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Phf19 PHD finger protein 19 [ Mus musculus (house mouse) ]

Gene ID: 74016, updated on 11-Apr-2024

Summary

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Official Symbol
Phf19provided by MGI
Official Full Name
PHD finger protein 19provided by MGI
Primary source
MGI:MGI:1921266
See related
Ensembl:ENSMUSG00000026873 AllianceGenome:MGI:1921266
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
3110009G19Rik; 3321402G02Rik
Summary
Enables methylated histone binding activity. Involved in several processes, including negative regulation of transcription by RNA polymerase II; positive regulation of histone H3-K27 methylation; and stem cell population maintenance. Part of ESC/E(Z) complex. Is expressed in brain ventricular layer; early conceptus; eye; genitourinary system; and intestine. Orthologous to human PHF19 (PHD finger protein 19). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in thymus adult (RPKM 5.0), genital fat pad adult (RPKM 4.1) and 25 other tissues See more
Orthologs
human all
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Genomic context

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See Phf19 in Genome Data Viewer
Location:
2 B; 2 23.02 cM
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (34783764..34804365, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (34893752..34914353, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene proteasome (prosome, macropain) 26S subunit, non-ATPase, 5 Neighboring gene STARR-positive B cell enhancer ABC_E3369 Neighboring gene cutA divalent cation tolerance homolog-like Neighboring gene STARR-positive B cell enhancer ABC_E1003 Neighboring gene predicted gene, 24905 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:34794663-34794772 Neighboring gene STARR-seq mESC enhancer starr_04273 Neighboring gene TNF receptor-associated factor 1 Neighboring gene STARR-positive B cell enhancer ABC_E7809 Neighboring gene predicted gene, 52552

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Structural basis for histone variant H3tK27me3 recognition by PHF1 and PHF19. Dong C, et al. Elife, 2020 Sep 1. PMID 32869745, Free PMC Article
  2. The Polycomb-associated factor PHF19 controls hematopoietic stem cell state and differentiation. Vizán P, et al. Sci Adv, 2020 Aug. PMID 32821835, Free PMC Article
  3. PHF19 promotes multiple myeloma tumorigenicity through PRC2 activation and broad H3K27me3 domain formation. Ren Z, et al. Blood, 2019 Oct 3. PMID 31383640, Free PMC Article
  4. miR-155 harnesses Phf19 to potentiate cancer immunotherapy through epigenetic reprogramming of CD8(+) T cell fate. Ji Y, et al. Nat Commun, 2019 May 14. PMID 31089138, Free PMC Article
  5. PHD Finger Protein 19 Promotes Cardiac Hypertrophy via Epigenetically Regulating SIRT2. Gu W, et al. Cardiovasc Toxicol, 2021 Jun. PMID 33611744, Free PMC Article

See all (29) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. PHD Finger Protein 19 Promotes Cardiac Hypertrophy via Epigenetically Regulating SIRT2.
    Title: PHD Finger Protein 19 Promotes Cardiac Hypertrophy via Epigenetically Regulating SIRT2.
  2. Structural basis for histone variant H3tK27me3 recognition by PHF1 and PHF19.
    Title: Structural basis for histone variant H3tK27me3 recognition by PHF1 and PHF19.
  3. PHF19 is required for multiple myeloma tumorigenesis in vivo.
    Title: PHF19 promotes multiple myeloma tumorigenicity through PRC2 activation and broad H3K27me3 domain formation.
  4. In B16 mouse melanoma model miR-155 enhances Polycomb repressor complex 2 (PRC2) activity indirectly by promoting the expression of the PRC2-associated factor Phf19 through downregulation of the Akt inhibitor, Ship1. Phf19 orchestrates a transcriptional program extensively shared with miR-155 to restrain T cell senescence and sustain CD8+ T cell antitumor responses.
    Title: miR-155 harnesses Phf19 to potentiate cancer immunotherapy through epigenetic reprogramming of CD8(+) T cell fate.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (4)  1 citation
  • Endonuclease-mediated (2) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables chromatin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables methylated histone binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables methylated histone binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables methylated histone binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within chromatin organization IEA
Inferred from Electronic Annotation
more info
  
