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Zfp946 zinc finger protein 946 [ Mus musculus (house mouse) ]

Gene ID: 74149, updated on 8-Feb-2024

Summary

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Official Symbol
Zfp946provided by MGI
Official Full Name
zinc finger protein 946provided by MGI
Primary source
MGI:MGI:1921399
See related
Ensembl:ENSMUSG00000071266 AllianceGenome:MGI:1921399
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
1300003B13Rik
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in CNS E18 (RPKM 6.0), CNS E14 (RPKM 5.5) and 23 other tissues See more
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Genomic context

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Location:
17 A3.3; 17 11.4 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (22643102..22675670)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (22424182..22456689)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene predicted gene 7072 Neighboring gene predicted gene, 53992 Neighboring gene zinc finger protein 944 Neighboring gene STARR-positive B cell enhancer ABC_E5576 Neighboring gene STARR-seq mESC enhancer starr_42030 Neighboring gene zinc finger protein 758 Neighboring gene STARR-seq mESC enhancer starr_42031 Neighboring gene STARR-positive B cell enhancer ABC_E5577 Neighboring gene STARR-seq mESC enhancer starr_42032 Neighboring gene STARR-seq mESC enhancer starr_42034 Neighboring gene eukaryotic translation elongation factor 1 gamma pseudogene Neighboring gene predicted gene, 30818

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Mouse brain organization revealed through direct genome-scale TF expression analysis. Gray PA, et al. Science, 2004 Dec 24. PMID 15618518
  2. GUDMAP: the genitourinary developmental molecular anatomy project. McMahon AP, et al. J Am Soc Nephrol, 2008 Apr. PMID 18287559
  3. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article
  4. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
  5. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
zinc finger protein 946

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001331195.1 → NP_001318124.1  zinc finger protein 946 isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a).
    Source sequence(s)
    AC122270
    Conserved Domains (3) summary
    COG5048
    Location:262 → 545
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:266 → 286
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:37 → 74
    KRAB; KRAB box

  2. NM_001331196.1 → NP_001318125.1  zinc finger protein 946 isoform a

    Status: VALIDATED

    Source sequence(s)
    AC122270
    Conserved Domains (3) summary
    COG5048
    Location:262 → 545
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:266 → 286
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:37 → 74
    KRAB; KRAB box

  3. NM_001331197.1 → NP_001318126.1  zinc finger protein 946 isoform b

    Status: VALIDATED

    Source sequence(s)
    AC122270
    Consensus CDS
    CCDS50001.1
    UniProtKB/TrEMBL
    F6VWU8
    Related
    ENSMUSP00000132940.2, ENSMUST00000167740.2
    Conserved Domains (3) summary
    COG5048
    Location:240 → 523
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:244 → 264
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:15 → 52
    KRAB; KRAB box

  4. NM_001331198.1 → NP_001318127.1  zinc finger protein 946 isoform b

    Status: VALIDATED

    Source sequence(s)
    AC122270, AK004870, CJ086800
    Consensus CDS
    CCDS50001.1
    UniProtKB/TrEMBL
    F6VWU8
    Related
    ENSMUSP00000086141.7, ENSMUST00000088763.13
    Conserved Domains (3) summary
    COG5048
    Location:240 → 523
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:244 → 264
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:15 → 52
    KRAB; KRAB box

  5. NM_198003.3 → NP_932120.1  zinc finger protein 946 isoform b

    See identical proteins and their annotated locations for NP_932120.1

    Status: VALIDATED

    Source sequence(s)
    AC122270
    Consensus CDS
    CCDS50001.1
    UniProtKB/TrEMBL
    F6VWU8
    Related
    ENSMUSP00000113244.2, ENSMUST00000120222.8
    Conserved Domains (3) summary
    COG5048
    Location:240 → 523
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:244 → 264
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:15 → 52
    KRAB; KRAB box

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    22643102..22675670
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036160815.1 → XP_036016708.1  zinc finger protein 946 isoform X1

    Conserved Domains (3) summary
    COG5048
    Location:262 → 545
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:266 → 286
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:37 → 74
    KRAB; KRAB box

  2. XM_017317692.3 → XP_017173181.1  zinc finger protein 946 isoform X2

    UniProtKB/TrEMBL
    F6VWU8
    Conserved Domains (3) summary
    COG5048
    Location:240 → 523
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:244 → 264
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:15 → 52
    KRAB; KRAB box

  3. XM_030250109.2 → XP_030105969.1  zinc finger protein 946 isoform X1

    Conserved Domains (3) summary
    COG5048
    Location:262 → 545
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:266 → 286
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:37 → 74
    KRAB; KRAB box

  4. XM_017317693.3 → XP_017173182.1  zinc finger protein 946 isoform X2

    UniProtKB/TrEMBL
    F6VWU8
    Conserved Domains (3) summary
    COG5048
    Location:240 → 523
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:244 → 264
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:15 → 52
    KRAB; KRAB box

  5. XM_030250110.2 → XP_030105970.1  zinc finger protein 946 isoform X1

    Conserved Domains (3) summary
    COG5048
    Location:262 → 545
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:266 → 286
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:37 → 74
    KRAB; KRAB box
Nucleotide Protein Strain
Heading Accession and Version

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