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Armc8 armadillo repeat containing 8 [ Mus musculus (house mouse) ]

Gene ID: 74125, updated on 5-Mar-2024

Summary

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Official Symbol
Armc8provided by MGI
Official Full Name
armadillo repeat containing 8provided by MGI
Primary source
MGI:MGI:1921375
See related
Ensembl:ENSMUSG00000032468 AllianceGenome:MGI:1921375
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gid5; HSPC056; 1200015K23Rik
Summary
Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process. Predicted to be located in cytosol and nucleoplasm. Predicted to be part of GID complex and ubiquitin ligase complex. Orthologous to human ARMC8 (armadillo repeat containing 8). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E18 (RPKM 10.3), whole brain E14.5 (RPKM 9.2) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
9 E3.3; 9 51.74 cM
Exon count:
22
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (99360438..99451471, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (99478385..99568907, complement)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene muscle and microspikes RAS Neighboring gene predicted gene, 53543 Neighboring gene RIKEN cDNA 1600029I14 gene Neighboring gene STARR-seq mESC enhancer starr_25026 Neighboring gene NME/NM23 family member 9 Neighboring gene STARR-positive B cell enhancer ABC_E6796 Neighboring gene debranching RNA lariats 1 Neighboring gene alpha-1,4-N-acetylglucosaminyltransferase

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Proteasome-dependent degradation of alpha-catenin is regulated by interaction with ARMc8alpha. Suzuki T, et al. Biochem J, 2008 May 1. PMID 18215130
  2. Loss of the tumor suppressor BAP1 causes myeloid transformation. Dey A, et al. Science, 2012 Sep 21. PMID 22878500, Free PMC Article
  3. Ubiquitin ligase COP1 coordinates transcriptional programs that control cell type specification in the developing mouse brain. Newton K, et al. Proc Natl Acad Sci U S A, 2018 Oct 30. PMID 30322923, Free PMC Article
  4. The ATG5 interactome links clathrin-mediated vesicular trafficking with the autophagosome assembly machinery. Baines K, et al. Autophagy Rep, 2022. PMID 35449600, Free PMC Article
  5. A CRISPR-based screen for Hedgehog signaling provides insights into ciliary function and ciliopathies. Breslow DK, et al. Nat Genet, 2018 Mar. PMID 29459677, Free PMC Article

See all (26) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1)  1 citation
  • Endonuclease-mediated (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of GID complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
part_of ubiquitin ligase complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
armadillo repeat-containing protein 8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001166138.1 → NP_001159610.1  armadillo repeat-containing protein 8 isoform 2

    See identical proteins and their annotated locations for NP_001159610.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (2) has a shorter and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AK004793, AK078280, AK083094, BC038866
    Consensus CDS
    CCDS81059.1
    UniProtKB/Swiss-Prot
    Q9DBR3
    Related
    ENSMUSP00000139973.2, ENSMUST00000185524.7
    Conserved Domains (2) summary
    cd00020
    Location:57 → 172
    ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
    sd00043
    Location:57 → 90
    ARM; armadillo repeat [structural motif]

  2. NM_028768.3 → NP_083044.2  armadillo repeat-containing protein 8 isoform 1

    See identical proteins and their annotated locations for NP_083044.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC156497, AK004793
    Consensus CDS
    CCDS23434.1
    UniProtKB/Swiss-Prot
    Q8BGV2, Q8BUP3, Q9DBR3
    UniProtKB/TrEMBL
    G3X920
    Related
    ENSMUSP00000035043.6, ENSMUST00000035043.12
    Conserved Domains (3) summary
    cd00020
    Location:57 → 172
    ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
    sd00044
    Location:553 → 583
    HEAT; HEAT repeat [structural motif]
    sd00043
    Location:57 → 90
    ARM; armadillo repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    99360438..99451471 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036155355.1 → XP_036011248.1  armadillo repeat-containing protein 8 isoform X4

    UniProtKB/Swiss-Prot
    Q8BGV2, Q8BUP3, Q9DBR3
    Conserved Domains (4) summary
    COG5064
    Location:49 → 212
    SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
    COG5369
    Location:307 → 601
    COG5369; Uncharacterized conserved protein [Function unknown]
    sd00044
    Location:486 → 516
    HEAT; HEAT repeat [structural motif]
    sd00043
    Location:57 → 90
    ARM; armadillo repeat [structural motif]

  2. XM_006511515.5 → XP_006511578.1  armadillo repeat-containing protein 8 isoform X5

    UniProtKB/Swiss-Prot
    Q8BGV2, Q8BUP3, Q9DBR3
    Conserved Domains (3) summary
    COG5064
    Location:49 → 212
    SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
    COG5369
    Location:381 → 584
    COG5369; Uncharacterized conserved protein [Function unknown]
    sd00043
    Location:57 → 90
    ARM; armadillo repeat [structural motif]

  3. XM_006511513.5 → XP_006511576.1  armadillo repeat-containing protein 8 isoform X3

    UniProtKB/Swiss-Prot
    Q8BGV2, Q8BUP3, Q9DBR3
    Conserved Domains (3) summary
    COG5064
    Location:49 → 212
    SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
    COG5369
    Location:378 → 613
    COG5369; Uncharacterized conserved protein [Function unknown]
    sd00043
    Location:57 → 90
    ARM; armadillo repeat [structural motif]

  4. XM_006511511.5 → XP_006511574.1  armadillo repeat-containing protein 8 isoform X1

    UniProtKB/Swiss-Prot
    Q8BGV2, Q8BUP3, Q9DBR3
    Conserved Domains (3) summary
    COG5064
    Location:49 → 212
    SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
    COG5369
    Location:374 → 539
    COG5369; Uncharacterized conserved protein [Function unknown]
    sd00043
    Location:57 → 90
    ARM; armadillo repeat [structural motif]

  5. XM_006511512.4 → XP_006511575.1  armadillo repeat-containing protein 8 isoform X2

    UniProtKB/Swiss-Prot
    Q8BGV2, Q8BUP3, Q9DBR3
    Conserved Domains (4) summary
    COG5064
    Location:7 → 170
    SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
    COG5369
    Location:332 → 626
    COG5369; Uncharacterized conserved protein [Function unknown]
    sd00044
    Location:511 → 541
    HEAT; HEAT repeat [structural motif]
    sd00043
    Location:15 → 48
    ARM; armadillo repeat [structural motif]
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9DBR3.2 GenPept UniProtKB/Swiss-Prot:Q9DBR3

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