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Czib CXXC motif containing zinc binding protein [ Mus musculus (house mouse) ]

Gene ID: 74098, updated on 5-Mar-2024

Summary

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Official Symbol
Czibprovided by MGI
Official Full Name
CXXC motif containing zinc binding proteinprovided by MGI
Primary source
MGI:MGI:1921348
See related
Ensembl:ENSMUSG00000028608 AllianceGenome:MGI:1921348
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
0610037L13Rik; 1110008H16Rik
Summary
Predicted to enable zinc ion binding activity. Orthologous to human CZIB (CXXC motif containing zinc binding protein). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in bladder adult (RPKM 22.6), limb E14.5 (RPKM 18.0) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
4 C7; 4 50.18 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (107746982..107755000)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (107889785..107897803)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene low density lipoprotein receptor-related protein 8, apolipoprotein e receptor, opposite strand 2 Neighboring gene low density lipoprotein receptor-related protein 8, apolipoprotein e receptor Neighboring gene STARR-positive B cell enhancer ABC_E4643 Neighboring gene STARR-positive B cell enhancer ABC_E1649 Neighboring gene mago homolog, exon junction complex core component Neighboring gene carnitine palmitoyltransferase 2 Neighboring gene predicted gene, 40221

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. BioID screening of biotinylation sites using the avidin-like protein Tamavidin 2-REV identifies global interactors of stimulator of interferon genes (STING). Motani K, et al. J Biol Chem, 2020 Aug 7. PMID 32554809, Free PMC Article
  2. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article
  3. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
  4. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548
  5. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables molecular_function ND
No biological Data available
more info
  
enables zinc ion binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables zinc ion binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  

General protein information

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Preferred Names
CXXC motif containing zinc binding protein
Names
UPF0587 protein C1orf123 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001347160.1 → NP_001334089.1  CXXC motif containing zinc binding protein isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (2) has a shorter and distinct N-terminus compared to isoform 1.
    Source sequence(s)
    AL611936
    Consensus CDS
    CCDS84769.1
    UniProtKB/Swiss-Prot
    A2A8E3, A2A8E5, Q8BHG2, Q8C7D6, Q9D1H2, Q9DCH5
    UniProtKB/TrEMBL
    A2A8E2
    Related
    ENSMUSP00000114234.2, ENSMUST00000135454.8
    Conserved Domains (1) summary
    pfam05907
    Location:6 → 157
    DUF866; Eukaryotic protein of unknown function (DUF866)

  2. NM_028754.2 → NP_083030.1  CXXC motif containing zinc binding protein isoform 1

    See identical proteins and their annotated locations for NP_083030.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AL611936
    Consensus CDS
    CCDS18442.1
    UniProtKB/Swiss-Prot
    Q8BHG2
    Related
    ENSMUSP00000119565.2, ENSMUST00000125107.8
    Conserved Domains (1) summary
    pfam05907
    Location:42 → 193
    DUF866; Eukaryotic protein of unknown function (DUF866)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    107746982..107755000
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030253839.1 → XP_030109699.1  CXXC motif containing zinc binding protein isoform X3

    UniProtKB/TrEMBL
    B7ZC72
    Related
    ENSMUSP00000102338.4, ENSMUST00000106727.10
    Conserved Domains (1) summary
    pfam05907
    Location:8 → 136
    DUF866; Eukaryotic protein of unknown function (DUF866)

  2. XM_036164493.1 → XP_036020386.1  CXXC motif containing zinc binding protein isoform X5

    Conserved Domains (1) summary
    pfam05907
    Location:3 → 108
    DUF866; Eukaryotic protein of unknown function (DUF866)

  3. XM_006503440.4 → XP_006503503.1  CXXC motif containing zinc binding protein isoform X4

    Conserved Domains (1) summary
    pfam05907
    Location:4 → 128
    DUF866; Eukaryotic protein of unknown function (DUF866)

  4. XM_006503437.4 → XP_006503500.1  CXXC motif containing zinc binding protein isoform X1

    UniProtKB/TrEMBL
    A2A8E2
    Conserved Domains (1) summary
    pfam05907
    Location:9 → 157
    DUF866; Eukaryotic protein of unknown function (DUF866)

  5. XM_006503439.3 → XP_006503502.1  CXXC motif containing zinc binding protein isoform X2

    UniProtKB/TrEMBL
    B7ZC72
    Conserved Domains (1) summary
    pfam05907
    Location:9 → 137
    DUF866; Eukaryotic protein of unknown function (DUF866)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BHG2.1 GenPept UniProtKB/Swiss-Prot:Q8BHG2

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