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Pex26 peroxisomal biogenesis factor 26 [ Mus musculus (house mouse) ]

Gene ID: 74043, updated on 5-Mar-2024

Summary

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Official Symbol
Pex26provided by MGI
Official Full Name
peroxisomal biogenesis factor 26provided by MGI
Primary source
MGI:MGI:1921293
See related
Ensembl:ENSMUSG00000067825 AllianceGenome:MGI:1921293
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
4632428M11Rik
Summary
This gene is a member of the peroxin-26 family. The encoded protein is probably required for protein import into peroxisomes. It may anchor Pex1 and Pex6 to peroxisome membranes. Defects in a similar gene in human are the cause of peroxisome biogenesis disorder complementation group 8 (PBD-CG8). PBD refers to a group of four disorders: Zellweger syndrome (ZWS), neonatal adrenoleukodystrophy (NALD), infantile Refsum disease (IRD), and classical rhizomelic chondrodysplasia punctata (RCDP). Alternatively spliced transcript variants have been identified for this gene. [provided by RefSeq, Feb 2015]
Expression
Ubiquitous expression in ovary adult (RPKM 8.2), kidney adult (RPKM 7.2) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
6 F1; 6 57.13 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (121160176..121175796)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (121183217..121198837)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene microtubule associated monooxygenase, calponin and LIM domain containing 3 Neighboring gene multiple inositol polyphosphate histidine phosphatase 1, pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E3676 Neighboring gene predicted gene, 30842 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:121167996-121168280 Neighboring gene predicted gene, 38651 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:121176131-121176438 Neighboring gene tubulin, alpha 8

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The pathogenic peroxin Pex26p recruits the Pex1p-Pex6p AAA ATPase complexes to peroxisomes. Matsumoto N, et al. Nat Cell Biol, 2003 May. PMID 12717447
  2. High-throughput discovery of novel developmental phenotypes. Dickinson ME, et al. Nature, 2016 Sep 22. PMID 27626380, Free PMC Article
  3. The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Koscielny G, et al. Nucleic Acids Res, 2014 Jan. PMID 24194600, Free PMC Article
  4. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article
  5. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATPase binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ATPase binding ISO
Inferred from Sequence Orthology
more info
  
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
  
enables protein-membrane adaptor activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in protein import into peroxisome matrix IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein import into peroxisome matrix ISO
Inferred from Sequence Orthology
more info
  
involved_in protein import into peroxisome membrane IEA
Inferred from Electronic Annotation
more info
  
involved_in protein to membrane docking ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within protein transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in peroxisomal membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in peroxisome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in peroxisome ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
peroxisome assembly protein 26
Names
peroxin-26
peroxisome biogenesis factor 26

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001304773.1 → NP_001291702.1  peroxisome assembly protein 26 isoform 2

    See identical proteins and their annotated locations for NP_001291702.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' terminal exon compared to variant 1. It encodes isoform 2 which is shorter compared to isoform 1.
    Source sequence(s)
    AC153584, AK014598, AK042663, AK087637
    Consensus CDS
    CCDS80603.1
    UniProtKB/Swiss-Prot
    Q8BGI5
    Related
    ENSMUSP00000113233.2, ENSMUST00000120066.8
    Conserved Domains (1) summary
    pfam07163
    Location:1 → 301
    Pex26; Pex26 protein

  2. NM_001304774.1 → NP_001291703.1  peroxisome assembly protein 26 isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an exon in the central coding region, which results in a frameshift and an early stop codon, compared to variant 1. The encoded isoform (3) is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AC153584, AK014598, AK087637, AK145961
    Consensus CDS
    CCDS80604.1
    UniProtKB/TrEMBL
    D3Z3F5
    Related
    ENSMUSP00000113981.2, ENSMUST00000118234.8
    Conserved Domains (1) summary
    pfam07163
    Location:1 → 123
    Pex26; Pex26 protein

  3. NM_028730.6 → NP_083006.1  peroxisome assembly protein 26 isoform 1

    See identical proteins and their annotated locations for NP_083006.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC153584, AK014598, AK087637, BC058694
    Consensus CDS
    CCDS20488.1
    UniProtKB/Swiss-Prot
    Q3UGH5, Q8BGI5, Q9D661
    Related
    ENSMUSP00000085921.4, ENSMUST00000088561.10
    Conserved Domains (1) summary
    pfam07163
    Location:1 → 302
    Pex26; Pex26 protein

RNA

  1. NR_130903.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) uses an alternate 3' exon structure compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AK040411, AK087637

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    121160176..121175796
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017321782.2 → XP_017177271.1  peroxisome assembly protein 26 isoform X2

    UniProtKB/TrEMBL
    D3Z3F5
    Conserved Domains (1) summary
    pfam07163
    Location:1 → 123
    Pex26; Pex26 protein

  2. XM_036152361.1 → XP_036008254.1  peroxisome assembly protein 26 isoform X1

    Conserved Domains (1) summary
    pfam07163
    Location:1 → 211
    Pex26; Pex26 protein

  3. XM_006506703.5 → XP_006506766.1  peroxisome assembly protein 26 isoform X1

    Conserved Domains (1) summary
    pfam07163
    Location:1 → 211
    Pex26; Pex26 protein

RNA

  1. XR_004933625.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BGI5.2 GenPept UniProtKB/Swiss-Prot:Q8BGI5

Gene LinkOut

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