Traf3ip1 TRAF3 interacting protein 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Traf3ip1provided by MGI
Official Full Name: TRAF3 interacting protein 1provided by MGI
Primary source: MGI:MGI:1921269
See related: Ensembl:ENSMUSG00000034292 AllianceGenome:MGI:1921269
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: MIP-T3; 3930402D05Rik
Summary: Predicted to enable microtubule binding activity and signaling receptor binding activity. Involved in morphogenesis of a polarized epithelium and regulation of microtubule cytoskeleton organization. Acts upstream of or within several processes, including embryonic organ development; negative regulation of interferon-beta production; and negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning. Located in axoneme; centrosome; and ciliary basal body. Part of intraciliary transport particle B. Is expressed in genitourinary system and nose. Human ortholog(s) of this gene implicated in Senior-Loken syndrome. Orthologous to human TRAF3IP1 (TRAF3 interacting protein 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in testis adult (RPKM 7.5), CNS E11.5 (RPKM 5.8) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 1 D; 1 46.16 cM

Exon count:: 19

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	1	NC_000067.7 (91422311..91457029)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	1	NC_000067.6 (91494590..91529307)

Chromosome 1 - NC_000067.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Homozygous Traf3ip1 mutants are not viable and have both neural developmental defects and polydactyly, phenotypes typical of mutants with ciliary assembly defects.
Title: Mutations in Traf3ip1 reveal defects in ciliogenesis, embryonic development, and altered cell size regulation.
Data show that overexpression of IFT54/Traf3ip1 displaces IFT20 from the Golgi apparatus. IFT54s effect on IFT20 is a dominant negative phenotype caused by its overexpression.
Title: Characterization of mouse IFT complex B.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (1)
Endonuclease-mediated (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables microtubule binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables signaling receptor binding	ISO Inferred from Sequence Orthology more info
enables tubulin binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cell projection organization	IEA Inferred from Electronic Annotation more info
involved_in cilium assembly	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cilium assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cilium assembly	NAS Non-traceable Author Statement more info	PubMed
acts_upstream_of defense response to virus	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within embryonic camera-type eye development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within embryonic digit morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within embryonic heart tube development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of interferon-beta production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intraciliary anterograde transport	NAS Non-traceable Author Statement more info	PubMed
involved_in intraciliary transport	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within intraciliary transport	IC Inferred by Curator more info	PubMed
involved_in kidney development	ISO Inferred from Sequence Orthology more info
involved_in morphogenesis of a polarized epithelium	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in morphogenesis of a polarized epithelium	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of defense response to virus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of defense response to virus	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of interferon-beta production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of protein phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of protein-containing complex assembly	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of smoothened signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of type I interferon production	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of tyrosine phosphorylation of STAT protein	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within neural tube patterning	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within post-anal tail morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of DNA binding	ISO Inferred from Sequence Orthology more info
involved_in regulation of microtubule cytoskeleton organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of microtubule cytoskeleton organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of microtubule cytoskeleton organization	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in axoneme	IBA Inferred from Biological aspect of Ancestor more info
located_in axoneme	IDA Inferred from Direct Assay more info	PubMed
located_in cell projection	IEA Inferred from Electronic Annotation more info
is_active_in centrosome	IBA Inferred from Biological aspect of Ancestor more info
located_in centrosome	IDA Inferred from Direct Assay more info	PubMed
is_active_in ciliary basal body	IBA Inferred from Biological aspect of Ancestor more info
located_in ciliary basal body	IDA Inferred from Direct Assay more info	PubMed
located_in ciliary base	ISO Inferred from Sequence Orthology more info
located_in ciliary tip	ISO Inferred from Sequence Orthology more info
located_in ciliary transition zone	ISO Inferred from Sequence Orthology more info
located_in cilium	IDA Inferred from Direct Assay more info	PubMed
located_in cilium	NAS Non-traceable Author Statement more info	PubMed
located_in cilium	TAS Traceable Author Statement more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
part_of intraciliary transport particle B	IBA Inferred from Biological aspect of Ancestor more info
part_of intraciliary transport particle B	IDA Inferred from Direct Assay more info	PubMed
part_of intraciliary transport particle B	ISO Inferred from Sequence Orthology more info
located_in microtubule cytoskeleton	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: TRAF3-interacting protein 1

Names: TNF receptor-associated factor 3 interacting protein 1; intraflagellar transport protein 54 homolog; microtubule-interacting protein associated with TRAF3; microtubule-interacting protein that associates with TRAF3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_028718.2 → NP_082994.1 TRAF3-interacting protein 1

See identical proteins and their annotated locations for NP_082994.1

Status: VALIDATED

Source sequence(s)

AY613437, BC051115, BY739359, CK794620

Consensus CDS

CCDS35664.1

UniProtKB/Swiss-Prot

Q149C2, Q538H5, Q80VQ3, Q9CS98

Related

ENSMUSP00000042391.8, ENSMUST00000047242.9

Conserved Domains (1) summary

pfam10243
Location:49 → 619

MIP-T3; Microtubule-binding protein MIP-T3

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000067.7 Reference GRCm39 C57BL/6J

Range

91422311..91457029

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036153864.1 → XP_036009757.1 TRAF3-interacting protein 1 isoform X1

Conserved Domains (3) summary

PTZ00121
Location:118 → 392

PTZ00121; MAEBL; Provisional

pfam10243
Location:5 → 117

MIP-T3; Microtubule-binding protein MIP-T3

pfam17749
Location:552 → 706

MIP-T3_C; Microtubule-binding protein MIP-T3 C-terminal region
XM_036153867.1 → XP_036009760.1 TRAF3-interacting protein 1 isoform X2

Conserved Domains (3) summary

PTZ00121
Location:100 → 362

PTZ00121; MAEBL; Provisional

pfam10243
Location:5 → 117

MIP-T3; Microtubule-binding protein MIP-T3

pfam17749
Location:528 → 682

MIP-T3_C; Microtubule-binding protein MIP-T3 C-terminal region
XM_006529896.2 → XP_006529959.1 TRAF3-interacting protein 1 isoform X3

Conserved Domains (3) summary

PTZ00121
Location:100 → 672

PTZ00121; MAEBL; Provisional

pfam10243
Location:5 → 117

MIP-T3; Microtubule-binding protein MIP-T3

pfam17749
Location:518 → 672

MIP-T3_C; Microtubule-binding protein MIP-T3 C-terminal region
XM_006529898.2 → XP_006529961.1 TRAF3-interacting protein 1 isoform X4

UniProtKB/TrEMBL

A0A087WQD8

Related

ENSMUSP00000140151.2, ENSMUST00000189341.7

Conserved Domains (3) summary

PTZ00121
Location:100 → 648

PTZ00121; MAEBL; Provisional

pfam10243
Location:5 → 117

MIP-T3; Microtubule-binding protein MIP-T3

pfam17749
Location:494 → 648

MIP-T3_C; Microtubule-binding protein MIP-T3 C-terminal region