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Lyrm1 LYR motif containing 1 [ Mus musculus (house mouse) ]

Gene ID: 73919, updated on 5-Mar-2024

Summary

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Official Symbol
Lyrm1provided by MGI
Official Full Name
LYR motif containing 1provided by MGI
Primary source
MGI:MGI:1921169
See related
Ensembl:ENSMUSG00000030922 AllianceGenome:MGI:1921169
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
1110065L10Rik; 2310004B22Rik; 4930404J24Rik
Summary
Located in mitochondrion. Orthologous to human LYRM1 (LYR motif containing 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in testis adult (RPKM 3.1), CNS E18 (RPKM 0.8) and 16 other tissues See more
Orthologs
human all
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Genomic context

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Location:
7 F2; 7 64.31 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (119495038..119515979)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (119895713..119916756)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene acyl-CoA synthetase medium-chain family member 3 Neighboring gene exoribonuclease 2 Neighboring gene RNA exonuclease 5 Neighboring gene STARR-seq mESC enhancer starr_20039 Neighboring gene defective in cullin neddylation 1 domain containing 3 Neighboring gene STARR-positive B cell enhancer ABC_E3747 Neighboring gene STARR-seq mESC enhancer starr_20040 Neighboring gene STARR-seq mESC enhancer starr_20041 Neighboring gene dynein, axonemal, heavy chain 3 Neighboring gene predicted gene, 53369 Neighboring gene predicted gene, 25217

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Effect of LYRM1 knockdown on proliferation, apoptosis, differentiation and mitochondrial function in the P19 cell model of cardiac differentiation in vitro. Chen YM, et al. J Bioenerg Biomembr, 2016 Feb. PMID 26759027, Free PMC Article
  2. Knockdown of LYRM1 rescues insulin resistance and mitochondrial dysfunction induced by FCCP in 3T3-L1 adipocytes. Zhang M, et al. Cell Biochem Biophys, 2014 Sep. PMID 24771405
  3. Effects of Lyrm1 knockdown on mitochondrial function in 3 T3-L1 murine adipocytes. Zhu GZ, et al. J Bioenerg Biomembr, 2012 Feb. PMID 22249831
  4. Regulation of LYRM1 gene expression by free fatty acids, adipokines, and rosiglitazone in 3T3-L1 adipocytes. Zhang M, et al. Exp Diabetes Res, 2012. PMID 22110480, Free PMC Article
  5. α-Lipoic acid ameliorates impaired glucose uptake in LYRM1 overexpressing 3T3-L1 adipocytes through the IRS-1/Akt signaling pathway. Qin ZY, et al. J Bioenerg Biomembr, 2012 Oct. PMID 22820890

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. knockdown of LYRM1 induced mitochondrial impairment in P19 cells during differentiation, which was reflected by decreased ATP synthesis, lower MMP and increased ROS levels.
    Title: Effect of LYRM1 knockdown on proliferation, apoptosis, differentiation and mitochondrial function in the P19 cell model of cardiac differentiation in vitro.
  2. FCCP-induced mitochondrial dysfunction and insulin resistance are ameliorated by knockdown of LYRM1
    Title: Knockdown of LYRM1 rescues insulin resistance and mitochondrial dysfunction induced by FCCP in 3T3-L1 adipocytes.
  3. alpha-LA protects 3T3-L1 adipocytes from LYRM1-induced insulin resistance partially via its capacity to restore mitochondrial function and/or increase phosphorylation of IRS-1 and Akt.
    Title: α-Lipoic acid ameliorates impaired glucose uptake in LYRM1 overexpressing 3T3-L1 adipocytes through the IRS-1/Akt signaling pathway.
  4. Knockdown of the Lyrm1 gene in adipocytes resulted in dramatically increased cellular ATP production, mitochondrial membrane potentials and levels Ucp2 mRNA, while ROS levels were significantly decreased.
    Title: Effects of Lyrm1 knockdown on mitochondrial function in 3 T3-L1 murine adipocytes.
  5. results suggest that the expression of LYRM1 mRNA is affected by a variety of factors that are related to insulin sensitivity; LYRM1 may be an important mediator in the development of obesity-related insulin resistance
    Title: Regulation of LYRM1 gene expression by free fatty acids, adipokines, and rosiglitazone in 3T3-L1 adipocytes.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
located_in midbody ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrion HDA PubMed 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
LYR motif-containing protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001285959.1 → NP_001272888.1  LYR motif-containing protein 1

