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Steap2 six transmembrane epithelial antigen of prostate 2 [ Mus musculus (house mouse) ]

Gene ID: 74051, updated on 21-Apr-2024

Summary

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Official Symbol
Steap2provided by MGI
Official Full Name
six transmembrane epithelial antigen of prostate 2provided by MGI
Primary source
MGI:MGI:1921301
See related
Ensembl:ENSMUSG00000015653 AllianceGenome:MGI:1921301
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
STMP; IPCA1; IPCA-1; STAMP1; PCANAP1; 4921538B17Rik
Summary
Enables cupric reductase activity and ferric-chelate reductase (NADPH) activity. Acts upstream of or within copper ion import across plasma membrane; iron ion import across cell outer membrane; and iron ion import across plasma membrane. Located in endosome and plasma membrane. Is expressed in several structures, including brain; gut; metanephros; reproductive system; and respiratory system. Orthologous to human STEAP2 (STEAP2 metalloreductase). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in kidney adult (RPKM 8.7), cerebellum adult (RPKM 4.9) and 22 other tissues See more
Orthologs
human all
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Genomic context

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Location:
5 A1; 5 3.18 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (5714829..5744649, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (5664829..5694649, complement)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene family with sequence similarity 237, member B Neighboring gene cilia and flagella associated protein 69 Neighboring gene predicted gene, 40262 Neighboring gene STARR-seq mESC enhancer starr_12346 Neighboring gene STARR-seq mESC enhancer starr_12348 Neighboring gene STARR-seq mESC enhancer starr_12350 Neighboring gene STARR-seq mESC enhancer starr_12351 Neighboring gene six transmembrane epithelial antigen of the prostate 1 Neighboring gene predicted gene, 46900 Neighboring gene STARR-seq mESC enhancer starr_12352 Neighboring gene heat shock protein 8 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Overexpressing six-transmembrane protein of prostate 2 (STAMP2) alleviates sepsis-induced acute lung injury probably by hindering M1 macrophage polarization via the NF-κB pathway. Ji L, et al. Folia Histochem Cytobiol, 2023. PMID 36583372
  2. Membrane cholesterol modulates STEAP2 conformation during dynamic intracellular trafficking processes leading to broad subcellular distribution. Hasegawa H, et al. Exp Cell Res, 2018 Sep 15. PMID 29940176
  3. Differential expression and function of stamp family proteins in adipocyte differentiation. Sikkeland J, et al. PLoS One, 2013. PMID 23874564, Free PMC Article
  4. STAMPing at the crossroads of normal physiology and disease states. Sikkeland J, et al. Mol Cell Endocrinol, 2016 Apr 15. PMID 26911931
  5. Six-transmembrane epithelial antigen of the prostate (STEAP1 and STEAP2)-differentially expressed by murine and human mesenchymal stem cells. Vaghjiani RJ, et al. Tissue Eng Part A, 2009 Aug. PMID 19196137

See all (25) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Overexpressing six-transmembrane protein of prostate 2 (STAMP2) alleviates sepsis-induced acute lung injury probably by hindering M1 macrophage polarization via the NF-kappaB pathway.
    Title: Overexpressing six-transmembrane protein of prostate 2 (STAMP2) alleviates sepsis-induced acute lung injury probably by hindering M1 macrophage polarization via the NF-κB pathway.
  2. The conformational modulation of STEAP2 by the local membrane cholesterol content can therefore serve as a potential mechanism to modulate STEAP2 function in a compartment-restricted manner
    Title: Membrane cholesterol modulates STEAP2 conformation during dynamic intracellular trafficking processes leading to broad subcellular distribution.
  3. Stamp1 and Stamp2 play critical roles in adipogenesis, but through different mechanisms.
    Title: Differential expression and function of stamp family proteins in adipocyte differentiation.
  4. STEAPs may represent novel markers of mesenchymal stem cells in man as well as mice.
    Title: Six-transmembrane epithelial antigen of the prostate (STEAP1 and STEAP2)-differentially expressed by murine and human mesenchymal stem cells.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (3)  1 citation
  • Endonuclease-mediated (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables cupric reductase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cupric reductase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables ferric-chelate reductase (NADPH) activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ferric-chelate reductase (NADPH) activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in Golgi to plasma membrane transport ISO
Inferred from Sequence Orthology
more info
  
involved_in copper ion import IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within copper ion import IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within copper ion import across plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in endocytosis ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within iron ion import across cell outer membrane IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within iron ion import across plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within iron ion transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in regulated exocytosis ISO
Inferred from Sequence Orthology
more info
  
involved_in response to hormone ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in Golgi membrane ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in early endosome ISO
Inferred from Sequence Orthology
more info
  
is_active_in endosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in trans-Golgi network transport vesicle ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
metalloreductase STEAP2
NP_001096626.1
NP_001096627.1
NP_001272398.1
NP_001272399.1
NP_001272400.1
NP_083010.2
XP_011238977.1
XP_030110704.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001103156.2 → NP_001096626.1  metalloreductase STEAP2 isoform 1

    See identical proteins and their annotated locations for NP_001096626.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3, 4, and 5 encode the same isoform (1).
    Source sequence(s)
    AC092404, AK015015, AK052981, CJ122203
    Consensus CDS
    CCDS39007.1
    UniProtKB/Swiss-Prot
    Q3TS12, Q8BWB6
    UniProtKB/TrEMBL
    B2RX33, D3Z1C4
    Related
    ENSMUSP00000015797.5, ENSMUST00000015797.11
    Conserved Domains (2) summary
    COG2085
    Location:31 → 216
    COG2085; Predicted dinucleotide-binding enzyme [General function prediction only]
    pfam01794
    Location:261 → 404
    Ferric_reduct; Ferric reductase like transmembrane component

