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Prl8a8 prolactin family 8, subfamily a, member 81 [ Mus musculus (house mouse) ]

Gene ID: 74188, updated on 11-Apr-2024

Summary

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Official Symbol
Prl8a8provided by MGI
Official Full Name
prolactin family 8, subfamily a, member 81provided by MGI
Primary source
MGI:MGI:1921438
See related
Ensembl:ENSMUSG00000021346 AllianceGenome:MGI:1921438
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ghd14; PLP-C3; Prlpc3; PLP-Cgamma; 1600032B14Rik
Summary
Predicted to enable hormone activity and prolactin receptor binding activity. Predicted to be involved in several processes, including positive regulation of lactation; positive regulation of pri-miRNA transcription by RNA polymerase II; and positive regulation of receptor signaling pathway via JAK-STAT. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in extraembryonic component and placenta. Human ortholog(s) of this gene implicated in carotid artery disease. Orthologous to human PRL (prolactin). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Restricted expression toward placenta adult (RPKM 35.6) See more
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Genomic context

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Location:
13 A3.1; 13 12.49 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (27690951..27697200, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (27506968..27513217, complement)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene prolactin family 2, subfamily b, member 1 Neighboring gene predicted gene, 40836 Neighboring gene prolactin family 8, subfamily a, member 6 Neighboring gene prolactin family8, subfamily a, member 9 Neighboring gene prolactin family 8, subfamily a, member 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Plac1 (placenta-specific 1) is essential for normal placental and embryonic development. Jackman SM, et al. Mol Reprod Dev, 2012 Aug. PMID 22729990, Free PMC Article
  2. Assisted reproductive technologies induce temporally specific placental defects and the preeclampsia risk marker sFLT1 in mouse. Vrooman LA, et al. Development, 2020 May 29. PMID 32471820, Free PMC Article
  3. Contribution of Prostaglandin Transporter OATP2A1/SLCO2A1 to Placenta-to-Maternal Hormone Signaling and Labor Induction. Inagaki M, et al. iScience, 2020 May 22. PMID 32408168, Free PMC Article
  4. Deletion of the Syncytin A receptor Ly6e impairs syncytiotrophoblast fusion and placental morphogenesis causing embryonic lethality in mice. Langford MB, et al. Sci Rep, 2018 Mar 2. PMID 29500366, Free PMC Article
  5. NODAL in the uterus is necessary for proper placental development and maintenance of pregnancy. Park CB, et al. Biol Reprod, 2012 Jun. PMID 22378764, Free PMC Article

See all (31) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables hormone activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables prolactin receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in female pregnancy IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mammary gland development IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of cell population proliferation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of lactation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of receptor signaling pathway via JAK-STAT IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in response to nutrient levels IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
prolactin-8A8
Names
PLP-C gamma2
PRL-like protein C3
growth hormone d14
placental prolactin-like protein C3
prolactin-like protein C-gamma

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001311125.1 → NP_001298054.1  prolactin-8A8 isoform 1 precursor

    See identical proteins and their annotated locations for NP_001298054.1

    Status: VALIDATED

    Source sequence(s)
    AK005568, BY035367
    Consensus CDS
    CCDS79173.1
    UniProtKB/Swiss-Prot
    Q8VHE8, Q9DAS4
    UniProtKB/TrEMBL
    A0A0M6L0I6
    Related
    ENSMUSP00000105979.2, ENSMUST00000110350.9
    Conserved Domains (1) summary
    cd10288
    Location:31 → 241
    prolactin_like; Prolactin (PRL or PRL1), chorionic somatomammotropin, and related pituitary gland hormones

  2. NM_001360895.1 → NP_001347824.1  prolactin-8A8 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL590522
    Conserved Domains (1) summary
    cd10288
    Location:69 → 279
    prolactin_like; Prolactin (PRL or PRL1), chorionic somatomammotropin, and related pituitary gland hormones

  3. NM_001360896.1 → NP_001347825.1  prolactin-8A8 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AL590522
    Consensus CDS
    CCDS88431.1
    UniProtKB/TrEMBL
    Q8CFH0
    Related
    ENSMUSP00000153131.2, ENSMUST00000224072.2
    Conserved Domains (1) summary
    cd10288
    Location:68 → 278
    prolactin_like; Prolactin (PRL or PRL1), chorionic somatomammotropin, and related pituitary gland hormones

  4. NM_023741.3 → NP_076230.1  prolactin-8A8 isoform 2 precursor

    See identical proteins and their annotated locations for NP_076230.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region compared to variant 1. The encoded isoform (2) is shorter compared to isoform 1.
    Source sequence(s)
    AL590522
    Consensus CDS
    CCDS26399.1
    UniProtKB/Swiss-Prot
    Q9DAS4
    Related
    ENSMUSP00000018389.4, ENSMUST00000018389.5
    Conserved Domains (1) summary
    cd10288
    Location:30 → 240
    prolactin_like; Prolactin (PRL or PRL1), chorionic somatomammotropin, and related pituitary gland hormones

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    27690951..27697200 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9DAS4.1 GenPept UniProtKB/Swiss-Prot:Q9DAS4

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