in cells, demonstrating that kindlin is important for normal migfilin dynamics.
    Title: Kindlin binds migfilin tandem LIM domains and regulates migfilin focal adhesion localization and recruitment dynamics.
  4. results identify FBLP-1 as a key regulator of bone homeostasis and suggest that FBLP-1 functions in this process through modulating both the intrinsic properties of OB/BMSCs (i.e., BMSC-extracellular matrix adhesion and migration
    Title: Critical role of filamin-binding LIM protein 1 (FBLP-1)/migfilin in regulation of bone remodeling.
  5. This study demonistrated that a molecular mechanism whereby FlnA loss impaired G2 to M phase entry, leading to cell cycle prolongation, compromised neural progenitor proliferation, and reduced brain size.
    Title: Filamin a regulates neural progenitor proliferation and cortical size through Wee1-dependent Cdk1 phosphorylation.
  6. The findings indicate that the roles of migfilin are functionally redundant during mouse development and tissue homeostasis.
    Title: Loss of migfilin expression has no overt consequences on murine development and homeostasis.
  7. analysis of the migfilin-filamin interaction and competition with integrin beta 7 tails
    Title: Structural basis of the migfilin-filamin interaction and competition with integrin beta tails.
  8. results suggest that a novel LIM protein Cal induces cardiomyocyte differentiation through its dynamic intracellular shuttling and association with CSX/NKX2-5
    Title: A novel LIM protein Cal promotes cardiac differentiation by association with CSX/NKX2-5.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (4) 
  • Targeted (3)  1 citation
  • Endonuclease-mediated (7) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables filamin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables filamin binding ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within cell adhesion IEA
Inferred from Electronic Annotation
more info
  
involved_in cell-cell adhesion IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell-cell adhesion ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of cell shape IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of integrin activation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in anchoring junction IEA
Inferred from Electronic Annotation
more info
  
located_in cell junction ISO
Inferred from Sequence Orthology
more info
  
located_in cell periphery ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in fibrillar center ISO
Inferred from Sequence Orthology
more info
  
is_active_in focal adhesion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in focal adhesion ISO
Inferred from Sequence Orthology
more info
  
is_active_in stress fiber IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in stress fiber ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
filamin-binding LIM protein 1
Names
CSX-associated LIM
FBLP-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001163256.2 → NP_001156728.1  filamin-binding LIM protein 1 isoform 1

    See identical proteins and their annotated locations for NP_001156728.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AL670446
    Consensus CDS
    CCDS18876.1
    UniProtKB/Swiss-Prot
    Q3TDK3, Q71FD7, Q99J35
    Related
    ENSMUSP00000101410.2, ENSMUST00000105784.8
    Conserved Domains (3) summary
    cd09357
    Location:305 → 366
    LIM3_Zyxin_like; The third LIM domain of Zyxin-like family
    cd09372
    Location:245 → 297
    LIM2_FBLP-1; The second LIM domain of the filamin-binding LIM protein-1 (FBLP-1)
    cl02475
    Location:181 → 238
    LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

  2. NM_001378958.2 → NP_001365887.1  filamin-binding LIM protein 1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL670446
    UniProtKB/Swiss-Prot
    Q3TDK3, Q71FD7, Q99J35
    Conserved Domains (3) summary
    cd09357
    Location:305 → 366
    LIM3_Zyxin_like; The third LIM domain of Zyxin-like family
    cd09372
    Location:245 → 297
    LIM2_FBLP-1; The second LIM domain of the filamin-binding LIM protein-1 (FBLP-1)
    cl02475
    Location:181 → 238
    LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