  2. NM_001103157.2 → NP_001096627.1  metalloreductase STEAP2 isoform 1

    See identical proteins and their annotated locations for NP_001096627.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2, 3, 4, and 5 encode the same isoform (1).
    Source sequence(s)
    AC092404, AK015015, AK052981, AK086787, CJ101909, CJ122203
    Consensus CDS
    CCDS39007.1
    UniProtKB/Swiss-Prot
    Q3TS12, Q8BWB6
    UniProtKB/TrEMBL
    B2RX33, D3Z1C4
    Related
    ENSMUSP00000111085.3, ENSMUST00000115425.9
    Conserved Domains (2) summary
    COG2085
    Location:31 → 216
    COG2085; Predicted dinucleotide-binding enzyme [General function prediction only]
    pfam01794
    Location:261 → 404
    Ferric_reduct; Ferric reductase like transmembrane component

  3. NM_001285469.1 → NP_001272398.1  metalloreductase STEAP2 isoform 1

    See identical proteins and their annotated locations for NP_001272398.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3, 4, and 5 encode the same isoform (1).
    Source sequence(s)
    AC092404
    Consensus CDS
    CCDS39007.1
    UniProtKB/Swiss-Prot
    Q3TS12, Q8BWB6
    UniProtKB/TrEMBL
    B2RX33, D3Z1C4
    Related
    ENSMUSP00000116910.2, ENSMUST00000148333.8
    Conserved Domains (2) summary
    COG2085
    Location:31 → 216
    COG2085; Predicted dinucleotide-binding enzyme [General function prediction only]
    pfam01794
    Location:261 → 404
    Ferric_reduct; Ferric reductase like transmembrane component

  4. NM_001285470.1 → NP_001272399.1  metalloreductase STEAP2 isoform 1

    See identical proteins and their annotated locations for NP_001272399.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3, 4, and 5 encode the same isoform (1).
    Source sequence(s)
    AC092404, AK015015, AK162343, CJ122203
    Consensus CDS
    CCDS39007.1
    UniProtKB/Swiss-Prot
    Q3TS12, Q8BWB6
    UniProtKB/TrEMBL
    B2RX33, D3Z1C4
    Related
    ENSMUSP00000111084.3, ENSMUST00000115424.9
    Conserved Domains (2) summary
    COG2085
    Location:31 → 216
    COG2085; Predicted dinucleotide-binding enzyme [General function prediction only]
    pfam01794
    Location:261 → 404
    Ferric_reduct; Ferric reductase like transmembrane component

  5. NM_001285471.1 → NP_001272400.1  metalloreductase STEAP2 isoform 2

    See identical proteins and their annotated locations for NP_001272400.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR and contains an alternate splice site in the 3' terminal exon, compared to variant 1. It encodes isoform 2, which has a shorter and distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AC092404
    Consensus CDS
    CCDS71541.1
    UniProtKB/TrEMBL
    D3YUM6, D3Z1C4
    Related
    ENSMUSP00000111087.2, ENSMUST00000115427.8
    Conserved Domains (3) summary
    COG2085
    Location:31 → 216
    COG2085; Predicted dinucleotide-binding enzyme [General function prediction only]
    pfam01794
    Location:261 → 395
    Ferric_reduct; Ferric reductase like transmembrane component
    pfam03807
    Location:33 → 118
    F420_oxidored; NADP oxidoreductase coenzyme F420-dependent

  6. NM_028734.5 → NP_083010.2  metalloreductase STEAP2 isoform 1

    See identical proteins and their annotated locations for NP_083010.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3, 4, and 5 encode the same isoform (1).
    Source sequence(s)
    AC092404, AK015015, AK052981
    Consensus CDS
    CCDS39007.1
    UniProtKB/Swiss-Prot
    Q3TS12, Q8BWB6
    UniProtKB/TrEMBL
    B2RX33, D3Z1C4
    Related
    ENSMUSP00000111086.3, ENSMUST00000115426.9
    Conserved Domains (2) summary
    COG2085
    Location:31 → 216
    COG2085; Predicted dinucleotide-binding enzyme [General function prediction only]
    pfam01794
    Location:261 → 404
    Ferric_reduct; Ferric reductase like transmembrane component

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    5714829..5744649 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030254844.2 → XP_030110704.1  metalloreductase STEAP2 isoform X1

    UniProtKB/Swiss-Prot
    Q3TS12, Q8BWB6
    UniProtKB/TrEMBL
    B2RX33, D3Z1C4
    Conserved Domains (2) summary
    COG2085
    Location:31 → 216
    COG2085; Predicted dinucleotide-binding enzyme [General function prediction only]
    pfam01794
    Location:261 → 404
    Ferric_reduct; Ferric reductase like transmembrane component

  2. XM_011240675.4 → XP_011238977.1  metalloreductase STEAP2 isoform X1

    See identical proteins and their annotated locations for XP_011238977.1

    UniProtKB/Swiss-Prot
    Q3TS12, Q8BWB6
    UniProtKB/TrEMBL
    B2RX33, D3Z1C4
    Conserved Domains (2) summary
    COG2085
    Location:31 → 216
    COG2085; Predicted dinucleotide-binding enzyme [General function prediction only]
    pfam01794
    Location:261 → 404
    Ferric_reduct; Ferric reductase like transmembrane component
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BWB6.1 GenPept UniProtKB/Swiss-Prot:Q8BWB6

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