    See identical proteins and their annotated locations for NP_001272888.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3, and 4 all encode the same protein.
    Source sequence(s)
    AC131702, BU757765, BY464772, DV043140
    Consensus CDS
    CCDS21790.1
    UniProtKB/Swiss-Prot
    Q3TZE0, Q9CQB7
    Related
    ENSMUSP00000102128.2, ENSMUST00000106518.9
    Conserved Domains (1) summary
    cd20261
    Location:8 → 83
    Complex1_LYR_LYRM1; LYR (leucine-tyrosine-arginine) motif found in LYR motif-containing protein 1 (LYRM1) and similar proteins

  2. NM_001285960.1 → NP_001272889.1  LYR motif-containing protein 1

    See identical proteins and their annotated locations for NP_001272889.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3, and 4 all encode the same protein.
    Source sequence(s)
    AC131702, BU757765, BY464772, DV043140
    Consensus CDS
    CCDS21790.1
    UniProtKB/Swiss-Prot
    Q3TZE0, Q9CQB7
    Related
    ENSMUSP00000146699.2, ENSMUST00000208202.2
    Conserved Domains (1) summary
    cd20261
    Location:8 → 83
    Complex1_LYR_LYRM1; LYR (leucine-tyrosine-arginine) motif found in LYR motif-containing protein 1 (LYRM1) and similar proteins

  3. NM_001285961.2 → NP_001272890.1  LYR motif-containing protein 1

    See identical proteins and their annotated locations for NP_001272890.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3, and 4 all encode the same protein.
    Source sequence(s)
    AC131702, AK009135, AK015083, BY752674
    Consensus CDS
    CCDS21790.1
    UniProtKB/Swiss-Prot
    Q3TZE0, Q9CQB7
    Related
    ENSMUSP00000051616.4, ENSMUST00000054440.11
    Conserved Domains (1) summary
    cd20261
    Location:8 → 83
    Complex1_LYR_LYRM1; LYR (leucine-tyrosine-arginine) motif found in LYR motif-containing protein 1 (LYRM1) and similar proteins

  4. NM_029610.3 → NP_083886.1  LYR motif-containing protein 1

    See identical proteins and their annotated locations for NP_083886.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2, 3, and 4 all encode the same protein.
    Source sequence(s)
    AK009135, BY464772
    Consensus CDS
    CCDS21790.1
    UniProtKB/Swiss-Prot
    Q3TZE0, Q9CQB7
    Related
    ENSMUSP00000102127.2, ENSMUST00000106517.9
    Conserved Domains (1) summary
    cd20261
    Location:8 → 83
    Complex1_LYR_LYRM1; LYR (leucine-tyrosine-arginine) motif found in LYR motif-containing protein 1 (LYRM1) and similar proteins

RNA

  1. NR_126475.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) contains an alternate first exon and lacks an internal exon compared to variant 1. This variant is represented as non-coding because the predicted protein does not meet RefSeq quality criteria.
    Source sequence(s)
    AC131702

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    119495038..119515979
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006508239.5 → XP_006508302.1  LYR motif-containing protein 1 isoform X1

    See identical proteins and their annotated locations for XP_006508302.1

    UniProtKB/Swiss-Prot
    Q3TZE0, Q9CQB7
    Conserved Domains (1) summary
    cd20261
    Location:8 → 83
    Complex1_LYR_LYRM1; LYR (leucine-tyrosine-arginine) motif found in LYR motif-containing protein 1 (LYRM1) and similar proteins

  2. XM_006508240.4 → XP_006508303.1  LYR motif-containing protein 1 isoform X1

    See identical proteins and their annotated locations for XP_006508303.1

    UniProtKB/Swiss-Prot
    Q3TZE0, Q9CQB7
    Conserved Domains (1) summary
    cd20261
    Location:8 → 83
    Complex1_LYR_LYRM1; LYR (leucine-tyrosine-arginine) motif found in LYR motif-containing protein 1 (LYRM1) and similar proteins

  3. XM_006508237.4 → XP_006508300.1  LYR motif-containing protein 1 isoform X1

    See identical proteins and their annotated locations for XP_006508300.1

    UniProtKB/Swiss-Prot
    Q3TZE0, Q9CQB7
    Conserved Domains (1) summary
    cd20261
    Location:8 → 83
    Complex1_LYR_LYRM1; LYR (leucine-tyrosine-arginine) motif found in LYR motif-containing protein 1 (LYRM1) and similar proteins

