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Fam110a family with sequence similarity 110, member A [ Mus musculus (house mouse) ]

Gene ID: 73847, updated on 3-Apr-2024

Summary

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Official Symbol
Fam110aprovided by MGI
Official Full Name
family with sequence similarity 110, member Aprovided by MGI
Primary source
MGI:MGI:1921097
See related
Ensembl:ENSMUSG00000027459 AllianceGenome:MGI:1921097
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
1700008J10Rik; 5430432M24Rik
Summary
Predicted to be located in cytoplasm and cytoskeleton. Is expressed in midbrain mantle layer and telencephalon mantle layer. Orthologous to human FAM110A (family with sequence similarity 110 member A). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in testis adult (RPKM 42.7), lung adult (RPKM 10.9) and 20 other tissues See more
Orthologs
human all
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Genomic context

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Location:
2 G3; 2 74.83 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (151811318..151822096, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (151969396..151980219, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene predicted gene 14154 Neighboring gene microRNA 1953 Neighboring gene STARR-seq mESC enhancer starr_06034 Neighboring gene STARR-positive B cell enhancer ABC_E6000 Neighboring gene solute carrier protein family 52, member 3 Neighboring gene STARR-seq mESC enhancer starr_06039 Neighboring gene STARR-positive B cell enhancer ABC_E11171 Neighboring gene STARR-seq mESC enhancer starr_06041 Neighboring gene expressed sequence AA387200

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. CK1-mediated phosphorylation of FAM110A promotes its interaction with mitotic spindle and controls chromosomal alignment. Aquino Perez C, et al. EMBO Rep, 2021 Jul 5. PMID 34080749, Free PMC Article
  2. Characterization of the FAM110 gene family. Hauge H, et al. Genomics, 2007 Jul. PMID 17499476
  3. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
  4. A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. Hansen J, et al. Proc Natl Acad Sci U S A, 2003 Aug 19. PMID 12904583, Free PMC Article
  5. BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. Magdaleno S, et al. PLoS Biol, 2006 Apr. PMID 16602821, Free PMC Article

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

General gene information

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Markers

Homology

Clone Names

  • MGC30344

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in mitotic spindle organization ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cell cortex IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cellular_component ND
No biological Data available
more info
  
located_in centrosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in centrosome ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in spindle microtubule IDA
Inferred from Direct Assay
more info
 PubMed 
located_in spindle microtubule ISO
Inferred from Sequence Orthology
more info
  
located_in spindle pole IDA
Inferred from Direct Assay
more info
 PubMed 
located_in spindle pole ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
protein FAM110A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001289150.2 → NP_001276079.1  protein FAM110A

    See identical proteins and their annotated locations for NP_001276079.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1. All five variants encode the same protein.
    Source sequence(s)
    AL845161
    Consensus CDS
    CCDS16875.1
    UniProtKB/Swiss-Prot
    Q505P3, Q8BQE5, Q8K024, Q8R184, Q8VEM7, Q9CU80
    UniProtKB/TrEMBL
    G4XVC4
    Related
    ENSMUSP00000105490.2, ENSMUST00000109864.8
    Conserved Domains (2) summary
    pfam14160
    Location:183 → 288
    FAM110_C; Centrosome-associated C-terminus
    pfam14161
    Location:8 → 104
    FAM110_N; Centrosome-associated N-terminus

  2. NM_001289151.2 → NP_001276080.1  protein FAM110A

    See identical proteins and their annotated locations for NP_001276080.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR, compared to variant 1. All five variants encode the same protein.
    Source sequence(s)
    AL845161
    Consensus CDS
    CCDS16875.1
    UniProtKB/Swiss-Prot
    Q505P3, Q8BQE5, Q8K024, Q8R184, Q8VEM7, Q9CU80
    UniProtKB/TrEMBL
    G4XVC4
    Related
    ENSMUSP00000105489.2, ENSMUST00000109863.2
    Conserved Domains (2) summary
    pfam14160
    Location:183 → 288
    FAM110_C; Centrosome-associated C-terminus
    pfam14161
    Location:8 → 104
    FAM110_N; Centrosome-associated N-terminus

  3. NM_001406401.1 → NP_001393330.1  protein FAM110A

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR, compared to variant 1. All five variants encode the same protein.
    Source sequence(s)
    AL845161
    UniProtKB/Swiss-Prot
    Q505P3, Q8BQE5, Q8K024, Q8R184, Q8VEM7, Q9CU80

  4. NM_028666.4 → NP_082942.2  protein FAM110A

    See identical proteins and their annotated locations for NP_082942.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. All five variants encode the same protein.
    Source sequence(s)
    AL845161
    Consensus CDS
    CCDS16875.1
    UniProtKB/Swiss-Prot
    Q505P3, Q8BQE5, Q8K024, Q8R184, Q8VEM7, Q9CU80
    UniProtKB/TrEMBL
    G4XVC4
    Related
    ENSMUSP00000105491.2, ENSMUST00000109865.8
    Conserved Domains (2) summary
    pfam14160
    Location:183 → 288
    FAM110_C; Centrosome-associated C-terminus
    pfam14161
    Location:8 → 104
    FAM110_N; Centrosome-associated N-terminus

  5. NM_146127.4 → NP_666239.1  protein FAM110A

    See identical proteins and their annotated locations for NP_666239.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. All five variants encode the same protein.
    Source sequence(s)
    AL845161
    Consensus CDS
    CCDS16875.1
    UniProtKB/Swiss-Prot
    Q505P3, Q8BQE5, Q8K024, Q8R184, Q8VEM7, Q9CU80
    UniProtKB/TrEMBL
    G4XVC4
    Related
    ENSMUSP00000053266.6, ENSMUST00000062047.6
    Conserved Domains (2) summary
    pfam14160
    Location:183 → 288
    FAM110_C; Centrosome-associated C-terminus
    pfam14161
    Location:8 → 104
    FAM110_N; Centrosome-associated N-terminus

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    151811318..151822096 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006500266.5 → XP_006500329.1  protein FAM110A isoform X2

    See identical proteins and their annotated locations for XP_006500329.1

    UniProtKB/Swiss-Prot
    Q505P3, Q8BQE5, Q8K024, Q8R184, Q8VEM7, Q9CU80
    UniProtKB/TrEMBL
    G4XVC4
    Conserved Domains (2) summary
    pfam14160
    Location:183 → 288
    FAM110_C; Centrosome-associated C-terminus
    pfam14161
    Location:8 → 104
    FAM110_N; Centrosome-associated N-terminus
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8R184.2 GenPept UniProtKB/Swiss-Prot:Q8R184

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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