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Paqr5 progestin and adipoQ receptor family member V [ Mus musculus (house mouse) ]

Gene ID: 74090, updated on 5-Mar-2024

Summary

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Official Symbol
Paqr5provided by MGI
Official Full Name
progestin and adipoQ receptor family member Vprovided by MGI
Primary source
MGI:MGI:1921340
See related
Ensembl:ENSMUSG00000032278 AllianceGenome:MGI:1921340
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
mPRg; 0610010I15Rik
Summary
Predicted to enable signaling receptor activity. Predicted to act upstream of or within oogenesis. Predicted to be located in plasma membrane. Predicted to be integral component of membrane. Is expressed in late tubule. Orthologous to human PAQR5 (progestin and adipoQ receptor family member 5). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in testis adult (RPKM 97.4), kidney adult (RPKM 47.4) and 3 other tissues See more
Orthologs
human all
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Genomic context

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See Paqr5 in Genome Data Viewer
Location:
9 B; 9 33.52 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (61861020..61934085, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (61953738..62026852, complement)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E6748 Neighboring gene ribosomal protein lateral stalk subunit P1 Neighboring gene kinesin family member 23 Neighboring gene STARR-positive B cell enhancer mm9_chr9:61794519-61794820 Neighboring gene STARR-positive B cell enhancer mm9_chr9:61795876-61796177 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:61808677-61808878 Neighboring gene STARR-positive B cell enhancer ABC_E5075 Neighboring gene predicted gene, 35152 Neighboring gene glucuronyl C5-epimerase Neighboring gene STARR-positive B cell enhancer ABC_E570 Neighboring gene STARR-seq mESC enhancer starr_24364 Neighboring gene microRNA 5133 Neighboring gene predicted gene, 39351

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Membrane progestin receptors alpha and gamma in renal epithelium. Lemale J, et al. Biochim Biophys Acta, 2008 Dec. PMID 18722485
  2. Activation of enteroendocrine membrane progesterone receptors promotes incretin secretion and improves glucose tolerance in mice. Flock GB, et al. Diabetes, 2013 Jan. PMID 22933106, Free PMC Article
  3. PAQR proteins: a novel membrane receptor family defined by an ancient 7-transmembrane pass motif. Tang YT, et al. J Mol Evol, 2005 Sep. PMID 16044242
  4. GUDMAP: the genitourinary developmental molecular anatomy project. McMahon AP, et al. J Am Soc Nephrol, 2008 Apr. PMID 18287559
  5. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 

General gene information

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Markers

Homology

Clone Names

  • MGC118370

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables lipid binding IEA
Inferred from Electronic Annotation
more info
  
enables signaling receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables steroid binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within cell differentiation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within multicellular organism development IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within oogenesis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
membrane progestin receptor gamma
Names
mPR gamma
membrane progesterone P4 receptor gamma
membrane progesterone receptor gamma
progesterone and adipoQ receptor family member 5
progestin and adipoQ receptor family member 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001417861.1 → NP_001404790.1  membrane progestin receptor gamma isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC151969
    UniProtKB/TrEMBL
    Q497J6
    Related
    ENSMUSP00000109623.2, ENSMUST00000113990.2

  2. NM_001417862.1 → NP_001404791.1  membrane progestin receptor gamma isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC151969

  3. NM_001417863.1 → NP_001404792.1  membrane progestin receptor gamma isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC151969

  4. NM_028748.3 → NP_083024.1  membrane progestin receptor gamma isoform 1

    See identical proteins and their annotated locations for NP_083024.1

    Status: VALIDATED

    Source sequence(s)
    AC151969
    Consensus CDS
    CCDS23261.1
    UniProtKB/Swiss-Prot
    Q7TPQ5, Q8C6Z8, Q9DCU0
    Related
    ENSMUSP00000034817.5, ENSMUST00000034817.11
    Conserved Domains (1) summary
    pfam03006
    Location:43 → 269
    HlyIII; Haemolysin-III related

RNA

  1. NR_184645.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC151969

  2. NR_184646.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC151969

  3. NR_184647.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC151969
    Related
    ENSMUST00000135050.2

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    61861020..61934085 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9DCU0.1 GenPept UniProtKB/Swiss-Prot:Q9DCU0

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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