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Dcaf6 DDB1 and CUL4 associated factor 6 [ Mus musculus (house mouse) ]

Gene ID: 74106, updated on 8-May-2024

Summary

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Official Symbol
Dcaf6provided by MGI
Official Full Name
DDB1 and CUL4 associated factor 6provided by MGI
Primary source
MGI:MGI:1921356
See related
Ensembl:ENSMUSG00000026571 AllianceGenome:MGI:1921356
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Iqwd1; PC326; 1200006M05Rik
Summary
Predicted to enable nuclear receptor coactivator activity. Predicted to be involved in positive regulation of transcription by RNA polymerase II. Predicted to be located in cytosol; focal adhesion; and nucleoplasm. Predicted to be part of Cul4-RING E3 ubiquitin ligase complex. Predicted to be active in cytoplasm. Orthologous to human DCAF6 (DDB1 and CUL4 associated factor 6). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis adult (RPKM 41.3), cortex adult (RPKM 13.4) and 27 other tissues See more
Orthologs
human all
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Genomic context

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Location:
1 H2.2- H2.3; 1 72.67 cM
Exon count:
25
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (165157069..165288475, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (165329500..165460906, complement)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene SFT2 domain containing 2 Neighboring gene STARR-seq mESC enhancer starr_02896 Neighboring gene TIP41, TOR signalling pathway regulator-like (S. cerevisiae) Neighboring gene STARR-seq mESC enhancer starr_02898 Neighboring gene G protein-coupled receptor 161 Neighboring gene STARR-seq mESC enhancer starr_02900 Neighboring gene STARR-positive B cell enhancer ABC_E2016 Neighboring gene STARR-positive B cell enhancer ABC_E119 Neighboring gene predicted gene, 24637 Neighboring gene mitochondrial pyruvate carrier 2 Neighboring gene adenylate cyclase 10 Neighboring gene peptidylprolyl isomerase A pseudogene 1_1625.1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Muscle-restricted nuclear receptor interaction protein knockout causes motor neuron degeneration through down-regulation of myogenin at the neuromuscular junction. Chen HH, et al. J Cachexia Sarcopenia Muscle, 2018 Aug. PMID 29608040, Free PMC Article
  2. Deficiency of nuclear receptor interaction protein leads to cardiomyopathy by disrupting sarcomere structure and mitochondrial respiration. Yang KC, et al. J Mol Cell Cardiol, 2019 Dec. PMID 31629737
  3. NRIP, a novel nuclear receptor interaction protein, enhances the transcriptional activity of nuclear receptors. Tsai TC, et al. J Biol Chem, 2005 May 20. PMID 15784617
  4. Autoantibody of NRIP, a novel AChR-interacting protein, plays a detrimental role in myasthenia gravis. Tsai LK, et al. J Cachexia Sarcopenia Muscle, 2021 Jun. PMID 33773096, Free PMC Article
  5. NRIP is newly identified as a Z-disc protein, activating calmodulin signaling for skeletal muscle contraction and regeneration. Chen HH, et al. J Cell Sci, 2015 Nov 15. PMID 26430214

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Autoantibody of NRIP, a novel AChR-interacting protein, plays a detrimental role in myasthenia gravis.
    Title: Autoantibody of NRIP, a novel AChR-interacting protein, plays a detrimental role in myasthenia gravis.
  2. we demonstrated that deprivation of NRIP decreases myogenin expression at NMJ, possibly leading to abnormal NMJ formation, denervation of acetylcholine receptor, and subsequent loss of spinal motor neuron.
    Title: Muscle-restricted nuclear receptor interaction protein knockout causes motor neuron degeneration through down-regulation of myogenin at the neuromuscular junction.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2)  1 citation
  • Endonuclease-mediated (3) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables nuclear receptor coactivator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables nuclear receptor coactivator activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of Cul4-RING E3 ubiquitin ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of Cul4-RING E3 ubiquitin ligase complex ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in focal adhesion ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
DDB1- and CUL4-associated factor 6
Names
IQ motif and WD repeat-containing protein 1
IQ motif and WD repeats 1
NRIP
nuclear receptor interaction protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_028759.1 → NP_083035.1  DDB1- and CUL4-associated factor 6

    See identical proteins and their annotated locations for NP_083035.1

    Status: VALIDATED

    Source sequence(s)
    AC116374, AC162789
    Consensus CDS
    CCDS48424.1
    UniProtKB/Swiss-Prot
    Q8BK50, Q9DC22
    Related
    ENSMUSP00000027856.8, ENSMUST00000027856.13
    Conserved Domains (3) summary
    COG2319
    Location:42 → 281
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:55 → 92
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:43 → 292
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    165157069..165288475 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030243204.1 → XP_030099064.1  DDB1- and CUL4-associated factor 6 isoform X7

    Conserved Domains (2) summary
    sd00039
    Location:48 → 99
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:5 → 145
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  2. XM_036153945.1 → XP_036009838.1  DDB1- and CUL4-associated factor 6 isoform X8

    Conserved Domains (1) summary
    cl29593
    Location:599 → 658
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  3. XM_036153915.1 → XP_036009808.1  DDB1- and CUL4-associated factor 6 isoform X1

    Conserved Domains (2) summary
    sd00039
    Location:55 → 92
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:43 → 292
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  4. XM_036153926.1 → XP_036009819.1  DDB1- and CUL4-associated factor 6 isoform X3

    Conserved Domains (2) summary
    sd00039
    Location:55 → 92
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:43 → 292
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  5. XM_036153932.1 → XP_036009825.1  DDB1- and CUL4-associated factor 6 isoform X5

    Conserved Domains (2) summary
    sd00039
    Location:55 → 92
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:43 → 292
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  6. XM_036153933.1 → XP_036009826.1  DDB1- and CUL4-associated factor 6 isoform X6

    Conserved Domains (2) summary
    sd00039
    Location:48 → 99
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:5 → 145
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  7. XM_036153936.1 → XP_036009829.1  DDB1- and CUL4-associated factor 6 isoform X6

    Conserved Domains (2) summary
    sd00039
    Location:48 → 99
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:5 → 145
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  8. XM_006497004.3 → XP_006497067.1  DDB1- and CUL4-associated factor 6 isoform X2

    Conserved Domains (2) summary
    sd00039
    Location:55 → 92
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:43 → 292
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  9. XM_006497005.3 → XP_006497068.1  DDB1- and CUL4-associated factor 6 isoform X4

    Conserved Domains (2) summary
    sd00039
    Location:55 → 92
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:43 → 292
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  10. XM_006497008.3 → XP_006497071.1  DDB1- and CUL4-associated factor 6 isoform X9

    Conserved Domains (2) summary
    sd00039
    Location:55 → 92
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:43 → 292
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  11. XM_036153948.1 → XP_036009841.1  DDB1- and CUL4-associated factor 6 isoform X9

    Conserved Domains (2) summary
    sd00039
    Location:55 → 92
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:43 → 292
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

RNA

  1. XR_004934804.1 RNA Sequence

  2. XR_004934805.1 RNA Sequence

  3. XR_373618.3 RNA Sequence

  4. XR_004934806.1 RNA Sequence

  5. XR_001778389.3 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9DC22.1 GenPept UniProtKB/Swiss-Prot:Q9DC22

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