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Glyr1 glyoxylate reductase 1 homolog (Arabidopsis) [ Mus musculus (house mouse) ]

Gene ID: 74022, updated on 11-Apr-2024

Summary

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Official Symbol
Glyr1provided by MGI
Official Full Name
glyoxylate reductase 1 homolog (Arabidopsis)provided by MGI
Primary source
MGI:MGI:1921272
See related
Ensembl:ENSMUSG00000022536 AllianceGenome:MGI:1921272
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
NDF; Npac; 2810419J22Rik; 3930401K13Rik
Summary
Enables DNA binding activity and chromatin binding activity. Predicted to be involved in positive regulation of histone acetylation and positive regulation of transcription by RNA polymerase II. Predicted to be located in cytosol and nucleoplasm. Predicted to be part of nucleosome. Is expressed in several structures, including central nervous system; early conceptus; gonad; and retina. Orthologous to human GLYR1 (glyoxylate reductase 1 homolog). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E14 (RPKM 46.0), whole brain E14.5 (RPKM 44.6) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
16 A1; 16 2.49 cM
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (4831766..4867780, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (5013902..5049938, complement)

Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E7426 Neighboring gene small integral membrane protein 22 Neighboring gene rogdi homolog Neighboring gene STARR-positive B cell enhancer ABC_E1180 Neighboring gene ubinuclein 1 Neighboring gene predicted gene, 23483 Neighboring gene transmembrane protein 126A pseudogene Neighboring gene periplakin

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Npac Is A Co-factor of Histone H3K36me3 and Regulates Transcriptional Elongation in Mouse Embryonic Stem Cells. Yu S, et al. Genomics Proteomics Bioinformatics, 2022 Feb. PMID 33676077, Free PMC Article
  2. NDF, a nucleosome-destabilizing factor that facilitates transcription through nucleosomes. Fei J, et al. Genes Dev, 2018 May 1. PMID 29759984, Free PMC Article
  3. The mouse mahoganoid coat color mutation disrupts a novel C3HC4 RING domain protein. Phan LK, et al. J Clin Invest, 2002 Nov. PMID 12438443, Free PMC Article
  4. Large-scale screen for genes involved in gonad development. Wertz K, et al. Mech Dev, 2000 Nov. PMID 11044607
  5. Activity-dependent neuroprotective protein recruits HP1 and CHD4 to control lineage-specifying genes. Ostapcuk V, et al. Nature, 2018 May. PMID 29795351

See all (32) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Npac Is A Co-factor of Histone H3K36me3 and Regulates Transcriptional Elongation in Mouse Embryonic Stem Cells.
    Title: Npac Is A Co-factor of Histone H3K36me3 and Regulates Transcriptional Elongation in Mouse Embryonic Stem Cells.
  2. Transcription factor protein interactomes reveal genetic determinants in heart disease.
    Title: Transcription factor protein interactomes reveal genetic determinants in heart disease.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables NAD binding IEA
Inferred from Electronic Annotation
more info
  
enables NADP binding IEA
Inferred from Electronic Annotation
more info
  
enables chromatin binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables chromatin binding ISO
Inferred from Sequence Orthology
more info
  
enables chromatin-protein adaptor activity ISO
Inferred from Sequence Orthology
more info
  
enables histone binding ISO
Inferred from Sequence Orthology
more info
  
enables methylated histone binding ISO
Inferred from Sequence Orthology
more info
  
enables nucleosome binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables nucleosome binding ISO
Inferred from Sequence Orthology
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in transcription elongation-coupled chromatin remodeling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in transcription elongation-coupled chromatin remodeling ISO
Inferred from Sequence Orthology
more info
  
involved_in transcription initiation-coupled chromatin remodeling ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of chromatin IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of chromatin ISO
Inferred from Sequence Orthology
more info
  
located_in chromosome IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
part_of nucleosome ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
cytokine-like nuclear factor N-PAC
Names
cytokine-like nuclear factor n-pac
nuclear protein NP60
putative oxidoreductase GLYR1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001079814.1 → NP_001073282.1  cytokine-like nuclear factor N-PAC isoform 1

    See identical proteins and their annotated locations for NP_001073282.1

    Status: VALIDATED

    Source sequence(s)
    AC163723, AI854082, AK151832, BY135011, CF174076
    Consensus CDS
    CCDS37244.1
    UniProtKB/TrEMBL
    D3YYT1
    Related
    ENSMUSP00000111510.2, ENSMUST00000115844.3
    Conserved Domains (3) summary
    cd05836
    Location:6 → 90
    N_Pac_NP60; The PWWP domain is an essential part of the cytokine-like nuclear factor n-pac protein, or NP60, which enhances the activity of MAP2K4 and MAP2K6 kinases to phosphorylate p38-alpha. In a variety of cell lines, NP60 has been shown to localize to the ...
    COG2084
    Location:267 → 550
    MmsB; 3-hydroxyisobutyrate dehydrogenase or related beta-hydroxyacid dehydrogenase [Lipid transport and metabolism]
    cl25423
    Location:209 → 301
    NAD_bind_amino_acid_DH; NAD(P) binding domain of amino acid dehydrogenase-like proteins

