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Sdr42e1 short chain dehydrogenase/reductase family 42E, member 1 [ Mus musculus (house mouse) ]

Gene ID: 74032, updated on 11-Apr-2024

Summary

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Official Symbol
Sdr42e1provided by MGI
Official Full Name
short chain dehydrogenase/reductase family 42E, member 1provided by MGI
Primary source
MGI:MGI:1921282
See related
Ensembl:ENSMUSG00000034308 AllianceGenome:MGI:1921282
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
4632417N05Rik
Summary
Predicted to enable oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor. Predicted to be involved in steroid biosynthetic process. Predicted to be located in membrane. Predicted to be integral component of membrane. Is expressed in several structures, including brain; integumental system; limb; liver; and musculoskeletal system. Orthologous to human SDR42E1 (short chain dehydrogenase/reductase family 42E, member 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in liver adult (RPKM 39.3), bladder adult (RPKM 18.5) and 12 other tissues See more
Orthologs
human all
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Genomic context

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Location:
8 E1; 8 64.69 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (118388138..118400428, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (117661399..117673689, complement)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene c-Maf inducing protein Neighboring gene microRNA 7078 Neighboring gene STARR-positive B cell enhancer ABC_E11399 Neighboring gene phospholipase C, gamma 2 Neighboring gene predicted gene, 31717 Neighboring gene predicted gene, 38416

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
  2. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548
  3. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article
  4. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
  5. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 3-beta-hydroxy-delta5-steroid dehydrogenase activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in steroid biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
short-chain dehydrogenase/reductase family 42E member 1
NP_001344201.1
NP_001344202.1
NP_083001.1
XP_006531472.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001357272.1 → NP_001344201.1  short-chain dehydrogenase/reductase family 42E member 1

    Status: VALIDATED

    Source sequence(s)
    AC112964, AK014586, CX243765
    Consensus CDS
    CCDS22701.1
    UniProtKB/Swiss-Prot
    Q8VCV0, Q9D665
    Conserved Domains (1) summary
    cl21454
    Location:10 → 351
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

  2. NM_001357273.1 → NP_001344202.1  short-chain dehydrogenase/reductase family 42E member 1

    Status: VALIDATED

    Source sequence(s)
    AC112964
    Consensus CDS
    CCDS22701.1
    UniProtKB/Swiss-Prot
    Q8VCV0, Q9D665
    Related
    ENSMUSP00000133782.2, ENSMUST00000173522.8
    Conserved Domains (1) summary
    cl21454
    Location:10 → 351
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

  3. NM_028725.4 → NP_083001.1  short-chain dehydrogenase/reductase family 42E member 1

    See identical proteins and their annotated locations for NP_083001.1

    Status: VALIDATED

    Source sequence(s)
    AC112964
    Consensus CDS
    CCDS22701.1
    UniProtKB/Swiss-Prot
    Q8VCV0, Q9D665
    Related
    ENSMUSP00000044457.8, ENSMUST00000037955.14
    Conserved Domains (1) summary
    cl21454
    Location:10 → 351
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    118388138..118400428 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006531409.3 → XP_006531472.1  short-chain dehydrogenase/reductase family 42E member 1 isoform X1

    See identical proteins and their annotated locations for XP_006531472.1

    UniProtKB/Swiss-Prot
    Q8VCV0, Q9D665
    Conserved Domains (1) summary
    cl21454
    Location:10 → 351
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9D665.1 GenPept UniProtKB/Swiss-Prot:Q9D665

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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