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Zfp383 zinc finger protein 383 [ Mus musculus (house mouse) ]

Gene ID: 73729, updated on 8-Feb-2024

Summary

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Official Symbol
Zfp383provided by MGI
Official Full Name
zinc finger protein 383provided by MGI
Primary source
MGI:MGI:1920979
See related
Ensembl:ENSMUSG00000099689 AllianceGenome:MGI:1920979
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
1110003H10Rik
Summary
Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II. Predicted to be located in nuclear membrane and nucleoplasm. Orthologous to human ZNF383 (zinc finger protein 383). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in whole brain E14.5 (RPKM 5.0), CNS E14 (RPKM 4.9) and 19 other tissues See more
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Genomic context

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Location:
7 B1; 7 17.26 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (29607705..29616238)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (29908280..29916813)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E10434 Neighboring gene zinc finger protein 420 Neighboring gene STARR-seq mESC enhancer starr_18494 Neighboring gene zinc finger protein 27 Neighboring gene STARR-positive B cell enhancer ABC_E9288 Neighboring gene microRNA 7668 Neighboring gene STARR-seq mESC enhancer starr_18496 Neighboring gene zinc finger protein 74 Neighboring gene RIKEN cDNA C230062I16 gene Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:30738577-30738760 Neighboring gene STARR-positive B cell enhancer ABC_E8160 Neighboring gene predicted gene, 57504 Neighboring gene macrophage migration inhibitory factor, pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. EUCOMM--the European conditional mouse mutagenesis program. Friedel RH, et al. Brief Funct Genomic Proteomic, 2007 Sep. PMID 17967808
  2. BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. Stryke D, et al. Nucleic Acids Res, 2003 Jan 1. PMID 12520002, Free PMC Article
  3. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article
  4. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
  5. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in nuclear membrane ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
zinc finger protein 383

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001243908.1 → NP_001230837.1  zinc finger protein 383

    Status: VALIDATED

    Source sequence(s)
    AC149283
    Consensus CDS
    CCDS80690.1
    UniProtKB/TrEMBL
    A0A087WRR7
    Related
    ENSMUSP00000140742.2, ENSMUST00000186475.2
    Conserved Domains (6) summary
    smart00349
    Location:27 → 87
    KRAB; krueppel associated box
    COG5048
    Location:246 → 490
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:327 → 347
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:437 → 459
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:27 → 66
    KRAB; KRAB box
    pfam13465
    Location:367 → 392
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    29607705..29616238
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011250725.2 → XP_011249027.1  zinc finger protein 383 isoform X2

    Conserved Domains (5) summary
    smart00349
    Location:12 → 72
    KRAB; krueppel associated box
    COG5048
    Location:231 → 475
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:312 → 332
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:170 → 192
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:212 → 237
    zf-H2C2_2; Zinc-finger double domain

  2. XM_006540391.1 → XP_006540454.1  zinc finger protein 383 isoform X1

    Conserved Domains (5) summary
    smart00349
    Location:35 → 95
    KRAB; krueppel associated box
    COG5048
    Location:254 → 498
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:335 → 355
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:193 → 215
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:235 → 260
    zf-H2C2_2; Zinc-finger double domain
Nucleotide Protein Strain
Heading Accession and Version

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