  4. XM_006508244.4 → XP_006508307.1  LYR motif-containing protein 1 isoform X1

    See identical proteins and their annotated locations for XP_006508307.1

    UniProtKB/Swiss-Prot
    Q3TZE0, Q9CQB7
    Conserved Domains (1) summary
    cd20261
    Location:8 → 83
    Complex1_LYR_LYRM1; LYR (leucine-tyrosine-arginine) motif found in LYR motif-containing protein 1 (LYRM1) and similar proteins

  5. XM_006508243.4 → XP_006508306.1  LYR motif-containing protein 1 isoform X1

    See identical proteins and their annotated locations for XP_006508306.1

    UniProtKB/Swiss-Prot
    Q3TZE0, Q9CQB7
    Conserved Domains (1) summary
    cd20261
    Location:8 → 83
    Complex1_LYR_LYRM1; LYR (leucine-tyrosine-arginine) motif found in LYR motif-containing protein 1 (LYRM1) and similar proteins

  6. XM_006508238.4 → XP_006508301.1  LYR motif-containing protein 1 isoform X1

    See identical proteins and their annotated locations for XP_006508301.1

    UniProtKB/Swiss-Prot
    Q3TZE0, Q9CQB7
    Conserved Domains (1) summary
    cd20261
    Location:8 → 83
    Complex1_LYR_LYRM1; LYR (leucine-tyrosine-arginine) motif found in LYR motif-containing protein 1 (LYRM1) and similar proteins

  7. XM_036153480.1 → XP_036009373.1  LYR motif-containing protein 1 isoform X1

    UniProtKB/Swiss-Prot
    Q3TZE0, Q9CQB7
    Conserved Domains (1) summary
    cd20261
    Location:8 → 83
    Complex1_LYR_LYRM1; LYR (leucine-tyrosine-arginine) motif found in LYR motif-containing protein 1 (LYRM1) and similar proteins

  8. XM_006508241.4 → XP_006508304.1  LYR motif-containing protein 1 isoform X1

    See identical proteins and their annotated locations for XP_006508304.1

    UniProtKB/Swiss-Prot
    Q3TZE0, Q9CQB7
    Conserved Domains (1) summary
    cd20261
    Location:8 → 83
    Complex1_LYR_LYRM1; LYR (leucine-tyrosine-arginine) motif found in LYR motif-containing protein 1 (LYRM1) and similar proteins

  9. XM_006508234.5 → XP_006508297.1  LYR motif-containing protein 1 isoform X1

    See identical proteins and their annotated locations for XP_006508297.1

    UniProtKB/Swiss-Prot
    Q3TZE0, Q9CQB7
    Conserved Domains (1) summary
    cd20261
    Location:8 → 83
    Complex1_LYR_LYRM1; LYR (leucine-tyrosine-arginine) motif found in LYR motif-containing protein 1 (LYRM1) and similar proteins

  10. XM_006508235.5 → XP_006508298.1  LYR motif-containing protein 1 isoform X1

    See identical proteins and their annotated locations for XP_006508298.1

    UniProtKB/Swiss-Prot
    Q3TZE0, Q9CQB7
    Conserved Domains (1) summary
    cd20261
    Location:8 → 83
    Complex1_LYR_LYRM1; LYR (leucine-tyrosine-arginine) motif found in LYR motif-containing protein 1 (LYRM1) and similar proteins

  11. XM_006508236.5 → XP_006508299.1  LYR motif-containing protein 1 isoform X1

    See identical proteins and their annotated locations for XP_006508299.1

    UniProtKB/Swiss-Prot
    Q3TZE0, Q9CQB7
    Conserved Domains (1) summary
    cd20261
    Location:8 → 83
    Complex1_LYR_LYRM1; LYR (leucine-tyrosine-arginine) motif found in LYR motif-containing protein 1 (LYRM1) and similar proteins

  12. XM_036153479.1 → XP_036009372.1  LYR motif-containing protein 1 isoform X1

    UniProtKB/Swiss-Prot
    Q3TZE0, Q9CQB7
    Conserved Domains (1) summary
    cd20261
    Location:8 → 83
    Complex1_LYR_LYRM1; LYR (leucine-tyrosine-arginine) motif found in LYR motif-containing protein 1 (LYRM1) and similar proteins

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NR_104377.1: Suppressed sequence

    Description
    NR_104377.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9CQB7.1 GenPept UniProtKB/Swiss-Prot:Q9CQB7

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