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Slc25a27 solute carrier family 25, member 27 [ Mus musculus (house mouse) ]

Gene ID: 74011, updated on 5-Mar-2024

Summary

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Official Symbol
Slc25a27provided by MGI
Official Full Name
solute carrier family 25, member 27provided by MGI
Primary source
MGI:MGI:1921261
See related
Ensembl:ENSMUSG00000023912 AllianceGenome:MGI:1921261
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ucp4; UCP 4; 3632410G24Rik; 9430092A03Rik; D530043E16Rik
Summary
Predicted to be involved in several processes, including cellular chemical homeostasis; negative regulation of mitochondrial membrane potential; and regulation of glucose import. Located in mitochondrion. Is expressed in central nervous system; dorsal root ganglion; neural retina; and trigeminal nerve. Human ortholog(s) of this gene implicated in schizophrenia. Orthologous to human SLC25A27 (solute carrier family 25 member 27). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in CNS E14 (RPKM 9.6), CNS E18 (RPKM 8.3) and 15 other tissues See more
Orthologs
human all
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Genomic context

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Location:
17 B3; 17 19.75 cM
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (43948630..43978105, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (43637739..43667214, complement)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma) Neighboring gene RIKEN cDNA 1700071M16 gene Neighboring gene STARR-seq mESC enhancer starr_42598 Neighboring gene tudor domain containing 6 Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:43782177-43782395 Neighboring gene cytochrome P450, family 39, subfamily a, polypeptide 1 Neighboring gene STARR-positive B cell enhancer mm9_chr17:43837943-43838243 Neighboring gene predicted gene, 25783 Neighboring gene STARR-seq mESC enhancer starr_42600 Neighboring gene STARR-seq mESC enhancer starr_42601 Neighboring gene predicted gene, 41581

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Overexpression of UCP4 in astrocytic mitochondria prevents multilevel dysfunctions in a mouse model of Alzheimer's disease. Rosenberg N, et al. Glia, 2023 Apr. PMID 36537556
  2. Superresolution microscopy reveals spatial separation of UCP4 and F0F1-ATP synthase in neuronal mitochondria. Klotzsch E, et al. Proc Natl Acad Sci U S A, 2015 Jan 6. PMID 25535394, Free PMC Article
  3. Control of mitochondrial pH by uncoupling protein 4 in astrocytes promotes neuronal survival. Perreten Lambert H, et al. J Biol Chem, 2014 Nov 7. PMID 25237189, Free PMC Article
  4. Mitochondrial dysfunction is induced by the overexpression of UCP4 in 3T3-L1 adipocytes. Gao CL, et al. Int J Mol Med, 2010 Jan. PMID 19956904
  5. Uncoupling protein 2 and 4 expression pattern during stem cell differentiation provides new insight into their putative function. Rupprecht A, et al. PLoS One, 2014. PMID 24523901, Free PMC Article

See all (26) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Ucp4 Knockdown of Cerebellar Purkinje Cells Induces Bradykinesia.
    Title: Ucp4 Knockdown of Cerebellar Purkinje Cells Induces Bradykinesia.
  2. Overexpression of UCP4 in astrocytic mitochondria prevents multilevel dysfunctions in a mouse model of Alzheimer's disease.
    Title: Overexpression of UCP4 in astrocytic mitochondria prevents multilevel dysfunctions in a mouse model of Alzheimer's disease.
  3. our results suggested DJ-1 might regulate the expression of UCP4 by oxidation of DJ-1 and partially via NF-kappaB pathway in its protective response to oxidative stress
    Title: Parkinson's disease-related DJ-1 modulates the expression of uncoupling protein 4 against oxidative stress.
  4. UCP4 may dissipate the excessive proton gradient, which is usually associated with reactive oxygen species production.
    Title: Superresolution microscopy reveals spatial separation of UCP4 and F0F1-ATP synthase in neuronal mitochondria.
  5. astrocytes expressing more UCP4 produce more lactate, which is used as an energy source by neurons, and have the ability to enhance neuronal survival
    Title: Control of mitochondrial pH by uncoupling protein 4 in astrocytes promotes neuronal survival.
  6. UCP2 is present in cells with highly proliferative potential, which have a glycolytic type of metabolism as a common feature, whereas UCP4 is strongly associated with non-proliferative highly differentiated neuronal cells
    Title: Uncoupling protein 2 and 4 expression pattern during stem cell differentiation provides new insight into their putative function.
  7. Adipocytes overexpressing UcpP4 showed decreased mitochondrial copy number (mtDNA) and lower mRNA expression of key factors in mitochondrial biogenesis, including PGC-1alpha and mtTFA.
    Title: Mitochondrial dysfunction is induced by the overexpression of UCP4 in 3T3-L1 adipocytes.
  8. Results suggest that mitochondrial UCP4 mediates an adaptive shift in energy metabolism and increases the resistance of neurons to metabolic and oxidative stress.
    Title: Mitochondrial UCP4 mediates an adaptive shift in energy metabolism and increases the resistance of neurons to metabolic and oxidative stress.
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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables chloride transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
  