  2. NM_001359747.1 → NP_001346676.1  cytokine-like nuclear factor N-PAC isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC163723
    Conserved Domains (2) summary
    COG2084
    Location:198 → 475
    MmsB; 3-hydroxyisobutyrate dehydrogenase or related beta-hydroxyacid dehydrogenase [Lipid transport and metabolism]
    cl02554
    Location:1 → 21
    PWWP; The PWWP domain, named for a conserved Pro-Trp-Trp-Pro motif, is a small domain consisting of 100-150 amino acids. The PWWP domain is found in numerous proteins that are involved in cell division, growth and differentiation. Most PWWP-domain proteins ...

  3. NM_001359748.1 → NP_001346677.1  cytokine-like nuclear factor N-PAC isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC163723
    Conserved Domains (3) summary
    COG2084
    Location:198 → 481
    MmsB; 3-hydroxyisobutyrate dehydrogenase or related beta-hydroxyacid dehydrogenase [Lipid transport and metabolism]
    cl02554
    Location:1 → 21
    PWWP; The PWWP domain, named for a conserved Pro-Trp-Trp-Pro motif, is a small domain consisting of 100-150 amino acids. The PWWP domain is found in numerous proteins that are involved in cell division, growth and differentiation. Most PWWP-domain proteins ...
    cl25423
    Location:140 → 232
    NAD_bind_amino_acid_DH; NAD(P) binding domain of amino acid dehydrogenase-like proteins

  4. NM_028720.2 → NP_082996.2  cytokine-like nuclear factor N-PAC isoform 2

    See identical proteins and their annotated locations for NP_082996.2

    Status: VALIDATED

    Source sequence(s)
    AI854082, AK152887, AK159476, BY135011
    Consensus CDS
    CCDS27930.1
    UniProtKB/Swiss-Prot
    Q3TX02, Q922P9, Q9CYQ1
    Related
    ENSMUSP00000023189.8, ENSMUST00000023189.15
    Conserved Domains (2) summary
    cd05836
    Location:6 → 90
    N_Pac_NP60; The PWWP domain is an essential part of the cytokine-like nuclear factor n-pac protein, or NP60, which enhances the activity of MAP2K4 and MAP2K6 kinases to phosphorylate p38-alpha. In a variety of cell lines, NP60 has been shown to localize to the ...
    COG2084
    Location:267 → 544
    MmsB; 3-hydroxyisobutyrate dehydrogenase or related beta-hydroxyacid dehydrogenase [Lipid transport and metabolism]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000082.7 Reference GRCm39 C57BL/6J

    Range
    4831766..4867780 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030249304.2 → XP_030105164.1  cytokine-like nuclear factor N-PAC isoform X2

    Conserved Domains (2) summary
    cd05836
    Location:6 → 90
    N_Pac_NP60; The PWWP domain is an essential part of the cytokine-like nuclear factor n-pac protein, or NP60, which enhances the activity of MAP2K4 and MAP2K6 kinases to phosphorylate p38-alpha. In a variety of cell lines, NP60 has been shown to localize to the ...
    COG2084
    Location:187 → 464
    MmsB; 3-hydroxyisobutyrate dehydrogenase or related beta-hydroxyacid dehydrogenase [Lipid transport and metabolism]

  2. XM_030249303.2 → XP_030105163.1  cytokine-like nuclear factor N-PAC isoform X1

    Conserved Domains (3) summary
    cd05836
    Location:6 → 90
    N_Pac_NP60; The PWWP domain is an essential part of the cytokine-like nuclear factor n-pac protein, or NP60, which enhances the activity of MAP2K4 and MAP2K6 kinases to phosphorylate p38-alpha. In a variety of cell lines, NP60 has been shown to localize to the ...
    COG2084
    Location:187 → 470
    MmsB; 3-hydroxyisobutyrate dehydrogenase or related beta-hydroxyacid dehydrogenase [Lipid transport and metabolism]
    cl21454
    Location:129 → 221
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

  3. XM_036160153.1 → XP_036016046.1  cytokine-like nuclear factor N-PAC isoform X3

    Conserved Domains (2) summary
    cd05836
    Location:6 → 90
    N_Pac_NP60; The PWWP domain is an essential part of the cytokine-like nuclear factor n-pac protein, or NP60, which enhances the activity of MAP2K4 and MAP2K6 kinases to phosphorylate p38-alpha. In a variety of cell lines, NP60 has been shown to localize to the ...
    cl21454
    Location:268 → 349
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

RNA

  1. XR_003951842.2 RNA Sequence

  2. XR_004939249.1 RNA Sequence

  3. XR_004939250.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q922P9.1 GenPept UniProtKB/Swiss-Prot:Q922P9

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