involved_in epigenetic regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of gene expression, epigenetic IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of gene expression, epigenetic IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of gene expression, epigenetic ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in stem cell differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in stem cell population maintenance IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of ESC/E(Z) complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of ESC/E(Z) complex ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
PHD finger protein 19
Names
polycomb-like protein 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001418754.1 → NP_001405683.1  PHD finger protein 19 isoform a

    Status: VALIDATED

    Source sequence(s)
    AL929068
    UniProtKB/Swiss-Prot
    Q9CXG9

  2. NM_001418755.1 → NP_001405684.1  PHD finger protein 19 isoform b

    Status: VALIDATED

    Source sequence(s)
    AL929068

  3. NM_001418756.1 → NP_001405685.1  PHD finger protein 19 isoform c

    Status: VALIDATED

    Source sequence(s)
    AL929068

  4. NM_028716.5 → NP_082992.1  PHD finger protein 19 isoform a

    See identical proteins and their annotated locations for NP_082992.1

    Status: VALIDATED

    Source sequence(s)
    AL929068
    Consensus CDS
    CCDS15955.1
    UniProtKB/Swiss-Prot
    Q9CXG9
    Related
    ENSMUSP00000028232.4, ENSMUST00000028232.7
    Conserved Domains (4) summary
    cd15581
    Location:195 → 246
    PHD2_PHF19; PHD finger 2 found in PHD finger protein 19 (PHF19)
    pfam14061
    Location:529 → 576
    Mtf2_C; Polycomb-like MTF2 factor 2
    pfam18104
    Location:41 → 76
    Tudor_2; Jumonji domain-containing protein 2A Tudor domain
    cl22851
    Location:96 → 148
    PHD_SF; PHD finger superfamily

RNA

  1. NR_184813.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL929068

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    34783764..34804365 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006498380.2 → XP_006498443.1  PHD finger protein 19 isoform X3

    Conserved Domains (2) summary
    cd15581
    Location:43 → 94
    PHD2_PHF19; PHD finger 2 found in PHD finger protein 19 (PHF19)
    pfam14061
    Location:377 → 424
    Mtf2_C; Polycomb-like MTF2 factor 2

  2. XM_036162623.1 → XP_036018516.1  PHD finger protein 19 isoform X2

    Conserved Domains (3) summary
    cd15581
    Location:95 → 146
    PHD2_PHF19; PHD finger 2 found in PHD finger protein 19 (PHF19)
    pfam14061
    Location:429 → 476
    Mtf2_C; Polycomb-like MTF2 factor 2
    cl22851
    Location:1 → 48
    PHD_SF; PHD finger superfamily

  3. XM_036162624.1 → XP_036018517.1  PHD finger protein 19 isoform X4

    Conserved Domains (2) summary
    cd15581
    Location:24 → 75
    PHD2_PHF19; PHD finger 2 found in PHD finger protein 19 (PHF19)
    pfam14061
    Location:358 → 405
    Mtf2_C; Polycomb-like MTF2 factor 2

  4. XM_006498381.1 → XP_006498444.1  PHD finger protein 19 isoform X4

    Related
    ENSMUST00000128663.8
    Conserved Domains (2) summary
    cd15581
    Location:24 → 75
    PHD2_PHF19; PHD finger 2 found in PHD finger protein 19 (PHF19)
    pfam14061
    Location:358 → 405
    Mtf2_C; Polycomb-like MTF2 factor 2

RNA

  1. XR_004940748.1 RNA Sequence

  2. XR_004940750.1 RNA Sequence

  3. XR_004940751.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9CXG9.1 GenPept UniProtKB/Swiss-Prot:Q9CXG9

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