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Nudt9 nudix hydrolase 9 [ Mus musculus (house mouse) ]

Gene ID: 74167, updated on 5-Mar-2024

Summary

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Official Symbol
Nudt9provided by MGI
Official Full Name
nudix hydrolase 9provided by MGI
Primary source
MGI:MGI:1921417
See related
Ensembl:ENSMUSG00000029310 AllianceGenome:MGI:1921417
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
ADPR-PPase; 1190002C07Rik
Summary
Enables ADP-ribose diphosphatase activity. Acts upstream of or within ADP catabolic process and IDP catabolic process. Located in mitochondrion. Is expressed in alimentary system; cranium; liver; nervous system; and retina. Orthologous to human NUDT9 (nudix hydrolase 9). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis adult (RPKM 57.6), adrenal adult (RPKM 40.5) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Nudt9 in Genome Data Viewer
Location:
5 E5; 5 50.54 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (104193407..104213244)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (104045538..104065378)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene hydroxysteroid (17-beta) dehydrogenase 13 Neighboring gene hydroxysteroid (17-beta) dehydrogenase 11 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:104436899-104437123 Neighboring gene STARR-seq mESC enhancer starr_13817 Neighboring gene STARR-seq mESC enhancer starr_13818 Neighboring gene STARR-positive B cell enhancer ABC_E2165 Neighboring gene microRNA 5619 Neighboring gene predicted gene, 52783 Neighboring gene secretory calcium-binding phosphoprotein proline-glutamine rich 1 Neighboring gene SPARC-like 1 Neighboring gene STARR-seq mESC enhancer starr_13821 Neighboring gene predicted gene, 26703

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The specific, submicromolar-Km ADP-ribose pyrophosphatase purified from human placenta is enzymically indistinguishable from recombinant NUDT9 protein, including a selectivity for Mn2+ as activating cation and increase in Km for ADP-ribose, both elicited by H2O2. Carloto A, et al. Biochim Biophys Acta, 2006 Oct. PMID 16860484
  2. NUDT9, a member of the Nudix hydrolase family, is an evolutionarily conserved mitochondrial ADP-ribose pyrophosphatase. Perraud AL, et al. J Biol Chem, 2003 Jan 17. PMID 12427752
  3. Cloning, expression and characterisation of a human Nudix hydrolase specific for adenosine 5'-diphosphoribose (ADP-ribose). Lin S, et al. Biochim Biophys Acta, 2002 Jan 31. PMID 11825615
  4. ADP-ribose gating of the calcium-permeable LTRPC2 channel revealed by Nudix motif homology. Perraud AL, et al. Nature, 2001 May 31. PMID 11385575
  5. Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria. Mootha VK, et al. Cell, 2003 Nov 26. PMID 14651853

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. ADP-ribose hydrolysis is catalysed by NDP-sugar/alcohol pyrophosphatases of differing specificity, including a highly specific, low-K(m) ADP-ribose pyrophosphatase.
    Title: The specific, submicromolar-Km ADP-ribose pyrophosphatase purified from human placenta is enzymically indistinguishable from recombinant NUDT9 protein, including a selectivity for Mn2+ as activating cation and increase in Km for ADP-ribose, both elicited by H2O2.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ADP-ribose diphosphatase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables ADP-ribose diphosphatase activity ISO
Inferred from Sequence Orthology
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within ADP catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in cell junction ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrion HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrion TAS
Traceable Author Statement
more info
 PubMed 
located_in nuclear body ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
ADP-ribose pyrophosphatase, mitochondrial
Names
ADP-ribose diphosphatase
ADP-ribose phosphohydrolase
adenosine diphosphoribose pyrophosphatase
nucleoside diphosphate-linked moiety X motif 9
nudix (nucleoside diphosphate linked moiety X)-type motif 9
nudix motif 9
NP_083070.2
XP_006535319.1
XP_006535320.1
XP_030110706.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_028794.4 → NP_083070.2  ADP-ribose pyrophosphatase, mitochondrial

    See identical proteins and their annotated locations for NP_083070.2

    Status: VALIDATED

    Source sequence(s)
    AK158058, AL714024, BY237462
    Consensus CDS
    CCDS19482.1
    UniProtKB/Swiss-Prot
    A2AH31, Q3TZ68, Q8BVU5, Q8K1J4
    Related
    ENSMUSP00000031250.8, ENSMUST00000031250.14
    Conserved Domains (1) summary
    cd03670
    Location:149 → 335
    ADPRase_NUDT9; ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose to AMP and ribose-5-P. Like other members of the Nudix hydrolase superfamily of enzymes, it is thought to require a divalent cation, such as Mg2+, for its activity. It also ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    104193407..104213244
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006535257.5 → XP_006535320.1  ADP-ribose pyrophosphatase, mitochondrial isoform X2

    Conserved Domains (1) summary
    cd03670
    Location:111 → 274
    ADPRase_NUDT9; ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose to AMP and ribose-5-P. Like other members of the Nudix hydrolase superfamily of enzymes, it is thought to require a divalent cation, such as Mg2+, for its activity. It also ...

  2. XM_006535256.5 → XP_006535319.1  ADP-ribose pyrophosphatase, mitochondrial isoform X1

    See identical proteins and their annotated locations for XP_006535319.1

    Conserved Domains (1) summary
    cd03670
    Location:99 → 285
    ADPRase_NUDT9; ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose to AMP and ribose-5-P. Like other members of the Nudix hydrolase superfamily of enzymes, it is thought to require a divalent cation, such as Mg2+, for its activity. It also ...

  3. XM_030254846.2 → XP_030110706.1  ADP-ribose pyrophosphatase, mitochondrial isoform X3

    Conserved Domains (1) summary
    cd03670
    Location:61 → 224
    ADPRase_NUDT9; ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose to AMP and ribose-5-P. Like other members of the Nudix hydrolase superfamily of enzymes, it is thought to require a divalent cation, such as Mg2+, for its activity. It also ...
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BVU5.1 GenPept UniProtKB/Swiss-Prot:Q8BVU5

Gene LinkOut

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