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Cep350 centrosomal protein 350 [ Mus musculus (house mouse) ]

Gene ID: 74081, updated on 5-Mar-2024

Summary

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Official Symbol
Cep350provided by MGI
Official Full Name
centrosomal protein 350provided by MGI
Primary source
MGI:MGI:1921331
See related
Ensembl:ENSMUSG00000033671 AllianceGenome:MGI:1921331
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
4933409L06Rik; 6430546F08Rik
Summary
Predicted to enable microtubule binding activity. Acts upstream of or within non-motile cilium assembly and protein localization to centrosome. Predicted to be located in centriole and centrosome. Is expressed in brain; lung; and testis. Orthologous to human CEP350 (centrosomal protein 350). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis adult (RPKM 5.6), CNS E18 (RPKM 3.6) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
1 G3; 1 67.64 cM
Exon count:
39
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (155720710..155848976, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (155844964..155973270, complement)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_02727 Neighboring gene LIM homeobox protein 4 Neighboring gene quiescin Q6 sulfhydryl oxidase 1 Neighboring gene STARR-positive B cell enhancer mm9_chr1:157659814-157660115 Neighboring gene predicted gene, 36934 Neighboring gene predicted gene, 51652 Neighboring gene STARR-positive B cell enhancer ABC_E9186 Neighboring gene predicted gene, 23744 Neighboring gene predicted gene, 53631 Neighboring gene torsin A interacting protein 1 Neighboring gene predicted gene, 51653

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. CFAP157 is a murine downstream effector of FOXJ1 that is specifically required for flagellum morphogenesis and sperm motility. Weidemann M, et al. Development, 2016 Dec 15. PMID 27965440
  2. EB1 is required for primary cilia assembly in fibroblasts. Schrøder JM, et al. Curr Biol, 2007 Jul 3. PMID 17600711
  3. Ptbp2 represses adult-specific splicing to regulate the generation of neuronal precursors in the embryonic brain. Licatalosi DD, et al. Genes Dev, 2012 Jul 15. PMID 22802532, Free PMC Article
  4. Functional genomic landscape of cancer-intrinsic evasion of killing by T cells. Lawson KA, et al. Nature, 2020 Oct. PMID 32968282, Free PMC Article
  5. Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2004 Jun 30. PMID 15368895

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC107324

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables microtubule binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in microtubule anchoring IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within non-motile cilium assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within protein localization to centrosome IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cell projection IEA
Inferred from Electronic Annotation
more info
  
located_in centriole ISO
Inferred from Sequence Orthology
more info
  
located_in centrosome ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
centrosome-associated protein 350

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001039184.2 → NP_001034273.1  centrosome-associated protein 350

    Status: VALIDATED

    Source sequence(s)
    AC120391, AC121314
    Consensus CDS
    CCDS48400.1
    UniProtKB/Swiss-Prot
    A0A1D5RMJ4, D3YTP2, E9Q309, Q6A062, Q8BXM7
    Related
    ENSMUSP00000120085.2, ENSMUST00000138762.8
    Conserved Domains (3) summary
    pfam01302
    Location:2486 → 2550
    CAP_GLY; CAP-Gly domain
    cl25632
    Location:1317 → 1439
    type_I_hlyD; type I secretion membrane fusion protein, HlyD family
    cl26511
    Location:1563 → 2290
    Neuromodulin_N; Gap junction protein N-terminal region

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    155720710..155848976 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006529903.5 → XP_006529966.1  centrosome-associated protein 350 isoform X3

    Conserved Domains (5) summary
    PTZ00121
    Location:1335 → 1813
    PTZ00121; MAEBL; Provisional
    COG5022
    Location:2094 → 2374
    COG5022; Myosin heavy chain [General function prediction only]
    COG5244
    Location:2530 → 2807
    NIP100; Dynactin complex subunit involved in mitotic spindle partitioning in anaphase B [Cell cycle control, cell division, chromosome partitioning]
    PTZ00108
    Location:1889 → 2150
    PTZ00108; DNA topoisomerase 2-like protein; Provisional
    pfam01302
    Location:2530 → 2594
    CAP_GLY; CAP-Gly domain

  2. XM_006529907.5 → XP_006529970.1  centrosome-associated protein 350 isoform X9

    Conserved Domains (4) summary
    TIGR01843
    Location:1318 → 1440
    type_I_hlyD; type I secretion membrane fusion protein, HlyD family
    PTZ00121
    Location:1564 → 2291
    PTZ00121; MAEBL; Provisional
    COG5244
    Location:2487 → 2764
    NIP100; Dynactin complex subunit involved in mitotic spindle partitioning in anaphase B [Cell cycle control, cell division, chromosome partitioning]
    pfam01302
    Location:2487 → 2551
    CAP_GLY; CAP-Gly domain

