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Crot carnitine O-octanoyltransferase [ Mus musculus (house mouse) ]

Gene ID: 74114, updated on 3-Apr-2024

Summary

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Official Symbol
Crotprovided by MGI
Official Full Name
carnitine O-octanoyltransferaseprovided by MGI
Primary source
MGI:MGI:1921364
See related
Ensembl:ENSMUSG00000003623 AllianceGenome:MGI:1921364
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
1200003H03Rik
Summary
Enables carnitine O-octanoyltransferase activity. Involved in carnitine metabolic process; coenzyme A metabolic process; and fatty acid metabolic process. Acts upstream of or within fatty acid transport. Located in peroxisome. Is expressed in several structures, including brain; ganglia; gut; liver; and spleen. Orthologous to human CROT (carnitine O-octanoyltransferase). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in liver adult (RPKM 39.3), liver E18 (RPKM 15.1) and 23 other tissues See more
Orthologs
human all
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Genomic context

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Location:
5 A1; 5 3.5 cM
Exon count:
20
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (9016033..9047926, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (8966033..8997146, complement)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene ATP-binding cassette, sub-family B member 4 Neighboring gene STARR-seq mESC enhancer starr_12399 Neighboring gene calponin 3, acidic pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E6299 Neighboring gene predicted gene, 31388 Neighboring gene STARR-seq mESC enhancer starr_12400 Neighboring gene coiled-coil domain-containing protein 72 pseudogene Neighboring gene STARR-positive B cell enhancer mm9_chr5:8997064-8997365 Neighboring gene STARR-seq mESC enhancer starr_12401 Neighboring gene STARR-seq mESC enhancer starr_12402 Neighboring gene STARR-seq mESC enhancer starr_12403 Neighboring gene predicted gene, 40264 Neighboring gene STARR-seq mESC enhancer starr_12404 Neighboring gene STARR-seq mESC enhancer starr_12405 Neighboring gene STARR-seq mESC enhancer starr_12406 Neighboring gene transmembrane protein 243, mitochondrial Neighboring gene cyclin D binding myb like transcription factor 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The Regulators of Peroxisomal Acyl-Carnitine Shuttle CROT and CRAT Promote Metastasis in Melanoma. Lasheras-Otero I, et al. J Invest Dermatol, 2023 Feb. PMID 36058299
  2. Crystal structure of mouse carnitine octanoyltransferase and molecular determinants of substrate selectivity. Jogl G, et al. J Biol Chem, 2005 Jan 7. PMID 15492013
  3. Localization of an exonic splicing enhancer responsible for mammalian natural trans-splicing. Caudevilla C, et al. Nucleic Acids Res, 2001 Jul 15. PMID 11452036, Free PMC Article
  4. Properties of purified carnitine acyltransferases of mouse liver peroxisomes. Farrell SO, et al. J Biol Chem, 1984 Nov 10. PMID 6436243
  5. CROT (Carnitine O-Octanoyltransferase) Is a Novel Contributing Factor in Vascular Calcification via Promoting Fatty Acid Metabolism and Mitochondrial Dysfunction. Okui T, et al. Arterioscler Thromb Vasc Biol, 2021 Feb. PMID 33356393, Free PMC Article

See all (25) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The Regulators of Peroxisomal Acyl-Carnitine Shuttle CROT and CRAT Promote Metastasis in Melanoma.
    Title: The Regulators of Peroxisomal Acyl-Carnitine Shuttle CROT and CRAT Promote Metastasis in Melanoma.
  2. CROT (Carnitine O-Octanoyltransferase) Is a Novel Contributing Factor in Vascular Calcification via Promoting Fatty Acid Metabolism and Mitochondrial Dysfunction.
    Title: CROT (Carnitine O-Octanoyltransferase) Is a Novel Contributing Factor in Vascular Calcification via Promoting Fatty Acid Metabolism and Mitochondrial Dysfunction.
  3. the crystal structures of carnitine octanoyltransferase alone and in complex with the substrate octanoylcarnitine
    Title: Crystal structure of mouse carnitine octanoyltransferase and molecular determinants of substrate selectivity.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables acyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables carnitine O-octanoyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables carnitine O-octanoyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables carnitine O-octanoyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in carnitine metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in coenzyme A metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in fatty acid beta-oxidation ISO
Inferred from Sequence Orthology
more info
  
involved_in fatty acid metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in fatty acid metabolic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within fatty acid transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in generation of precursor metabolites and energy ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within lipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in medium-chain fatty acid metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in response to xenobiotic stimulus ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrion HDA PubMed 
is_active_in peroxisome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in peroxisome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in peroxisome ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
peroxisomal carnitine O-octanoyltransferase
Names
COT
NP_001404759.1
NP_001404760.1
NP_001404761.1
NP_001404762.1
NP_076222.1
XP_006503673.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001417830.1 → NP_001404759.1  peroxisomal carnitine O-octanoyltransferase isoform a

    Status: VALIDATED

    Source sequence(s)
    AC107763
    UniProtKB/Swiss-Prot
    Q921I4, Q9DC50

  2. NM_001417831.1 → NP_001404760.1  peroxisomal carnitine O-octanoyltransferase isoform a

    Status: VALIDATED

    Source sequence(s)
    AC107763
    UniProtKB/Swiss-Prot
    Q921I4, Q9DC50

  3. NM_001417832.1 → NP_001404761.1  peroxisomal carnitine O-octanoyltransferase isoform a

    Status: VALIDATED

    Source sequence(s)
    AC107763
    UniProtKB/Swiss-Prot
    Q921I4, Q9DC50

  4. NM_001417833.1 → NP_001404762.1  peroxisomal carnitine O-octanoyltransferase isoform b

    Status: VALIDATED

    Source sequence(s)
    AC107763

  5. NM_023733.3 → NP_076222.1  peroxisomal carnitine O-octanoyltransferase isoform a

    See identical proteins and their annotated locations for NP_076222.1

    Status: VALIDATED

    Source sequence(s)
    AK004567
    Consensus CDS
    CCDS19087.1
    UniProtKB/Swiss-Prot
    Q921I4, Q9DC50
    Related
    ENSMUSP00000003720.5, ENSMUST00000003720.5
    Conserved Domains (1) summary
    pfam00755
    Location:20 → 603
    Carn_acyltransf; Choline/Carnitine o-acyltransferase

RNA

  1. NR_184637.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC107763

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    9016033..9047926 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006503610.4 → XP_006503673.1  peroxisomal carnitine O-octanoyltransferase isoform X2

    Conserved Domains (1) summary
    pfam00755
    Location:152 → 531
    Carn_acyltransf; Choline/Carnitine o-acyltransferase
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9DC50.1 GenPept UniProtKB/Swiss-Prot:Q9DC50

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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