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Pi16 peptidase inhibitor 16 [ Mus musculus (house mouse) ]

Gene ID: 74116, updated on 7-Apr-2024

Summary

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Official Symbol
Pi16provided by MGI
Official Full Name
peptidase inhibitor 16provided by MGI
Primary source
MGI:MGI:1921366
See related
Ensembl:ENSMUSG00000024011 AllianceGenome:MGI:1921366
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Cripi; PI-16; 1200009H11Rik
Summary
Predicted to enable peptidase inhibitor activity. Acts upstream of or within negative regulation of cell growth involved in cardiac muscle cell development. Located in extracellular space. Is expressed in cranial ganglion; dorsal root ganglion; medulla oblongata basal plate mantle layer; and neural retina. Orthologous to human PI16 (peptidase inhibitor 16). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in bladder adult (RPKM 160.4), mammary gland adult (RPKM 72.5) and 6 other tissues See more
Orthologs
human all
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Genomic context

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Location:
17 A3.3; 17 15.22 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (29537770..29547876)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (29318796..29328903)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene cDNA sequence BC004004 Neighboring gene predicted gene, 53222 Neighboring gene predicted pseudogene 10045 Neighboring gene predicted gene, 46603 Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:29469332-29469441 Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:29475389-29475661 Neighboring gene mitochondrial carrier 1 Neighboring gene STARR-positive B cell enhancer ABC_E4202 Neighboring gene STARR-positive B cell enhancer ABC_E5586 Neighboring gene STARR-positive B cell enhancer ABC_E7508 Neighboring gene FYVE, RhoGEF and PH domain containing 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The fibroblast-derived protein PI16 controls neuropathic pain. Singhmar P, et al. Proc Natl Acad Sci U S A, 2020 Mar 10. PMID 32079726, Free PMC Article
  2. Peptidase inhibitor 16 is a membrane-tethered regulator of chemerin processing in the myocardium. Regn M, et al. J Mol Cell Cardiol, 2016 Oct. PMID 27539859
  3. A secretion trap screen in yeast identifies protease inhibitor 16 as a novel antihypertrophic protein secreted from the heart. Frost RJ, et al. Circulation, 2007 Oct 16. PMID 17909105
  4. Overexpression of peptidase inhibitor 16 attenuates angiotensin II-induced cardiac fibrosis via regulating HDAC1 of cardiac fibroblasts. Deng M, et al. J Cell Mol Med, 2020 May. PMID 32227584, Free PMC Article
  5. Defining the lineage of thermogenic perivascular adipose tissue. Angueira AR, et al. Nat Metab, 2021 Apr. PMID 33846639, Free PMC Article

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Regulatory role of PI16 in autoimmune arthritis and intestinal inflammation: implications for Treg cell differentiation and function.
    Title: Regulatory role of PI16 in autoimmune arthritis and intestinal inflammation: implications for Treg cell differentiation and function.
  2. Peptidase inhibitor 16 promotes inflammatory arthritis by suppressing Foxp3 expression via regulating K48-linked ubiquitin degradation Bmi-1 in regulatory T cells.
    Title: Peptidase inhibitor 16 promotes inflammatory arthritis by suppressing Foxp3 expression via regulating K48-linked ubiquitin degradation Bmi-1 in regulatory T cells.
  3. Overexpression of peptidase inhibitor 16 attenuates angiotensin II-induced cardiac fibrosis via regulating HDAC1 of cardiac fibroblasts.
    Title: Overexpression of peptidase inhibitor 16 attenuates angiotensin II-induced cardiac fibrosis via regulating HDAC1 of cardiac fibroblasts.
  4. these findings support a model in which PI16 promotes neuropathic pain by mediating a cross-talk between fibroblasts and the endothelial barrier leading to barrier opening, cellular influx, and increased pain
    Title: The fibroblast-derived protein PI16 controls neuropathic pain.
  5. our data indicate that PI16 suppresses chemerin activation in the myocardium and suggest that this circuit may be part of the cardiac stress response.
    Title: Peptidase inhibitor 16 is a membrane-tethered regulator of chemerin processing in the myocardium.
  6. PI16, a novel protein secreted from the heart, is strongly upregulated early in heart failure and inhibits growth of cardiomyocytes both in vitro and in vivo
    Title: A secretion trap screen in yeast identifies protease inhibitor 16 as a novel antihypertrophic protein secreted from the heart.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (1)  1 citation
  • Endonuclease-mediated (4) 

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables peptidase inhibitor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within negative regulation of cell growth involved in cardiac muscle cell development IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within negative regulation of cell growth involved in cardiac muscle cell development ISO
Inferred from Sequence Orthology
more info
 PubMed 
acts_upstream_of_or_within negative regulation of peptidase activity IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extracellular space IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
peptidase inhibitor 16
Names
cysteine-rich protease inhibitor
protease inhibitor 16

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_023734.3 → NP_076223.3  peptidase inhibitor 16 precursor

    Status: VALIDATED

    Source sequence(s)
    AB046537, AI587910, AK157854
    Consensus CDS
    CCDS28595.2
    UniProtKB/Swiss-Prot
    Q148Q6, Q8CHU4, Q9ET66, Q9JJ56
    Related
    ENSMUSP00000110349.3, ENSMUST00000114701.10
    Conserved Domains (1) summary
    cd05559
    Location:35 → 168
    SCP_HrTT-1; SCP_HrTT-1: SCP-like extracellular protein domain in HrTT-1, a tail-tip epidermis marker in ascidians. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    29537770..29547876
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006525014.2 → XP_006525077.1  peptidase inhibitor 16 isoform X1

    UniProtKB/TrEMBL
    D3Z6T6
    Related
    ENSMUSP00000116183.3, ENSMUST00000155348.3
    Conserved Domains (1) summary
    cd05559
    Location:35 → 168
    CAP_PI16_HrTT-1; CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain of peptidase inhibitor 16 and HrTT-1 protein
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9ET66.2 GenPept UniProtKB/Swiss-Prot:Q9ET66

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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