  3. NM_001378959.1 → NP_001365888.1  filamin-binding LIM protein 1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL670446
    UniProtKB/Swiss-Prot
    Q3TDK3, Q71FD7, Q99J35
    Related
    ENSMUSP00000006381.5, ENSMUST00000006381.11
    Conserved Domains (3) summary
    cd09357
    Location:305 → 366
    LIM3_Zyxin_like; The third LIM domain of Zyxin-like family
    cd09372
    Location:245 → 297
    LIM2_FBLP-1; The second LIM domain of the filamin-binding LIM protein-1 (FBLP-1)
    cl02475
    Location:181 → 238
    LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

  4. NM_001404640.1 → NP_001391569.1  filamin-binding LIM protein 1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL670446
    UniProtKB/Swiss-Prot
    Q3TDK3, Q71FD7, Q99J35

  5. NM_001404641.1 → NP_001391570.1  filamin-binding LIM protein 1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL670446
    UniProtKB/Swiss-Prot
    Q3TDK3, Q71FD7, Q99J35

  6. NM_001404642.1 → NP_001391571.1  filamin-binding LIM protein 1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL670446

  7. NM_001404643.1 → NP_001391572.1  filamin-binding LIM protein 1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL670446
    UniProtKB/Swiss-Prot
    Q3TDK3, Q71FD7, Q99J35

  8. NM_001404644.1 → NP_001391573.1  filamin-binding LIM protein 1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL670446
    UniProtKB/Swiss-Prot
    Q3TDK3, Q71FD7, Q99J35

  9. NM_133754.6 → NP_598515.3  filamin-binding LIM protein 1 isoform 1

    See identical proteins and their annotated locations for NP_598515.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AL670446
    Consensus CDS
    CCDS18876.1
    UniProtKB/Swiss-Prot
    Q3TDK3, Q71FD7, Q99J35
    Related
    ENSMUSP00000101411.3, ENSMUST00000105785.9
    Conserved Domains (3) summary
    cd09357
    Location:305 → 366
    LIM3_Zyxin_like; The third LIM domain of Zyxin-like family
    cd09372
    Location:245 → 297
    LIM2_FBLP-1; The second LIM domain of the filamin-binding LIM protein-1 (FBLP-1)
    cl02475
    Location:181 → 238
    LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    141303373..141333351 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006539215.4 → XP_006539278.1  filamin-binding LIM protein 1 isoform X2

    See identical proteins and their annotated locations for XP_006539278.1

    UniProtKB/Swiss-Prot
    Q3TDK3, Q71FD7, Q99J35
    Conserved Domains (3) summary
    cd09357
    Location:305 → 366
    LIM3_Zyxin_like; The third LIM domain of Zyxin-like family
    cd09372
    Location:245 → 297
    LIM2_FBLP-1; The second LIM domain of the filamin-binding LIM protein-1 (FBLP-1)
    cl02475
    Location:181 → 238
    LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

  2. XM_006539214.4 → XP_006539277.1  filamin-binding LIM protein 1 isoform X2

    See identical proteins and their annotated locations for XP_006539277.1

    UniProtKB/Swiss-Prot
    Q3TDK3, Q71FD7, Q99J35
    Conserved Domains (3) summary
    cd09357
    Location:305 → 366
    LIM3_Zyxin_like; The third LIM domain of Zyxin-like family
    cd09372
    Location:245 → 297
    LIM2_FBLP-1; The second LIM domain of the filamin-binding LIM protein-1 (FBLP-1)
    cl02475
    Location:181 → 238
    LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

  3. XM_030253841.1 → XP_030109701.1  filamin-binding LIM protein 1 isoform X2

    UniProtKB/Swiss-Prot
    Q3TDK3, Q71FD7, Q99J35
    Conserved Domains (3) summary
    cd09357
    Location:305 → 366
    LIM3_Zyxin_like; The third LIM domain of Zyxin-like family
    cd09372
    Location:245 → 297
    LIM2_FBLP-1; The second LIM domain of the filamin-binding LIM protein-1 (FBLP-1)
    cl02475
    Location:181 → 238
    LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q71FD7.2 GenPept UniProtKB/Swiss-Prot:Q71FD7

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