  3. XM_030243199.2 → XP_030099059.1  centrosome-associated protein 350 isoform X5

    Conserved Domains (5) summary
    PTZ00121
    Location:1365 → 1812
    PTZ00121; MAEBL; Provisional
    COG5022
    Location:2092 → 2372
    COG5022; Myosin heavy chain [General function prediction only]
    COG5244
    Location:2528 → 2805
    NIP100; Dynactin complex subunit involved in mitotic spindle partitioning in anaphase B [Cell cycle control, cell division, chromosome partitioning]
    PTZ00108
    Location:1887 → 2148
    PTZ00108; DNA topoisomerase 2-like protein; Provisional
    pfam01302
    Location:2528 → 2592
    CAP_GLY; CAP-Gly domain

  4. XM_006529906.5 → XP_006529969.1  centrosome-associated protein 350 isoform X8

    Conserved Domains (4) summary
    TIGR01843
    Location:1318 → 1440
    type_I_hlyD; type I secretion membrane fusion protein, HlyD family
    PTZ00121
    Location:1565 → 2292
    PTZ00121; MAEBL; Provisional
    COG5244
    Location:2488 → 2765
    NIP100; Dynactin complex subunit involved in mitotic spindle partitioning in anaphase B [Cell cycle control, cell division, chromosome partitioning]
    pfam01302
    Location:2488 → 2552
    CAP_GLY; CAP-Gly domain

  5. XM_006529904.5 → XP_006529967.1  centrosome-associated protein 350 isoform X4

    Conserved Domains (7) summary
    TIGR01843
    Location:1318 → 1440
    type_I_hlyD; type I secretion membrane fusion protein, HlyD family
    PTZ00121
    Location:1486 → 1813
    PTZ00121; MAEBL; Provisional
    COG5022
    Location:2093 → 2373
    COG5022; Myosin heavy chain [General function prediction only]
    COG5244
    Location:2529 → 2806
    NIP100; Dynactin complex subunit involved in mitotic spindle partitioning in anaphase B [Cell cycle control, cell division, chromosome partitioning]
    PRK12704
    Location:1677 → 1779
    PRK12704; phosphodiesterase; Provisional
    PTZ00108
    Location:1888 → 2149
    PTZ00108; DNA topoisomerase 2-like protein; Provisional
    pfam01302
    Location:2529 → 2593
    CAP_GLY; CAP-Gly domain

  6. XM_030243200.2 → XP_030099060.1  centrosome-associated protein 350 isoform X7

    Conserved Domains (4) summary
    TIGR01843
    Location:1318 → 1440
    type_I_hlyD; type I secretion membrane fusion protein, HlyD family
    PTZ00121
    Location:1566 → 2293
    PTZ00121; MAEBL; Provisional
    COG5244
    Location:2489 → 2766
    NIP100; Dynactin complex subunit involved in mitotic spindle partitioning in anaphase B [Cell cycle control, cell division, chromosome partitioning]
    pfam01302
    Location:2489 → 2553
    CAP_GLY; CAP-Gly domain

  7. XM_006529902.5 → XP_006529965.1  centrosome-associated protein 350 isoform X2

    Conserved Domains (7) summary
    TIGR01843
    Location:1318 → 1440
    type_I_hlyD; type I secretion membrane fusion protein, HlyD family
    PTZ00121
    Location:1345 → 1814
    PTZ00121; MAEBL; Provisional
    COG5022
    Location:2094 → 2374
    COG5022; Myosin heavy chain [General function prediction only]
    COG5244
    Location:2530 → 2807
    NIP100; Dynactin complex subunit involved in mitotic spindle partitioning in anaphase B [Cell cycle control, cell division, chromosome partitioning]
    PRK12704
    Location:1678 → 1780
    PRK12704; phosphodiesterase; Provisional
    PTZ00108
    Location:1889 → 2150
    PTZ00108; DNA topoisomerase 2-like protein; Provisional
    pfam01302
    Location:2530 → 2594
    CAP_GLY; CAP-Gly domain

  8. XM_006529905.5 → XP_006529968.1  centrosome-associated protein 350 isoform X6

    Conserved Domains (4) summary
    PTZ00121
    Location:1336 → 1981
    PTZ00121; MAEBL; Provisional
    COG5244
    Location:2490 → 2767
    NIP100; Dynactin complex subunit involved in mitotic spindle partitioning in anaphase B [Cell cycle control, cell division, chromosome partitioning]
    pfam02463
    Location:1681 → 2324
    SMC_N; RecF/RecN/SMC N terminal domain
    pfam01302
    Location:2490 → 2554
    CAP_GLY; CAP-Gly domain

  9. XM_006529900.5 → XP_006529963.1  centrosome-associated protein 350 isoform X1

    Conserved Domains (5) summary
    PTZ00121
    Location:1336 → 1814
    PTZ00121; MAEBL; Provisional
    COG5022
    Location:2095 → 2375
    COG5022; Myosin heavy chain [General function prediction only]
    COG5244
    Location:2531 → 2808
    NIP100; Dynactin complex subunit involved in mitotic spindle partitioning in anaphase B [Cell cycle control, cell division, chromosome partitioning]
    PTZ00108
    Location:1890 → 2151
    PTZ00108; DNA topoisomerase 2-like protein; Provisional
    pfam01302
    Location:2531 → 2595
    CAP_GLY; CAP-Gly domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
E9Q309.1 GenPept UniProtKB/Swiss-Prot:E9Q309

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