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Glipr1 GLI pathogenesis related 1 [ Mus musculus (house mouse) ]

Gene ID: 73690, updated on 22-Mar-2024

Summary

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Official Symbol
Glipr1provided by MGI
Official Full Name
GLI pathogenesis related 1provided by MGI
Primary source
MGI:MGI:1920940
See related
Ensembl:ENSMUSG00000056888 AllianceGenome:MGI:1920940
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
RTVP1; RTVP-1; gliPR 1; mRTVP-1; 2410114O14Rik
Summary
Predicted to be located in extracellular region and membrane. Predicted to be integral component of membrane. Predicted to be active in extracellular space. Orthologous to human GLIPR1 (GLI pathogenesis related 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in bladder adult (RPKM 18.1), placenta adult (RPKM 15.6) and 26 other tissues See more
Orthologs
human all
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Genomic context

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Location:
10 D2; 10 59.98 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (111821353..111838539, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (111985448..112002639, complement)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene S-adenosylmethionine decarboxylase, pseudogene 3 pseudogene Neighboring gene STARR-seq mESC enhancer starr_27889 Neighboring gene STARR-seq mESC enhancer starr_27890 Neighboring gene STARR-seq mESC enhancer starr_27891 Neighboring gene predicted gene, 20758 Neighboring gene STARR-seq mESC enhancer starr_27892 Neighboring gene STARR-seq mESC enhancer starr_27894 Neighboring gene STARR-positive B cell enhancer mm9_chr10:111362554-111362854 Neighboring gene STARR-positive B cell enhancer ABC_E5182 Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:111409583-111409851 Neighboring gene STARR-seq mESC enhancer starr_27895 Neighboring gene STARR-positive B cell enhancer ABC_E2340 Neighboring gene STARR-positive B cell enhancer ABC_E1813 Neighboring gene KRR1, small subunit (SSU) processome component, homolog (yeast) Neighboring gene STARR-positive B cell enhancer ABC_E3914 Neighboring gene calcyphosphine 2 pseudogene Neighboring gene GLI pathogenesis-related 1 like 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. GLIPR1 expression is reduced in multiple myeloma but is not a tumour suppressor in mice. Friend N, et al. PLoS One, 2020. PMID 31995627, Free PMC Article
  2. GLI pathogenesis-related 1 functions as a tumor-suppressor in lung cancer. Sheng X, et al. Mol Cancer, 2016 Mar 18. PMID 26988096, Free PMC Article
  3. Combined therapeutic effects of adenoviral vector-mediated GLIPR1 gene therapy and radiotherapy in prostate and bladder cancer models. Fujita T, et al. Urol Oncol, 2014 Feb. PMID 23433894, Free PMC Article
  4. Genetic variations regulate alternative splicing in the 5' untranslated regions of the mouse glioma-associated oncogene 1, Gli1. Palaniswamy R, et al. BMC Mol Biol, 2010 Apr 30. PMID 20433698, Free PMC Article
  5. GLIPR1 Protects Against Cigarette Smoke-Induced Airway Inflammation via PLAU/EGFR Signaling. Peng W, et al. Int J Chron Obstruct Pulmon Dis, 2021. PMID 34675506, Free PMC Article

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. GLIPR1 Protects Against Cigarette Smoke-Induced Airway Inflammation via PLAU/EGFR Signaling.
    Title: GLIPR1 Protects Against Cigarette Smoke-Induced Airway Inflammation via PLAU/EGFR Signaling.
  2. Collectively, this study characterizes multimeric protein complexes on the sperm surface and identifies GLIPRL1L1 as a physiologically relevant regulator of IZUMO1 function and the fertilization process.
    Title: GLIPR1L1 is an IZUMO-binding protein required for optimal fertilization in the mouse.
  3. Results find that Glipr1 expression is lost in the 5TGM1 murine multiple myeloma (MM) cell line. Its overexpression in a HMCL/5TGM1 cells did not significantly alter tumor cell growth in vitro or in vivo. These results suggest that GLIPR1 is unlikely to be a potent tumor suppressor in multiple myeloma.
    Title: GLIPR1 expression is reduced in multiple myeloma but is not a tumour suppressor in mice.
  4. This study reveals a novel pathway that PRMT5/WDR77 regulates GLIPR1 expression to control lung cancer cell growth.
    Title: GLI pathogenesis-related 1 functions as a tumor-suppressor in lung cancer.
  5. Data indicate that combining adenoviral vector-mediated GLIPR1 gene therap (AdGLIPR1) with radiotherapy may achieve additive or synergistic tumor control in selected prostate and bladder tumors.
    Title: Combined therapeutic effects of adenoviral vector-mediated GLIPR1 gene therapy and radiotherapy in prostate and bladder cancer models.
  6. The genetic variation is a key determining factor for the alternative splicing events in the Gli1 5' UTRs, which have functional implications on translational efficiency.
    Title: Genetic variations regulate alternative splicing in the 5' untranslated regions of the mouse glioma-associated oncogene 1, Gli1.
  7. Identification of a novel mouse gene, mRTVP-1, as a p53 target gene. The mRTVP-1 protein has 255 amino acids and differs from the human RTVP-1 protein by two short in-frame deletions of two and nine amino acids. (mRTVP-1)
    Title: mRTVP-1, a novel p53 target gene with proapoptotic activities.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1)  1 citation
  • Endonuclease-mediated (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
glioma pathogenesis-related protein 1
Names
GLI pathogenesis-related 1 (glioma)
related to testes-specific, vespid, and pathogenesis proteins

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_028608.3 → NP_082884.1  glioma pathogenesis-related protein 1 precursor

    See identical proteins and their annotated locations for NP_082884.1

    Status: VALIDATED

    Source sequence(s)
    BB869923, BC098231, BY540964
    Consensus CDS
    CCDS24169.1
    UniProtKB/Swiss-Prot
    Q9CWG1
    UniProtKB/TrEMBL
    Q4QQK5
    Related
    ENSMUSP00000074359.6, ENSMUST00000074805.12
    Conserved Domains (1) summary
    cd05385
    Location:32 → 167
    SCP_GLIPR-1_like; SCP_GLIPR-1_like: SCP-like extracellular protein domain, glioma pathogenesis-related protein (GLIPR)-like sub-family. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    111821353..111838539 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006514218.5 → XP_006514281.1  glioma pathogenesis-related protein 1 isoform X1

    See identical proteins and their annotated locations for XP_006514281.1

    Conserved Domains (1) summary
    cd05385
    Location:32 → 168
    CAP_GLIPR1-like; CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain of glioma pathogenesis-related protein 1 and similar proteins

  2. XM_006514217.5 → XP_006514280.1  glioma pathogenesis-related protein 1 isoform X1

    See identical proteins and their annotated locations for XP_006514280.1

    Conserved Domains (1) summary
    cd05385
    Location:32 → 168
    CAP_GLIPR1-like; CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain of glioma pathogenesis-related protein 1 and similar proteins
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9CWG1.1 GenPept UniProtKB/Swiss-Prot:Q9CWG1

Gene LinkOut

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