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Nfam1 Nfat activating molecule with ITAM motif 1 [ Mus musculus (house mouse) ]

Gene ID: 74039, updated on 19-Mar-2024

Summary

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Official Symbol
Nfam1provided by MGI
Official Full Name
Nfat activating molecule with ITAM motif 1provided by MGI
Primary source
MGI:MGI:1921289
See related
Ensembl:ENSMUSG00000058099 AllianceGenome:MGI:1921289
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Cnaip; 4921501M20Rik
Summary
Predicted to enable transmembrane signaling receptor activity. Involved in B cell differentiation and positive regulation of B cell receptor signaling pathway. Acts upstream of or within B cell receptor signaling pathway and regulation of B cell differentiation. Located in cell surface and membrane raft. Orthologous to human NFAM1 (NFAT activating protein with ITAM motif 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in spleen adult (RPKM 12.2), mammary gland adult (RPKM 6.6) and 20 other tissues See more
Orthologs
human all
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Genomic context

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See Nfam1 in Genome Data Viewer
Location:
15 E1; 15 39.01 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (82880937..82917598, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (82996736..83033397, complement)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene transcription factor 20 Neighboring gene CapStarr-seq enhancer MGSCv37_chr15:82805127-82805236 Neighboring gene microRNA 3080 Neighboring gene STARR-positive B cell enhancer mm9_chr15:82818187-82818488 Neighboring gene expressed sequence AW121686 Neighboring gene STARR-positive B cell enhancer ABC_E7401 Neighboring gene STARR-positive B cell enhancer ABC_E3149 Neighboring gene CapStarr-seq enhancer MGSCv37_chr15:82873210-82873393 Neighboring gene STARR-seq mESC enhancer starr_39309 Neighboring gene predicted gene, 32620 Neighboring gene STARR-positive B cell enhancer ABC_E3150 Neighboring gene predicted gene, 41366 Neighboring gene STARR-positive B cell enhancer ABC_E7402 Neighboring gene serine hydrolase-like Neighboring gene ribosomal RNA processing 7 homolog A

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. NFAM1 Promotes Pro-Inflammatory Cytokine Production in Mouse and Human Monocytes. Juchem KW, et al. Front Immunol, 2021. PMID 35095847, Free PMC Article
  2. Calcineurin/nuclear factors of activated T cells (NFAT)-activating and immunoreceptor tyrosine-based activation motif (ITAM)-containing protein (CNAIP), a novel ITAM-containing protein that activates the calcineurin/NFAT-signaling pathway. Yang J, et al. J Biol Chem, 2003 May 9. PMID 12615919
  3. Extracellular Vesicle-Derived circITGB1 Regulates Dendritic Cell Maturation and Cardiac Inflammation via miR-342-3p/NFAM1. Zhu J, et al. Oxid Med Cell Longev, 2022. PMID 35615580, Free PMC Article
  4. NFAM1, an immunoreceptor tyrosine-based activation motif-bearing molecule that regulates B cell development and signaling. Ohtsuka M, et al. Proc Natl Acad Sci U S A, 2004 May 25. PMID 15143214, Free PMC Article
  5. The Interleukin-2-mTORc1 Kinase Axis Defines the Signaling, Differentiation, and Metabolism of T Helper 1 and Follicular B Helper T Cells. Ray JP, et al. Immunity, 2015 Oct 20. PMID 26410627, Free PMC Article

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Extracellular Vesicle-Derived circITGB1 Regulates Dendritic Cell Maturation and Cardiac Inflammation via miR-342-3p/NFAM1.
    Title: Extracellular Vesicle-Derived circITGB1 Regulates Dendritic Cell Maturation and Cardiac Inflammation via miR-342-3p/NFAM1.
  2. NFAM1 modulates B cell signaling through its immunoreceptor tyrosine-based activation motif, which regulates B cell development
    Title: NFAM1, an immunoreceptor tyrosine-based activation motif-bearing molecule that regulates B cell development and signaling.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 
  • Endonuclease-mediated (3)  1 citation

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables transmembrane signaling receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transmembrane signaling receptor activity ISO
Inferred from Sequence Orthology
more info
  
enables transmembrane signaling receptor activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Process Evidence Code Pubs
involved_in B cell differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in B cell receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within B cell receptor signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in intracellular signal transduction ISO
Inferred from Sequence Orthology
more info
  
involved_in intracellular signal transduction ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in positive regulation of B cell receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of DNA-binding transcription factor activity ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of DNA-binding transcription factor activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in positive regulation of cytokine production IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within regulation of B cell differentiation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in signal transduction ISO
Inferred from Sequence Orthology
more info
  
involved_in signal transduction ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Component Evidence Code Pubs
located_in cell surface IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane ISO
Inferred from Sequence Orthology
more info
  
located_in membrane ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
is_active_in membrane raft IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane raft IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
NFAT activation molecule 1
Names
calcineurin/NFAT-activating ITAM-containing protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001271411.1 → NP_001258340.1  NFAT activation molecule 1 isoform a precursor

    See identical proteins and their annotated locations for NP_001258340.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
    Source sequence(s)
    AC133880, AK150635
    Consensus CDS
    CCDS70652.1
    UniProtKB/Swiss-Prot
    Q3UAX8, Q8R4V1, Q9D5Z3
    UniProtKB/TrEMBL
    Q3TBS2, Q3TD63
    Related
    ENSMUSP00000154945.2, ENSMUST00000231165.2

  2. NM_001271412.1 → NP_001258341.1  NFAT activation molecule 1 isoform b

    See identical proteins and their annotated locations for NP_001258341.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, uses an alternate splice site in the coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (b) is shorter and has a distinct N-terminus, compared to isoform a.
    Source sequence(s)
    AC133880, AK150635
    UniProtKB/TrEMBL
    Q3TC65, Q3TCT5

  3. NM_001271413.1 → NP_001258342.1  NFAT activation molecule 1 isoform c

    See identical proteins and their annotated locations for NP_001258342.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (c) has a shorter N-terminus, compared to isoform a. Variants 3 and 4 encode the same isoform (c).
    Source sequence(s)
    AK048992
    Consensus CDS
    CCDS70651.1
    UniProtKB/TrEMBL
    A7E2R9
    Related
    ENSMUSP00000023076.6, ENSMUST00000023076.6

  4. NM_001271414.1 → NP_001258343.1  NFAT activation molecule 1 isoform c

    See identical proteins and their annotated locations for NP_001258343.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (c) has a shorter N-terminus, compared to isoform a. Variants 3 and 4 encode the same isoform (c).
    Source sequence(s)
    AC129563, AK014802, AK048992
    Consensus CDS
    CCDS70651.1
    UniProtKB/TrEMBL
    A7E2R9

  5. NM_028728.3 → NP_083004.1  NFAT activation molecule 1 isoform d

    See identical proteins and their annotated locations for NP_083004.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR, contains multiple differences in the coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (d) is shorter and has a distinct N-terminus, compared to isoform a.
    Source sequence(s)
    AC129563, AK014802
    Consensus CDS
    CCDS27694.1
    UniProtKB/TrEMBL
    A7E2R9
    Related
    ENSMUSP00000105129.4, ENSMUST00000109503.10

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    82880937..82917598 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8R4V1.1 GenPept UniProtKB/Swiss-Prot:Q8R4V1

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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