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
  
enables proton transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
  
enables transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in intracellular triglyceride homeostasis ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of mitochondrial calcium ion concentration ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of mitochondrial membrane potential ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within negative regulation of neuron apoptotic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of glucose import ISO
Inferred from Sequence Orthology
more info
  
involved_in response to cold IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in apical part of cell ISO
Inferred from Sequence Orthology
more info
  
located_in cell projection IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrial inner membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrial membrane ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrion HDA PubMed 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  
located_in neuronal cell body ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
mitochondrial uncoupling protein 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001357122.1 → NP_001344051.1  mitochondrial uncoupling protein 4 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC154647, AU254602
    UniProtKB/TrEMBL
    Q9CX10
    Conserved Domains (1) summary
    pfam00153
    Location:122 → 218
    Mito_carr; Mitochondrial carrier protein

  2. NM_001357123.1 → NP_001344052.1  mitochondrial uncoupling protein 4 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC154647, AU254602
    Conserved Domains (1) summary
    pfam00153
    Location:136 → 232
    Mito_carr; Mitochondrial carrier protein

  3. NM_028711.4 → NP_082987.1  mitochondrial uncoupling protein 4 isoform 1

    See identical proteins and their annotated locations for NP_082987.1

    Status: VALIDATED

    Source sequence(s)
    AC154647, AK043831, AU254602
    Consensus CDS
    CCDS28798.1
    UniProtKB/Swiss-Prot
    Q9D6D0
    UniProtKB/TrEMBL
    Q9CX10
    Related
    ENSMUSP00000024705.5, ENSMUST00000024705.6
    Conserved Domains (2) summary
    PTZ00169
    Location:22 → 316
    PTZ00169; ADP/ATP transporter on adenylate translocase; Provisional
    pfam00153
    Location:122 → 218
    Mito_carr; Mitochondrial carrier protein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    43948630..43978105 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030250096.1 → XP_030105956.1  mitochondrial uncoupling protein 4 isoform X10

    Conserved Domains (1) summary
    pfam00153
    Location:20 → 114
    Mito_carr; Mitochondrial carrier protein

  2. XM_030250101.2 → XP_030105961.1  mitochondrial uncoupling protein 4 isoform X12

    Conserved Domains (1) summary
    pfam00153
    Location:7 → 98
    Mito_carr; Mitochondrial carrier protein

  3. XM_030250100.1 → XP_030105960.1  mitochondrial uncoupling protein 4 isoform X12

    Conserved Domains (1) summary
    pfam00153
    Location:7 → 98
    Mito_carr; Mitochondrial carrier protein

  4. XM_030250091.2 → XP_030105951.1  mitochondrial uncoupling protein 4 isoform X6

    Conserved Domains (1) summary
    pfam00153
    Location:77 → 171
    Mito_carr; Mitochondrial carrier protein

  5. XM_017317679.3 → XP_017173168.1  mitochondrial uncoupling protein 4 isoform X2

    Conserved Domains (1) summary
    pfam00153
    Location:138 → 232
    Mito_carr; Mitochondrial carrier protein

  6. XM_030250102.1 → XP_030105962.1  mitochondrial uncoupling protein 4 isoform X12

    Conserved Domains (1) summary
    pfam00153
    Location:7 → 98
    Mito_carr; Mitochondrial carrier protein

  7. XM_006525001.4 → XP_006525064.1  mitochondrial uncoupling protein 4 isoform X3

    UniProtKB/TrEMBL
    Q9CX10
    Conserved Domains (1) summary
    pfam00153
    Location:124 → 218
    Mito_carr; Mitochondrial carrier protein

  8. XM_017317681.3 → XP_017173170.1  mitochondrial uncoupling protein 4 isoform X5

    Conserved Domains (1) summary
    pfam00153
    Location:77 → 171
    Mito_carr; Mitochondrial carrier protein

  9. XM_030250095.2 → XP_030105955.1  mitochondrial uncoupling protein 4 isoform X10

    Conserved Domains (1) summary
    pfam00153
    Location:20 → 114
    Mito_carr; Mitochondrial carrier protein

  10. XM_030250103.2 → XP_030105963.1  mitochondrial uncoupling protein 4 isoform X12

    Conserved Domains (1) summary
    pfam00153
    Location:7 → 98
    Mito_carr; Mitochondrial carrier protein

  11. XM_030250099.2 → XP_030105959.1  mitochondrial uncoupling protein 4 isoform X12

    Conserved Domains (1) summary
    pfam00153
    Location:7 → 98
    Mito_carr; Mitochondrial carrier protein

  12. XM_017317678.3 → XP_017173167.1  mitochondrial uncoupling protein 4 isoform X1

    Conserved Domains (1) summary
    pfam00153
    Location:138 → 232
    Mito_carr; Mitochondrial carrier protein

  13. XM_030250092.2 → XP_030105952.1  mitochondrial uncoupling protein 4 isoform X8

    Conserved Domains (1) summary
    pfam00153
    Location:20 → 114
    Mito_carr; Mitochondrial carrier protein

  14. XM_036160809.1 → XP_036016702.1  mitochondrial uncoupling protein 4 isoform X4

    Conserved Domains (1) summary
    pfam00153
    Location:119 → 215
    Mito_carr; Mitochondrial carrier protein

  15. XM_030250098.2 → XP_030105958.1  mitochondrial uncoupling protein 4 isoform X11

    Conserved Domains (1) summary
    pfam00153
    Location:2 → 98
    Mito_carr; Mitochondrial carrier protein

  16. XM_036160814.1 → XP_036016707.1  mitochondrial uncoupling protein 4 isoform X11

    Conserved Domains (1) summary
    pfam00153
    Location:2 → 98
    Mito_carr; Mitochondrial carrier protein

  17. XM_036160812.1 → XP_036016705.1  mitochondrial uncoupling protein 4 isoform X11

    Conserved Domains (1) summary
    pfam00153
    Location:2 → 98
    Mito_carr; Mitochondrial carrier protein

  18. XM_030250094.2 → XP_030105954.1  mitochondrial uncoupling protein 4 isoform X9

    Conserved Domains (1) summary
    pfam00153
    Location:20 → 114
    Mito_carr; Mitochondrial carrier protein

  19. XM_036160813.1 → XP_036016706.1  mitochondrial uncoupling protein 4 isoform X11

    Conserved Domains (1) summary
    pfam00153
    Location:2 → 98
    Mito_carr; Mitochondrial carrier protein

  20. XM_030250093.2 → XP_030105953.1  mitochondrial uncoupling protein 4 isoform X9

    Conserved Domains (1) summary
    pfam00153
    Location:20 → 114
    Mito_carr; Mitochondrial carrier protein

  21. XM_036160811.1 → XP_036016704.1  mitochondrial uncoupling protein 4 isoform X11

    Conserved Domains (1) summary
    pfam00153
    Location:2 → 98
    Mito_carr; Mitochondrial carrier protein

  22. XM_017317682.3 → XP_017173171.1  mitochondrial uncoupling protein 4 isoform X7

    Conserved Domains (1) summary
    pfam00153
    Location:138 → 232
    Mito_carr; Mitochondrial carrier protein

RNA

  1. XR_003952195.2 RNA Sequence

  2. XR_004939591.1 RNA Sequence

  3. XR_004939590.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9D6D0.1 GenPept UniProtKB/Swiss-Prot:Q9D6D0

Gene LinkOut

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