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Eif3k eukaryotic translation initiation factor 3, subunit K [ Mus musculus (house mouse) ]

Gene ID: 73830, updated on 5-Mar-2024

Summary

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Official Symbol
Eif3kprovided by MGI
Official Full Name
eukaryotic translation initiation factor 3, subunit Kprovided by MGI
Primary source
MGI:MGI:1921080
See related
Ensembl:ENSMUSG00000053565 AllianceGenome:MGI:1921080
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Eif3s12; 1200009C21Rik
Summary
Contributes to translation initiation factor activity. Involved in translational initiation. Part of eukaryotic translation initiation factor 3 complex. Orthologous to human EIF3K (eukaryotic translation initiation factor 3 subunit K). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in liver E14.5 (RPKM 97.7), placenta adult (RPKM 93.2) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
7 B1; 7 16.94 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (28670797..28681322, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (28971372..28981890, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene actinin alpha 4 Neighboring gene STARR-seq mESC enhancer starr_18446 Neighboring gene predicted gene, 38978 Neighboring gene predicted gene, 51446 Neighboring gene STARR-seq mESC enhancer starr_18451 Neighboring gene STARR-positive B cell enhancer ABC_E698 Neighboring gene STARR-positive B cell enhancer ABC_E1729 Neighboring gene mitogen-activated protein kinase kinase kinase kinase 1 Neighboring gene ryanodine receptor 1, skeletal muscle Neighboring gene predicted gene, 38979

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Crystal structure of human eIF3k, the first structure of eIF3 subunits. Wei Z, et al. J Biol Chem, 2004 Aug 13. PMID 15180986
  2. eIF3k regulates apoptosis in epithelial cells by releasing caspase 3 from keratin-containing inclusions. Lin YM, et al. J Cell Sci, 2008 Jul 15. PMID 18577580
  3. Controlling tissue patterning by translational regulation of signaling transcripts through the core translation factor eIF3c. Fujii K, et al. Dev Cell, 2021 Nov 8. PMID 34752747, Free PMC Article
  4. Reconstitution reveals the functional core of mammalian eIF3. Masutani M, et al. EMBO J, 2007 Jul 25. PMID 17581632, Free PMC Article
  5. Systematic identification of factors for provirus silencing in embryonic stem cells. Yang BX, et al. Cell, 2015 Sep 24. PMID 26365490, Free PMC Article

See all (29) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA binding RCA
inferred from Reviewed Computational Analysis
more info
 PubMed 
enables ribosome binding IEA
Inferred from Electronic Annotation
more info
  
contributes_to translation initiation factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
contributes_to translation initiation factor activity IDA
Inferred from Direct Assay
more info
 PubMed 
contributes_to translation initiation factor activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in regulation of translational initiation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within translation IEA
Inferred from Electronic Annotation
more info
  
involved_in translational initiation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in translational initiation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
part_of eukaryotic translation initiation factor 3 complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of eukaryotic translation initiation factor 3 complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of eukaryotic translation initiation factor 3 complex ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
eukaryotic translation initiation factor 3 subunit K
Names
eIF-3 p25
eukaryotic translation initiation factor 3, subunit 12

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001285942.2 → NP_001272871.1  eukaryotic translation initiation factor 3 subunit K isoform 2

    See identical proteins and their annotated locations for NP_001272871.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AC166357
    Consensus CDS
    CCDS85254.1
    UniProtKB/Swiss-Prot
    Q9DBZ5
    Related
    ENSMUSP00000146940.2, ENSMUST00000207683.2
    Conserved Domains (1) summary
    pfam10075
    Location:28 → 156
    CSN8_PSD8_EIF3K; CSN8/PSMD8/EIF3K family

  2. NM_001285943.2 → NP_001272872.1  eukaryotic translation initiation factor 3 subunit K isoform 3

    See identical proteins and their annotated locations for NP_001272872.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an alternate in-frame exon and differs in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (3) lacks an alternate internal segment and has a longer and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AC166357
    Consensus CDS
    CCDS85255.1
    UniProtKB/TrEMBL
    Q3TY56
    Related
    ENSMUSP00000147214.2, ENSMUST00000208616.2
    Conserved Domains (1) summary
    pfam10075
    Location:28 → 156
    CSN8_PSD8_EIF3K; CSN8/PSMD8/EIF3K family

  3. NM_028659.4 → NP_082935.1  eukaryotic translation initiation factor 3 subunit K isoform 1

    See identical proteins and their annotated locations for NP_082935.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AC166357
    Consensus CDS
    CCDS21062.1
    UniProtKB/Swiss-Prot
    Q58EU9, Q8K3A1, Q9DBZ5
    Related
    ENSMUSP00000066038.6, ENSMUST00000066070.7
    Conserved Domains (1) summary
    pfam10075
    Location:61 → 189
    CSN8_PSD8_EIF3K; CSN8/PSMD8/EIF3K family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    28670797..28681322 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006540392.5 → XP_006540455.1  eukaryotic translation initiation factor 3 subunit K isoform X1

    Conserved Domains (1) summary
    cl24019
    Location:1 → 102
    CSN8_PSD8_EIF3K; CSN8/PSMD8/EIF3K family
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9DBZ5.1 GenPept UniProtKB/Swiss-Prot:Q9DBZ5

Gene LinkOut

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