Zdhhc16 zinc finger, DHHC domain containing 16 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Zdhhc16provided by MGI
Official Full Name: zinc finger, DHHC domain containing 16provided by MGI
Primary source: MGI:MGI:1921418
See related: Ensembl:ENSMUSG00000025157 AllianceGenome:MGI:1921418
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Aph2; 1500015N03Rik
Summary: Enables palmitoyltransferase activity. Involved in animal organ development; cellular response to DNA damage stimulus; and protein palmitoylation. Predicted to be located in endoplasmic reticulum and membrane. Predicted to be integral component of membrane. Predicted to be active in Golgi apparatus. Is expressed in early conceptus; eye; genitourinary system; heart; and trunk somite. Orthologous to human ZDHHC16 (zinc finger DHHC-type palmitoyltransferase 16). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in limb E14.5 (RPKM 18.4), ovary adult (RPKM 16.7) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 19 C3; 19 35.48 cM

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	19	NC_000085.7 (41921884..41932543)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	19	NC_000085.6 (41933445..41944104)

Chromosome 19 - NC_000085.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Knockout of zDHHC16, a palmitoyltransferase gene is identified as an interacting protein for c-Abl, a non-receptor tyrosine kinase involved in DNA damage response, reproduced most of the defects in DNA damage responses produced by the inhibition of protein palmitoylation.
Title: A potential role for protein palmitoylation and zDHHC16 in DNA damage response.
Aph2 as a critical in vivo regulator of cardiac function and reveal roles for protein palmitoylation in the development of other organs including eyes.
Title: Palmitoyl acyltransferase Aph2 in cardiac function and the development of cardiomyopathy.
Aph2 may be involved in ER stress-induced apoptosis in which c-Abl plays an important role
Title: Aph2, a protein with a zf-DHHC motif, interacts with c-Abl and has pro-apoptotic activity.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (3) 1 citation
Endonuclease-mediated (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables acyltransferase activity	IEA Inferred from Electronic Annotation more info
enables palmitoyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables palmitoyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables palmitoyltransferase activity	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein-cysteine S-palmitoyltransferase activity	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in DNA damage response	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in eye development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in heart development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein palmitoylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein palmitoylation	IDA Inferred from Direct Assay more info	PubMed
involved_in protein palmitoylation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in Golgi apparatus	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: palmitoyltransferase ZDHHC16

Names: Abl-philin 2; ablphilin-2; probable palmitoyltransferase ZDHHC16; zinc finger DHHC domain-containing protein 16

NP_001347605.1

EC 2.3.1.225

NP_001347608.1

EC 2.3.1.225

NP_076229.2

EC 2.3.1.225

XP_006527467.1

EC 2.3.1.225

XP_006527468.1

EC 2.3.1.225

XP_006527469.1

EC 2.3.1.225

XP_006527470.1

EC 2.3.1.225

XP_017173789.1

EC 2.3.1.225

XP_030106976.1

EC 2.3.1.225

XP_030106977.1

EC 2.3.1.225

XP_030106978.1

EC 2.3.1.225

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001360676.1 → NP_001347605.1 palmitoyltransferase ZDHHC16 isoform 1

Status: VALIDATED

Source sequence(s)

AC140193

Conserved Domains (1) summary

pfam01529
Location:156 → 305

DHHC; DHHC palmitoyltransferase
NM_001360679.1 → NP_001347608.1 palmitoyltransferase ZDHHC16 isoform 3

Status: VALIDATED

Source sequence(s)

AC140193

Conserved Domains (1) summary

pfam01529
Location:1 → 109

DHHC; DHHC palmitoyltransferase
NM_023740.3 → NP_076229.2 palmitoyltransferase ZDHHC16 isoform 2

See identical proteins and their annotated locations for NP_076229.2

Status: VALIDATED

Source sequence(s)

AK151505, BY634308, CK619221, DV658063

Consensus CDS

CCDS29817.1

UniProtKB/Swiss-Prot

Q3TI22, Q3UA59, Q91XC5, Q9ESG8

Related

ENSMUSP00000026154.8, ENSMUST00000026154.9

Conserved Domains (1) summary

pfam01529
Location:156 → 289

DHHC; DHHC palmitoyltransferase

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000085.7 Reference GRCm39 C57BL/6J

Range

41921884..41932543

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006527406.4 → XP_006527469.1 palmitoyltransferase ZDHHC16 isoform X4

See identical proteins and their annotated locations for XP_006527469.1

Conserved Domains (1) summary

pfam01529
Location:1 → 125

DHHC; DHHC palmitoyltransferase
XM_006527407.4 → XP_006527470.1 palmitoyltransferase ZDHHC16 isoform X4

See identical proteins and their annotated locations for XP_006527470.1

Conserved Domains (1) summary

pfam01529
Location:1 → 125

DHHC; DHHC palmitoyltransferase
XM_030251118.2 → XP_030106978.1 palmitoyltransferase ZDHHC16 isoform X5

Conserved Domains (1) summary

pfam01529
Location:1 → 109

DHHC; DHHC palmitoyltransferase
XM_017318300.3 → XP_017173789.1 palmitoyltransferase ZDHHC16 isoform X1

Conserved Domains (1) summary

pfam01529
Location:156 → 305

DHHC; DHHC palmitoyltransferase
XM_030251117.2 → XP_030106977.1 palmitoyltransferase ZDHHC16 isoform X2

Conserved Domains (1) summary

pfam01529
Location:156 → 289

DHHC; DHHC palmitoyltransferase
XM_006527404.5 → XP_006527467.1 palmitoyltransferase ZDHHC16 isoform X1

Conserved Domains (1) summary

pfam01529
Location:156 → 305

DHHC; DHHC palmitoyltransferase
XM_030251116.2 → XP_030106976.1 palmitoyltransferase ZDHHC16 isoform X2

Conserved Domains (1) summary

pfam01529
Location:156 → 289

DHHC; DHHC palmitoyltransferase
XM_006527405.5 → XP_006527468.1 palmitoyltransferase ZDHHC16 isoform X3

Conserved Domains (1) summary

cl19890
Location:156 → 194

DHHC; DHHC palmitoyltransferase