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Exoc3l4 exocyst complex component 3-like 4 [ Mus musculus (house mouse) ]

Gene ID: 74190, updated on 11-Apr-2024

Summary

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Official Symbol
Exoc3l4provided by MGI
Official Full Name
exocyst complex component 3-like 4provided by MGI
Primary source
MGI:MGI:1921363
See related
Ensembl:ENSMUSG00000021280 AllianceGenome:MGI:1921363
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
1200009I06Rik; 1600013K19Rik
Summary
Predicted to enable SNARE binding activity. Predicted to be involved in exocyst localization and exocytosis. Predicted to be part of exocyst. Orthologous to human EXOC3L4 (exocyst complex component 3 like 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in duodenum adult (RPKM 80.1), small intestine adult (RPKM 54.4) and 8 other tissues See more
Orthologs
human all
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Genomic context

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Location:
12 F1; 12 60.98 cM
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (111383864..111398114)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (111417430..111431680)

Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA A230087F16 gene Neighboring gene CDC42 binding protein kinase beta Neighboring gene LBH domain containing 2 Neighboring gene tumor necrosis factor, alpha-induced protein 2 Neighboring gene predicted gene, 40578 Neighboring gene predicted gene 266

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Mapping the NPHP-JBTS-MKS protein network reveals ciliopathy disease genes and pathways. Sang L, et al. Cell, 2011 May 13. PMID 21565611, Free PMC Article
  2. Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method. Piao Y, et al. Genome Res, 2001 Sep. PMID 11544199, Free PMC Article
  3. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
  4. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article
  5. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables SNARE binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in exocyst localization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in exocytosis IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of exocyst IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
exocyst complex component 3-like protein 4
Names
SEC6-like protein C14orf73 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001289487.1 → NP_001276416.1  exocyst complex component 3-like protein 4

    See identical proteins and their annotated locations for NP_001276416.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2, 3 and 4 encode the same protein.
    Source sequence(s)
    AC122190, AK004674, BC075664, BM247872, BQ032492, BY235568, BY701311
    Consensus CDS
    CCDS26177.1
    UniProtKB/Swiss-Prot
    Q6DIA2, Q80UY5, Q9DAX8
    UniProtKB/TrEMBL
    A0A0R4J0W9
    Conserved Domains (1) summary
    pfam06046
    Location:182 → 708
    Sec6; Exocyst complex component Sec6

  2. NM_001289488.1 → NP_001276417.1  exocyst complex component 3-like protein 4

    See identical proteins and their annotated locations for NP_001276417.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3 and 4 encode the same protein.
    Source sequence(s)
    AK004674, BQ032492, BY701311, CF915432
    Consensus CDS
    CCDS26177.1
    UniProtKB/Swiss-Prot
    Q6DIA2, Q80UY5, Q9DAX8
    UniProtKB/TrEMBL
    A0A0R4J0W9
    Related
    ENSMUSP00000072438.7, ENSMUST00000072646.8
    Conserved Domains (1) summary
    pfam06046
    Location:182 → 708
    Sec6; Exocyst complex component Sec6

  3. NM_001289489.1 → NP_001276418.1  exocyst complex component 3-like protein 4

    See identical proteins and their annotated locations for NP_001276418.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3 and 4 encode the same protein.
    Source sequence(s)
    AC122190
    Consensus CDS
    CCDS26177.1
    UniProtKB/Swiss-Prot
    Q6DIA2, Q80UY5, Q9DAX8
    UniProtKB/TrEMBL
    A0A0R4J0W9
    Related
    ENSMUSP00000152844.2, ENSMUST00000222897.2
    Conserved Domains (1) summary
    pfam06046
    Location:182 → 708
    Sec6; Exocyst complex component Sec6

  4. NM_028807.4 → NP_083083.3  exocyst complex component 3-like protein 4

    See identical proteins and their annotated locations for NP_083083.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3 and 4 encode the same protein.
    Source sequence(s)
    AK004674, BC075664, BQ032492, BY205345, BY701311
    Consensus CDS
    CCDS26177.1
    UniProtKB/Swiss-Prot
    Q6DIA2, Q80UY5, Q9DAX8
    UniProtKB/TrEMBL
    A0A0R4J0W9
    Related
    ENSMUSP00000152337.2, ENSMUST00000223050.2
    Conserved Domains (1) summary
    pfam06046
    Location:182 → 708
    Sec6; Exocyst complex component Sec6

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000078.7 Reference GRCm39 C57BL/6J

    Range
    111383864..111398114
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006516289.2 → XP_006516352.1  exocyst complex component 3-like protein 4 isoform X1

    See identical proteins and their annotated locations for XP_006516352.1

    UniProtKB/Swiss-Prot
    Q6DIA2, Q80UY5, Q9DAX8
    UniProtKB/TrEMBL
    A0A0R4J0W9
    Conserved Domains (1) summary
    pfam06046
    Location:182 → 708
    Sec6; Exocyst complex component Sec6

  2. XM_006516291.5 → XP_006516354.1  exocyst complex component 3-like protein 4 isoform X1

    See identical proteins and their annotated locations for XP_006516354.1

    UniProtKB/Swiss-Prot
    Q6DIA2, Q80UY5, Q9DAX8
    UniProtKB/TrEMBL
    A0A0R4J0W9
    Conserved Domains (1) summary
    pfam06046
    Location:182 → 708
    Sec6; Exocyst complex component Sec6

  3. XM_006516292.5 → XP_006516355.1  exocyst complex component 3-like protein 4 isoform X1

    See identical proteins and their annotated locations for XP_006516355.1

    UniProtKB/Swiss-Prot
    Q6DIA2, Q80UY5, Q9DAX8
    UniProtKB/TrEMBL
    A0A0R4J0W9
    Conserved Domains (1) summary
    pfam06046
    Location:182 → 708
    Sec6; Exocyst complex component Sec6
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6DIA2.2 GenPept UniProtKB/Swiss-Prot:Q6DIA2

Gene LinkOut

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