U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Man2c1 mannosidase, alpha, class 2C, member 1 [ Mus musculus (house mouse) ]

Gene ID: 73744, updated on 5-Mar-2024

Summary

Go to the top of the page Help
Official Symbol
Man2c1provided by MGI
Official Full Name
mannosidase, alpha, class 2C, member 1provided by MGI
Primary source
MGI:MGI:1920994
See related
Ensembl:ENSMUSG00000032295 AllianceGenome:MGI:1920994
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
1110025H24Rik
Summary
Predicted to enable alpha-mannosidase activity. Predicted to be involved in oligosaccharide catabolic process. Predicted to be located in nucleoplasm. Orthologous to human MAN2C1 (mannosidase alpha class 2C member 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in adrenal adult (RPKM 30.4), ovary adult (RPKM 29.2) and 28 other tissues See more
Orthologs
human all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
9 B; 9 30.89 cM
Exon count:
28
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (57037953..57049497)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (57130675..57142213)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene protein tyrosine phosphatase, non-receptor type 9 Neighboring gene predicted gene 10658 Neighboring gene STARR-positive B cell enhancer ABC_E5069 Neighboring gene STARR-seq mESC enhancer starr_24217 Neighboring gene RIKEN cDNA 2700012I20 gene Neighboring gene STARR-positive B cell enhancer ABC_E9329 Neighboring gene STARR-positive B cell enhancer ABC_E711 Neighboring gene transcriptional regulator, SIN3A (yeast) Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:56978348-56978531 Neighboring gene STARR-positive B cell enhancer ABC_E3832 Neighboring gene mannosidase, alpha, class 2C, member 1, opposite strand Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:56995851-56996034 Neighboring gene STARR-positive B cell enhancer ABC_E5070 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:57006119-57006228 Neighboring gene nei endonuclease VIII-like 1 (E. coli) Neighboring gene COMM domain containing 4

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Accumulation of free oligosaccharides and tissue damage in cytosolic α-mannosidase (Man2c1)-deficient mice. Paciotti S, et al. J Biol Chem, 2014 Apr 4. PMID 24550399, Free PMC Article
  2. Cloning and expression of mouse cytosolic alpha-mannosidase (Man2c1). Costanzi E, et al. Biochim Biophys Acta, 2006 Oct. PMID 16904268
  3. A locus on mouse Chromosome 9 (Adip5) affects the relative weight of the gonadal but not retroperitoneal adipose depot. McDaniel AH, et al. Mamm Genome, 2006 Nov. PMID 17103052, Free PMC Article
  4. LCP1 preferentially binds clasped αMβ2 integrin and attenuates leukocyte adhesion under flow. Tseng HY, et al. J Cell Sci, 2018 Nov 21. PMID 30333137, Free PMC Article
  5. Widespread and dynamic translational control of red blood cell development. Alvarez-Dominguez JR, et al. Blood, 2017 Feb 2. PMID 27899360, Free PMC Article

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables alpha-mannosidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables alpha-mannosidase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables alpha-mannosidase activity ISO
Inferred from Sequence Orthology
more info
  
enables carbohydrate binding IEA
Inferred from Electronic Annotation
more info
  
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity, acting on glycosyl bonds IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in carbohydrate metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in mannose metabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in oligosaccharide catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in oligosaccharide catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

Go to the top of the page Help
Preferred Names
alpha-mannosidase 2C1
Names
alpha-D-mannoside mannohydrolase
cytosolic alpha-D-mannosidase
neutral/cytosolic alpha-mannosidase
NP_082912.1
XP_006511557.1
XP_006511562.1
XP_017169108.1
XP_030100511.1
XP_030100512.1
XP_030100514.1
XP_030100515.1
XP_030100517.1
XP_036011231.1
XP_036011232.1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_028636.2 → NP_082912.1  alpha-mannosidase 2C1

    See identical proteins and their annotated locations for NP_082912.1

    Status: PROVISIONAL

    Source sequence(s)
    AC132406
    Consensus CDS
    CCDS40646.1
    UniProtKB/Swiss-Prot
    Q3ZCX9, Q91W89
    UniProtKB/TrEMBL
    Q8BWY6
    Related
    ENSMUSP00000125478.2, ENSMUST00000160147.8
    Conserved Domains (4) summary
    cd10813
    Location:251 → 502
    GH38N_AMII_Man2C1; N-terminal catalytic domain of mammalian cytosolic alpha-mannosidase Man2C1 and similar proteins; glycoside hydrolase family 38 (GH38)
    smart00872
    Location:517 → 595
    Alpha-mann_mid; Alpha mannosidase, middle domain
    COG0383
    Location:39 → 1034
    AMS1; Alpha-mannosidase [Carbohydrate transport and metabolism]
    pfam07748
    Location:621 → 1030
    Glyco_hydro_38C; Glycosyl hydrolases family 38 C-terminal domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    57037953..57049497
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017313619.3 → XP_017169108.1  alpha-mannosidase 2C1 isoform X2

    UniProtKB/TrEMBL
    A0A1S6GWG9
    Conserved Domains (2) summary
    cd10813
    Location:277 → 569
    GH38N_AMII_Man2C1; N-terminal catalytic domain of mammalian cytosolic alpha-mannosidase Man2C1 and similar proteins; glycoside hydrolase family 38 (GH38)
    COG0383
    Location:65 → 1066
    AMS1; Alpha-mannosidase [Carbohydrate transport and metabolism]

