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Zfp263 zinc finger protein 263 [ Mus musculus (house mouse) ]

Gene ID: 74120, updated on 5-Mar-2024

Summary

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Official Symbol
Zfp263provided by MGI
Official Full Name
zinc finger protein 263provided by MGI
Primary source
MGI:MGI:1921370
See related
Ensembl:ENSMUSG00000022529 AllianceGenome:MGI:1921370
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
NT2; Znf263; mFPM315; 1200014J04Rik
Summary
Enables DNA binding activity. Acts upstream of or within negative regulation of transcription, DNA-templated. Located in nucleus. Is expressed in early conceptus and genitourinary system. Orthologous to human ZNF263 (zinc finger protein 263). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in bladder adult (RPKM 5.6), CNS E18 (RPKM 4.9) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Zfp263 in Genome Data Viewer
Location:
16 A1; 16 2.2 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (3561883..3568654)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (3744099..3750790)

Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene teratocarcinoma-derived growth factor, pseudogene 1 Neighboring gene predicted gene, 57641 Neighboring gene STARR-positive B cell enhancer ABC_E4152 Neighboring gene predicted gene, 36195 Neighboring gene STARR-seq mESC enhancer starr_39909 Neighboring gene predicted gene, 41409

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Isolation of a cDNA encoding a widely expressed novel zinc finger protein with the LeR and KRAB-A domains. Yokoyama M, et al. Biochim Biophys Acta, 1997 Jul 17. PMID 9256059
  2. Identification of SCAN dimerization domains in four gene families. Honer C, et al. Biochim Biophys Acta, 2001 Feb 16. PMID 11342224
  3. Sexual fate of murine external genitalia development: Conserved transcriptional competency for male-biased genes in both sexes. Kajioka D, et al. Proc Natl Acad Sci U S A, 2021 Jun 8. PMID 34074765, Free PMC Article
  4. Regulation of SPRY3 by X chromosome and PAR2-linked promoters in an autism susceptibility region. Ning Z, et al. Hum Mol Genet, 2015 Sep 15. PMID 26089202
  5. The mouse mahoganoid coat color mutation disrupts a novel C3HC4 RING domain protein. Phan LK, et al. J Clin Invest, 2002 Nov. PMID 12438443, Free PMC Article

See all (26) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IDA
Inferred from Direct Assay
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA-binding transcription repressor activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables sequence-specific double-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables transcription cis-regulatory region binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within negative regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
  
involved_in negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
zinc finger protein 263
Names
kruppel-associated box-zinc finger protein NT2
zinc finger protein FPM315
zinc finger protein with KRAB and SCAN domains 12

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_148924.3 → NP_683726.2  zinc finger protein 263

    See identical proteins and their annotated locations for NP_683726.2

    Status: VALIDATED

    Source sequence(s)
    AK004765, BY507217, BY718780
    Consensus CDS
    CCDS27909.1
    UniProtKB/Swiss-Prot
    E9PXW0, Q7TMI6, Q8CF60, Q8K439
    Related
    ENSMUSP00000023176.5, ENSMUST00000023176.5
    Conserved Domains (6) summary
    smart00431
    Location:41 → 151
    SCAN; leucine rich region
    cd07765
    Location:219 → 253
    KRAB_A-box; KRAB (Kruppel-associated box) domain -A box
    COG5048
    Location:415 → 646
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:436 → 456
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:380 → 400
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:645 → 667
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000082.7 Reference GRCm39 C57BL/6J

    Range
    3561883..3568654
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006522653.4 → XP_006522716.1  zinc finger protein 263 isoform X1

    Related
    ENSMUST00000159425.8
    Conserved Domains (4) summary
    COG5048
    Location:298 → 484
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:274 → 294
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:483 → 505
    zf-H2C2_2; Zinc-finger double domain
    cl02581
    Location:58 → 116
    KRAB_A-box; KRAB (Kruppel-associated box) domain -A box
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8CF60.1 GenPept UniProtKB/Swiss-Prot:Q8CF60

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