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Ppp1r21 protein phosphatase 1, regulatory subunit 21 [ Mus musculus (house mouse) ]

Gene ID: 73825, updated on 5-Mar-2024

Summary

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Official Symbol
Ppp1r21provided by MGI
Official Full Name
protein phosphatase 1, regulatory subunit 21provided by MGI
Primary source
MGI:MGI:1921075
See related
Ensembl:ENSMUSG00000034709 AllianceGenome:MGI:1921075
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Klraq1; Ccdc128; 1110018J12Rik
Summary
Predicted to be located in endosome. Predicted to be active in early endosome. Is expressed in nervous system; neural retina; and thymus primordium. Orthologous to human PPP1R21 (protein phosphatase 1 regulatory subunit 21). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E18 (RPKM 11.8), cerebellum adult (RPKM 10.6) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
17 E4; 17 58.02 cM
Exon count:
23
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (88837552..88895795)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (88530124..88588367)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_43553 Neighboring gene predicted gene, 23947 Neighboring gene STARR-positive B cell enhancer ABC_E5644 Neighboring gene forkhead box N2 Neighboring gene STARR-seq mESC enhancer starr_43555 Neighboring gene STARR-seq mESC enhancer starr_43556 Neighboring gene predicted gene, 57646 Neighboring gene STARR-seq mESC enhancer starr_43557 Neighboring gene STARR-seq mESC enhancer starr_43559 Neighboring gene STARR-positive B cell enhancer mm9_chr17:88929251-88929552 Neighboring gene STARR-positive B cell enhancer mm9_chr17:88980789-88981089 Neighboring gene stonin 1 Neighboring gene predicted gene, 31704 Neighboring gene predicted gene, 31903 Neighboring gene predicted gene, 38460

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Isolation of novel tissue-specific genes from cDNA libraries representing the individual tissue constituents of the gastrulating mouse embryo. Harrison SM, et al. Development, 1995 Aug. PMID 7671812
  2. Mapping the NPHP-JBTS-MKS protein network reveals ciliopathy disease genes and pathways. Sang L, et al. Cell, 2011 May 13. PMID 21565611, Free PMC Article
  3. A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. Hansen J, et al. Proc Natl Acad Sci U S A, 2003 Aug 19. PMID 12904583, Free PMC Article
  4. BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. Stryke D, et al. Nucleic Acids Res, 2003 Jan 1. PMID 12520002, Free PMC Article
  5. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC117934

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
is_active_in early endosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in early endosome ISO
Inferred from Sequence Orthology
more info
  
located_in endosome IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
protein phosphatase 1 regulatory subunit 21
Names
KLRAQ motif containing 1
KLRAQ motif-containing protein 1
coiled-coil domain containing 128
coiled-coil domain-containing protein 128

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_028658.4 → NP_082934.3  protein phosphatase 1 regulatory subunit 21

    See identical proteins and their annotated locations for NP_082934.3

    Status: VALIDATED

    Source sequence(s)
    BC137673, BQ176826, BY205567
    Consensus CDS
    CCDS29023.1
    UniProtKB/Swiss-Prot
    B2RPZ6, Q3KQN7, Q3TDD9, Q3U2U9, Q8BHS9, Q9D1A1
    Related
    ENSMUSP00000048443.7, ENSMUST00000038551.8
    Conserved Domains (2) summary
    pfam10205
    Location:11 → 111
    KLRAQ; Predicted coiled-coil domain-containing protein
    pfam10212
    Location:255 → 771
    TTKRSYEDQ; Predicted coiled-coil domain-containing protein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    88837552..88895795
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017317677.1 → XP_017173166.1  protein phosphatase 1 regulatory subunit 21 isoform X1

    Conserved Domains (1) summary
    pfam10212
    Location:135 → 423
    TTKRSYEDQ; Predicted coiled-coil domain-containing protein
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q3TDD9.2 GenPept UniProtKB/Swiss-Prot:Q3TDD9

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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