  2. XM_006511494.5 → XP_006511557.1  alpha-mannosidase 2C1 isoform X1

    UniProtKB/TrEMBL
    A0A1S6GWG9
    Conserved Domains (2) summary
    cd10813
    Location:277 → 569
    GH38N_AMII_Man2C1; N-terminal catalytic domain of mammalian cytosolic alpha-mannosidase Man2C1 and similar proteins; glycoside hydrolase family 38 (GH38)
    COG0383
    Location:65 → 1101
    AMS1; Alpha-mannosidase [Carbohydrate transport and metabolism]

  3. XM_006511499.5 → XP_006511562.1  alpha-mannosidase 2C1 isoform X10

    UniProtKB/TrEMBL
    A0A1S6GWG9
    Conserved Domains (2) summary
    cd10813
    Location:277 → 528
    GH38N_AMII_Man2C1; N-terminal catalytic domain of mammalian cytosolic alpha-mannosidase Man2C1 and similar proteins; glycoside hydrolase family 38 (GH38)
    COG0383
    Location:65 → 1071
    AMS1; Alpha-mannosidase [Carbohydrate transport and metabolism]

  4. XM_030244651.2 → XP_030100511.1  alpha-mannosidase 2C1 isoform X3

    UniProtKB/TrEMBL
    A0A1S6GWG9
    Conserved Domains (2) summary
    cd10813
    Location:277 → 528
    GH38N_AMII_Man2C1; N-terminal catalytic domain of mammalian cytosolic alpha-mannosidase Man2C1 and similar proteins; glycoside hydrolase family 38 (GH38)
    COG0383
    Location:65 → 1025
    AMS1; Alpha-mannosidase [Carbohydrate transport and metabolism]

  5. XM_030244655.1 → XP_030100515.1  alpha-mannosidase 2C1 isoform X8

    UniProtKB/TrEMBL
    Q8BWY6
    Conserved Domains (2) summary
    cd10813
    Location:92 → 343
    GH38N_AMII_Man2C1; N-terminal catalytic domain of mammalian cytosolic alpha-mannosidase Man2C1 and similar proteins; glycoside hydrolase family 38 (GH38)
    COG0383
    Location:93 → 875
    AMS1; Alpha-mannosidase [Carbohydrate transport and metabolism]

  6. XM_030244652.2 → XP_030100512.1  alpha-mannosidase 2C1 isoform X4

    UniProtKB/TrEMBL
    Q8BWY6
    Conserved Domains (2) summary
    cd10813
    Location:146 → 438
    GH38N_AMII_Man2C1; N-terminal catalytic domain of mammalian cytosolic alpha-mannosidase Man2C1 and similar proteins; glycoside hydrolase family 38 (GH38)
    COG0383
    Location:147 → 970
    AMS1; Alpha-mannosidase [Carbohydrate transport and metabolism]

  7. XM_030244657.2 → XP_030100517.1  alpha-mannosidase 2C1 isoform X9

    Conserved Domains (2) summary
    COG0383
    Location:21 → 792
    AMS1; Alpha-mannosidase [Carbohydrate transport and metabolism]
    cl15692
    Location:21 → 260
    CE4_SF; Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily

  8. XM_036155338.1 → XP_036011231.1  alpha-mannosidase 2C1 isoform X5

    UniProtKB/TrEMBL
    Q8BWY6
    Conserved Domains (2) summary
    cd10813
    Location:146 → 397
    GH38N_AMII_Man2C1; N-terminal catalytic domain of mammalian cytosolic alpha-mannosidase Man2C1 and similar proteins; glycoside hydrolase family 38 (GH38)
    COG0383
    Location:147 → 929
    AMS1; Alpha-mannosidase [Carbohydrate transport and metabolism]

  9. XM_036155339.1 → XP_036011232.1  alpha-mannosidase 2C1 isoform X7

    UniProtKB/TrEMBL
    Q8BWY6
    Conserved Domains (2) summary
    cd10813
    Location:146 → 397
    GH38N_AMII_Man2C1; N-terminal catalytic domain of mammalian cytosolic alpha-mannosidase Man2C1 and similar proteins; glycoside hydrolase family 38 (GH38)
    COG0383
    Location:147 → 894
    AMS1; Alpha-mannosidase [Carbohydrate transport and metabolism]

  10. XM_030244654.2 → XP_030100514.1  alpha-mannosidase 2C1 isoform X6

    UniProtKB/TrEMBL
    Q8BWY6
    Conserved Domains (2) summary
    cd10813
    Location:92 → 384
    GH38N_AMII_Man2C1; N-terminal catalytic domain of mammalian cytosolic alpha-mannosidase Man2C1 and similar proteins; glycoside hydrolase family 38 (GH38)
    COG0383
    Location:93 → 916
    AMS1; Alpha-mannosidase [Carbohydrate transport and metabolism]

RNA

  1. XR_003948025.2 RNA Sequence

  2. XR_004935579.1 RNA Sequence

  3. XR_001779028.3 RNA Sequence

  4. XR_004935580.1 RNA Sequence

  5. XR_001779038.3 RNA Sequence

  6. XR_003948034.2 RNA Sequence

  7. XR_004935581.1 RNA Sequence

  8. XR_001779027.3 RNA Sequence

  9. XR_004935582.1 RNA Sequence

  10. XR_003948031.2 RNA Sequence

  11. XR_003948030.2 RNA Sequence

  12. XR_001779034.2 RNA Sequence

  13. XR_001779033.2 RNA Sequence

  14. XR_001779035.2 RNA Sequence

    Related
    ENSMUST00000161663.8

  15. XR_001779040.2 RNA Sequence

  16. XR_003948032.2 RNA Sequence

  17. XR_003948033.2 RNA Sequence

  18. XR_004935583.1 RNA Sequence

  19. XR_001779037.2 RNA Sequence

  20. XR_001779039.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q91W89.1 GenPept UniProtKB/Swiss-Prot:Q91W89

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous