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Otud4 OTU domain containing 4 [ Mus musculus (house mouse) ]

Gene ID: 73945, updated on 21-Apr-2024

Summary

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Official Symbol
Otud4provided by MGI
Official Full Name
OTU domain containing 4provided by MGI
Primary source
MGI:MGI:1098801
See related
Ensembl:ENSMUSG00000036990 AllianceGenome:MGI:1098801
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
D8Ertd69e; mKIAA1046; 4930431L18Rik
Summary
Enables Lys63-specific deubiquitinase activity. Involved in negative regulation of interleukin-1-mediated signaling pathway; negative regulation of toll-like receptor signaling pathway; and protein K63-linked deubiquitination. Predicted to be located in cytosol. Is expressed in several structures, including brain; cardiovascular system; genitourinary system; gut; and immune system. Orthologous to human OTUD4 (OTU deubiquitinase 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis adult (RPKM 14.9), placenta adult (RPKM 12.9) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
8 C1; 8 37.74 cM
Exon count:
22
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (80366305..80404384)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (79639676..79677755)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene 5'-nucleotidase, cytosolic II pseudogene Neighboring gene STARR-seq mESC enhancer starr_22009 Neighboring gene STARR-seq mESC enhancer starr_22010 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E3787 Neighboring gene predicted gene, 51579 Neighboring gene tumor protein D52, pseudogene Neighboring gene ATP-binding cassette, sub-family E member 1 Neighboring gene STARR-positive B cell enhancer ABC_E9318 Neighboring gene anaphase promoting complex subunit 10

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Upregulation of glycolytic enzyme PFKFB3 by deubiquitinase OTUD4 promotes cardiac fibrosis post myocardial infarction. Wang F, et al. J Mol Med (Berl), 2023 Jun. PMID 37162556, Free PMC Article
  2. OTUD4 alleviates hepatic ischemia-reperfusion injury by suppressing the K63-linked ubiquitination of TRAF6. Liu H, et al. Biochem Biophys Res Commun, 2020 Mar 19. PMID 31964525
  3. Ubiquitination and deubiquitination of 4E-T regulate neural progenitor cell maintenance and neurogenesis by controlling P-body formation. Kedia S, et al. Cell Rep, 2022 Jul 12. PMID 35830814
  4. OTUD4 Is a Phospho-Activated K63 Deubiquitinase that Regulates MyD88-Dependent Signaling. Zhao Y, et al. Mol Cell, 2018 Feb 1. PMID 29395066, Free PMC Article
  5. Loss of the tumor suppressor BAP1 causes myeloid transformation. Dey A, et al. Science, 2012 Sep 21. PMID 22878500, Free PMC Article

See all (29) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Upregulation of glycolytic enzyme PFKFB3 by deubiquitinase OTUD4 promotes cardiac fibrosis post myocardial infarction.
    Title: Upregulation of glycolytic enzyme PFKFB3 by deubiquitinase OTUD4 promotes cardiac fibrosis post myocardial infarction.
  2. OTUD4 alleviates hepatic ischemia-reperfusion injury by suppressing the K63-linked ubiquitination of TRAF6.
    Title: OTUD4 alleviates hepatic ischemia-reperfusion injury by suppressing the K63-linked ubiquitination of TRAF6.
  3. The authors show an essential role of OTUD4 in virus-triggered signaling and contribute to the understanding of deubiquitination-mediated regulation of innate antiviral responses.
    Title: Induction of OTUD4 by viral infection promotes antiviral responses through deubiquitinating and stabilizing MAVS.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 
  • Endonuclease-mediated (5)  1 citation

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables K63-linked deubiquitinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables K63-linked deubiquitinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables K63-linked deubiquitinase activity ISO
Inferred from Sequence Orthology
more info
  
enables cysteine-type deubiquitinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cysteine-type deubiquitinase activity ISO
Inferred from Sequence Orthology
more info
  
enables cysteine-type peptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables molecular adaptor activity ISO
Inferred from Sequence Orthology
more info
  
enables peptidase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in DNA alkylation repair ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within immune system process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within innate immune response IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of interleukin-1-mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of interleukin-1-mediated signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of interleukin-1-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of toll-like receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of toll-like receptor signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of toll-like receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in protein K48-linked deubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in protein K63-linked deubiquitination IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein K63-linked deubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in protein deubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within proteolysis IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of protein K48-linked deubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of protein K48-linked deubiquitination ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
OTU domain-containing protein 4
NP_001074633.1
NP_001242962.1
XP_006531469.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001081164.1 → NP_001074633.1  OTU domain-containing protein 4 isoform 2

    See identical proteins and their annotated locations for NP_001074633.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC101687
    Consensus CDS
    CCDS57626.1
    UniProtKB/TrEMBL
    A0A0R4J260
    Related
    ENSMUSP00000134097.2, ENSMUST00000173286.8
    Conserved Domains (2) summary
    pfam12293
    Location:557 → 643
    T4BSS_DotH_IcmK; Putative outer membrane core complex of type IVb secretion
    cl19932
    Location:42 → 121
    OTU; OTU-like cysteine protease

  2. NM_001256033.1 → NP_001242962.1  OTU domain-containing protein 4 isoform 1

    See identical proteins and their annotated locations for NP_001242962.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC101687, AW494258, BC138373
    Consensus CDS
    CCDS57625.1
    UniProtKB/Swiss-Prot
    B2RRE7, B7ZNI5, Q80TL3, Q9CUN2
    Related
    ENSMUSP00000133939.2, ENSMUST00000173078.8
    Conserved Domains (2) summary
    pfam12293
    Location:558 → 644
    T4BSS_DotH_IcmK; Putative outer membrane core complex of type IVb secretion
    cl19932
    Location:42 → 121
    OTU; OTU-like cysteine protease

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    80366305..80404384
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006531406.5 → XP_006531469.1  OTU domain-containing protein 4 isoform X1

    Conserved Domains (2) summary
    PHA03247
    Location:478 → 807
    PHA03247; large tegument protein UL36; Provisional
    cl19932
    Location:3 → 56
    OTU; OTU-like cysteine protease
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
B2RRE7.1 GenPept UniProtKB/Swiss-Prot:B2RRE7

Gene LinkOut

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