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Sec14l1 SEC14-like lipid binding 1 [ Mus musculus (house mouse) ]

Gene ID: 74136, updated on 5-Mar-2024

Summary

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Official Symbol
Sec14l1provided by MGI
Official Full Name
SEC14-like lipid binding 1provided by MGI
Primary source
MGI:MGI:1921386
See related
Ensembl:ENSMUSG00000020823 AllianceGenome:MGI:1921386
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Naa-35; 1200017E04Rik; 2810012L19Rik
Summary
Predicted to enable RIG-I binding activity. Predicted to be involved in choline transport and negative regulation of RIG-I signaling pathway. Predicted to act upstream of or within innate immune response and negative regulation of signal transduction. Predicted to be located in cytosol and nucleoplasm. Predicted to colocalize with Golgi apparatus. Is expressed in cerebral cortex marginal layer and lung. Orthologous to human SEC14L1 (SEC14 like lipid binding 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in adrenal adult (RPKM 39.9), lung adult (RPKM 31.2) and 27 other tissues See more
Orthologs
human all
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Genomic context

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Location:
11 E2; 11 81.99 cM
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (117005994..117050094)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (117115168..117159268)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_31237 Neighboring gene STARR-positive B cell enhancer ABC_E5302 Neighboring gene microRNA 6516 Neighboring gene small nucleolar RNA host gene 20 Neighboring gene predicted gene 11730 Neighboring gene STARR-positive B cell enhancer ABC_E9848 Neighboring gene 60S ribosomal protein L12 pseudogene Neighboring gene STARR-seq mESC enhancer starr_31240 Neighboring gene septin 9 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:117127061-117127170 Neighboring gene predicted gene, 39478 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:117153788-117154073 Neighboring gene STARR-seq mESC enhancer starr_31245 Neighboring gene STARR-positive B cell enhancer ABC_E4019 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:117181442-117181643 Neighboring gene STARR-positive B cell enhancer ABC_E8473 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:117187354-117187555 Neighboring gene predicted gene, 34065

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The Sec14 homology domain regulates the cellular distribution and transforming activity of the Rho-specific guanine nucleotide exchange factor Dbs. Kostenko EV, et al. J Biol Chem, 2005 Jan 28. PMID 15531584
  2. A novel view of the transcriptome revealed from gene trapping in mouse embryonic stem cells. Roma G, et al. Genome Res, 2007 Jul. PMID 17540781, Free PMC Article
  3. Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2004 Jun 30. PMID 15368895
  4. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199
  5. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. the Sec14 domain regulates Dbs transformation through at least two distinct mechanisms, neither of which appears to directly influence the in vivo exchange activity of the protein
    Title: The Sec14 homology domain regulates the cellular distribution and transforming activity of the Rho-specific guanine nucleotide exchange factor Dbs.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RIG-I binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RIG-I binding ISO
Inferred from Sequence Orthology
more info
  
enables protein sequestering activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in choline transport ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within immune system process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within innate immune response IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of RIG-I signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of RIG-I signaling pathway ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within negative regulation of signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
colocalizes_with Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
SEC14-like protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001166506.2 → NP_001159978.1  SEC14-like protein 1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AK047396, AL627205, BB646963, BC086620
    Consensus CDS
    CCDS48989.1
    UniProtKB/Swiss-Prot
    A2A9B9, A8Y5H7, Q6A071, Q99J07, Q9DBQ0
    Related
    ENSMUSP00000087916.6, ENSMUST00000090433.6
    Conserved Domains (3) summary
    smart01100
    Location:256 → 301
    CRAL_TRIO_N; CRAL/TRIO, N-terminal domain
    pfam00650
    Location:326 → 490
    CRAL_TRIO; CRAL/TRIO domain
    pfam04707
    Location:17 → 173
    PRELI; PRELI-like family

  2. NM_001166507.2 → NP_001159979.1  SEC14-like protein 1 isoform 3

    See identical proteins and their annotated locations for NP_001159979.1

    Status: VALIDATED

    Source sequence(s)
    AK047396, AL627205, BB646963, BC086620
    Consensus CDS
    CCDS48988.1
    UniProtKB/Swiss-Prot
    A8Y5H7
    Related
    ENSMUSP00000099315.4, ENSMUST00000103026.10
    Conserved Domains (3) summary
    smart01100
    Location:256 → 301
    CRAL_TRIO_N; CRAL/TRIO, N-terminal domain
    pfam00650
    Location:326 → 490
    CRAL_TRIO; CRAL/TRIO domain
    pfam04707
    Location:17 → 173
    PRELI; PRELI-like family

  3. NM_001363165.1 → NP_001350094.1  SEC14-like protein 1 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AL627205
    Conserved Domains (3) summary
    smart01100
    Location:222 → 267
    CRAL_TRIO_N; CRAL/TRIO, N-terminal domain
    pfam00650
    Location:292 → 456
    CRAL_TRIO; CRAL/TRIO domain
    pfam04707
    Location:1 → 139
    PRELI; PRELI-like family

  4. NM_028777.4 → NP_083053.2  SEC14-like protein 1 isoform 1

    See identical proteins and their annotated locations for NP_083053.2

    Status: VALIDATED

    Source sequence(s)
    AK004818, AK047396, AL627205, BB646963, BC086620
    Consensus CDS
    CCDS25683.1
    UniProtKB/Swiss-Prot
    A8Y5H7
    Related
    ENSMUSP00000021177.9, ENSMUST00000021177.15
    Conserved Domains (3) summary
    smart01100
    Location:256 → 301
    CRAL_TRIO_N; CRAL/TRIO, N-terminal domain
    pfam00650
    Location:326 → 490
    CRAL_TRIO; CRAL/TRIO domain
    pfam04707
    Location:17 → 173
    PRELI; PRELI-like family

RNA

  1. NR_029459.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AK047396, AL627205, BB646963, CJ066501
    Related
    ENSMUST00000146585.2

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    117005994..117050094
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006534352.2 → XP_006534415.1  SEC14-like protein 1 isoform X1

    Conserved Domains (3) summary
    smart01100
    Location:222 → 267
    CRAL_TRIO_N; CRAL/TRIO, N-terminal domain
    pfam00650
    Location:292 → 456
    CRAL_TRIO; CRAL/TRIO domain
    pfam04707
    Location:1 → 139
    PRELI; PRELI-like family
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A8Y5H7.1 GenPept UniProtKB/Swiss-Prot:A8Y5H7

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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