F13a1 coagulation factor XIII, A1 subunit [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: F13a1provided by MGI
Official Full Name: coagulation factor XIII, A1 subunitprovided by MGI
Primary source: MGI:MGI:1921395
See related: Ensembl:ENSMUSG00000039109 AllianceGenome:MGI:1921395
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: F13a; 1200014I03Rik
Summary: This gene encodes subunit A of the coagulation factor XIII that catalyzes the final step of the blood coagulation pathway. The encoded protein associates with subunit B to form a heterotetrameric proenzyme that undergoes thrombin-mediated proteolysis to generate active factor XIIIa. The transglutaminase activity of factor XIIIa is required for the calcium-dependent crosslinking of fibrin, leading to the formation of a clot. Mice lacking the encoded protein display impaired reproduction and reduced survival due to bleeding episodes, hematothorax, hematoperitoneum and subcutaneous hemorrhage. Additionally, mice lacking the encoded protein exhibit impaired wound healing and inadequate healing of myocardial infarction. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]
Expression: Broad expression in bladder adult (RPKM 12.1), mammary gland adult (RPKM 11.7) and 17 other tissues See more
Orthologs: human all
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Genomic context

Location:: 13 A3.3; 13 14.44 cM

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	13	NC_000079.7 (37051150..37234220, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	13	NC_000079.6 (36867178..37050244, complement)

Chromosome 13 - NC_000079.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Reciprocal stabilization of coagulation factor XIII-A and -B subunits is a determinant of plasma FXIII concentration.
Title: Reciprocal stabilization of coagulation factor XIII-A and -B subunits is a determinant of plasma FXIII concentration.
Mast cell-derived factor XIIIA contributes to sexual dimorphic defense against group B streptococcal infections.
Title: Mast cell-derived factor XIIIA contributes to sexual dimorphic defense against group B streptococcal infections.
Elimination of fibrin gamma-chain cross-linking by FXIIIa increases pulmonary embolism arising from murine inferior vena cava thrombi.
Title: Elimination of fibrin γ-chain cross-linking by FXIIIa increases pulmonary embolism arising from murine inferior vena cava thrombi.
Sustained depletion of FXIII-A by inducing acquired FXIII-B deficiency.
Title: Sustained depletion of FXIII-A by inducing acquired FXIII-B deficiency.
Assessment of expression and specific activities of transglutaminases TG1, TG2, and FXIII-A during osteoclastogenesis.
Title: Assessment of expression and specific activities of transglutaminases TG1, TG2, and FXIII-A during osteoclastogenesis.
Factor XIII-A and TG2 regulate resorption, adipogenesis and plasma fibronectin homeostasis in bone and bone marrow.
Title: Transglutaminases factor XIII-A and TG2 regulate resorption, adipogenesis and plasma fibronectin homeostasis in bone and bone marrow.
Suggest that resident macrophages maintain plasma FXIII-A and exclude the platelet lineage as a major contributor.
Title: Cre/lox Studies Identify Resident Macrophages as the Major Source of Circulating Coagulation Factor XIII-A.
These findings provide insight into assembly of the fibrinogen/FXIII-A2B2 complex in both physiologic and therapeutic situations.
Title: The interaction between fibrinogen and zymogen FXIII-A2B2 is mediated by fibrinogen residues γ390-396 and the FXIII-B subunits.
Mast cells have the ability to produce and degrade FXIIIA depending on their chymase expression profile: mast cells expressing chymase degrade FXIIIA, whereas mast cells that do not express chymase mainly produce FXIIIA
Title: Proteome analysis of mast cell releasates reveals a role for chymase in the regulation of coagulation factor XIIIA levels via proteolytic degradation.
A lack of factor XIII leads to prolonged clotting times, increased signs of inflammation, and elevated bacterial dissemination in streptococcal skin diseases.
Title: Local activation of coagulation factor XIII reduces systemic complications and improves the survival of mice after Streptococcus pyogenes M1 skin infection.

Submit: New GeneRIF Correction See all GeneRIFs (35)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (6) 1 citation
Endonuclease-mediated (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AI462306 (e-PCR)
- UniSTS:180518

D13Mit266 (e-PCR), detects polymorphism
- UniSTS:127083

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables acyltransferase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein-glutamine gamma-glutamyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein-glutamine gamma-glutamyltransferase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables protein-glutamine gamma-glutamyltransferase activity	ISO Inferred from Sequence Orthology more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within blood coagulation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in blood coagulation, fibrin clot formation	IBA Inferred from Biological aspect of Ancestor more info
involved_in blood coagulation, fibrin clot formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in blood coagulation, fibrin clot formation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within hemostasis	IEA Inferred from Electronic Annotation more info
involved_in peptide cross-linking	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within peptide cross-linking	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in peptide cross-linking	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in collagen-containing extracellular matrix	HDA more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: coagulation factor XIII A chain

Names: coagulation factor XIII, alpha subunit; coagulation factor XIIIa; protein-glutamine gamma-glutamyltransferase A chain; transglutaminase A chain

NP_001159863.1

EC 2.3.2.13

NP_083060.2

EC 2.3.2.13

XP_036014090.1

EC 2.3.2.13

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001166391.1 → NP_001159863.1 coagulation factor XIII A chain

See identical proteins and their annotated locations for NP_001159863.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1 and 2 encode the same protein.

Source sequence(s)

AK030914, AK049092, AV249730, BM239113

Consensus CDS

CCDS26456.1

UniProtKB/Swiss-Prot

Q3TNF9, Q8BH61, Q8BIP2

UniProtKB/TrEMBL

Q3V3W7

Related

ENSMUSP00000128316.2, ENSMUST00000164727.8

Conserved Domains (4) summary

smart00460
Location:309 → 400

TGc; Transglutaminase/protease-like homologues

COG1305
Location:280 → 408

YebA; Transglutaminase-like enzyme, putative cysteine protease [Posttranslational modification, protein turnover, chaperones]

pfam00868
Location:47 → 164

Transglut_N; Transglutaminase family

pfam00927
Location:519 → 623

Transglut_C; Transglutaminase family, C-terminal ig like domain
NM_028784.3 → NP_083060.2 coagulation factor XIII A chain

See identical proteins and their annotated locations for NP_083060.2

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.

Source sequence(s)

AK049092, AV249730, BM239113

Consensus CDS

CCDS26456.1

UniProtKB/Swiss-Prot

Q3TNF9, Q8BH61, Q8BIP2

UniProtKB/TrEMBL

Q3V3W7

Related

ENSMUSP00000048667.9, ENSMUST00000037491.11

Conserved Domains (4) summary

smart00460
Location:309 → 400

TGc; Transglutaminase/protease-like homologues

COG1305
Location:280 → 408

YebA; Transglutaminase-like enzyme, putative cysteine protease [Posttranslational modification, protein turnover, chaperones]

pfam00868
Location:47 → 164

Transglut_N; Transglutaminase family

pfam00927
Location:519 → 623

Transglut_C; Transglutaminase family, C-terminal ig like domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000079.7 Reference GRCm39 C57BL/6J

Range

37051150..37234220 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036158197.1 → XP_036014090.1 coagulation factor XIII A chain isoform X1

Conserved Domains (2) summary

smart00460
Location:67 → 158

TGc; Transglutaminase/protease-like homologues

pfam00927
Location:277 → 381

Transglut_C; Transglutaminase family, C-terminal ig like domain