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Atg16l2 autophagy related 16 like 2 [ Mus musculus (house mouse) ]

Gene ID: 73683, updated on 21-Apr-2024

Summary

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Official Symbol
Atg16l2provided by MGI
Official Full Name
autophagy related 16 like 2provided by MGI
Primary source
MGI:MGI:1920933
See related
Ensembl:ENSMUSG00000047767 AllianceGenome:MGI:1920933
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
2410118P20Rik
Summary
Acts upstream of or within negative stranded viral RNA replication. Located in cytosol. Is expressed in embryo. Orthologous to human ATG16L2 (autophagy related 16 like 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in spleen adult (RPKM 5.6), thymus adult (RPKM 4.5) and 27 other tissues See more
Orthologs
human all
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Genomic context

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Location:
7 E2; 7 54.54 cM
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (100935521..100951474, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (101286325..101302267, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene FCH and double SH3 domains 2 Neighboring gene predicted gene, 50587 Neighboring gene predicted gene, 57508 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:108450776-108450959 Neighboring gene STARR-seq mESC enhancer starr_19689 Neighboring gene STARR-positive B cell enhancer ABC_E1349 Neighboring gene StAR related lipid transfer domain containing 10 Neighboring gene predicted gene 20476 Neighboring gene predicted gene, 35219 Neighboring gene ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. ATG16L2 inhibits NLRP3 inflammasome activation through promoting ATG5-12-16L1 complex assembly and autophagy. Wang D, et al. Eur J Immunol, 2022 Aug. PMID 35426127
  2. Distinct Tissue-Specific Roles for the Disease-Associated Autophagy Genes ATG16L2 and ATG16L1. Khor B, et al. J Immunol, 2019 Oct 1. PMID 31451676, Free PMC Article
  3. Loss of acinar cell IKKα triggers spontaneous pancreatitis in mice. Li N, et al. J Clin Invest, 2013 May. PMID 23563314, Free PMC Article
  4. Dissection of autophagosome formation using Apg5-deficient mouse embryonic stem cells. Mizushima N, et al. J Cell Biol, 2001 Feb 19. PMID 11266458, Free PMC Article
  5. Mouse Apg16L, a novel WD-repeat protein, targets to the autophagic isolation membrane with the Apg12-Apg5 conjugate. Mizushima N, et al. J Cell Sci, 2003 May 1. PMID 12665549

See all (25) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. ATG16L2 inhibits NLRP3 inflammasome activation through promoting ATG5-12-16L1 complex assembly and autophagy.
    Title: ATG16L2 inhibits NLRP3 inflammasome activation through promoting ATG5-12-16L1 complex assembly and autophagy.
  2. results show that ATG16L1 and ATG16L2 contribute very distinctly to autophagy and cellular ontogeny in myeloid, lymphoid, and epithelial lineages. Dysregulation of any of these lineages could contribute to complex diseases like Crohn disease and systemic lupus erythematosus.
    Title: Distinct Tissue-Specific Roles for the Disease-Associated Autophagy Genes ATG16L2 and ATG16L1.
  3. IKKalpha, which may control autophagic protein degradation through its interaction with ATG16L2, plays a critical role in maintaining pancreatic acinar cell homeostasis, whose dysregulation promotes pancreatitis through p62 aggregate accumulation
    Title: Loss of acinar cell IKKα triggers spontaneous pancreatitis in mice.
  4. Despite forming the Atg12-Atg5-Atg16L2 complex, Atg16L2 is not recruited to phagophores and is mostly present in the cytosol.
    Title: Atg16L2, a novel isoform of mammalian Atg16L that is not essential for canonical autophagy despite forming an Atg12–5-16L2 complex.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2)  1 citation
  • Chemically induced (ENU) (1) 
  • Endonuclease-mediated (3) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
NOT involved_in autophagosome assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in autophagosome assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
NOT involved_in autophagy IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in macroautophagy IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within negative stranded viral RNA replication IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within protein transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of Atg12-Atg5-Atg16 complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of Atg12-Atg5-Atg16 complex ISO
Inferred from Sequence Orthology
more info
  
NOT located_in autophagosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in phagophore assembly site membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
protein Atg16l2
Names
APG16-like 2
Atg16L2 alpha
Atg16L2 beta
autophagy-related 16-like 2 alpha
autophagy-related 16-like 2 beta
autophagy-related protein 16-2
mFLJ00012 protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001111111.1 → NP_001104581.1  protein Atg16l2

    See identical proteins and their annotated locations for NP_001104581.1

    Status: VALIDATED

    Source sequence(s)
    AK010773, BC060054, BP767155
    Consensus CDS
    CCDS52329.1
    UniProtKB/Swiss-Prot
    D3Z653, G9M4M8, Q6KAU8, Q6PAU0
    Related
    ENSMUSP00000112500.2, ENSMUST00000120267.9
    Conserved Domains (6) summary
    COG2319
    Location:327 → 622
    WD40; WD40 repeat [General function prediction only]
    cd00200
    Location:335 → 622
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    pfam08614
    Location:20 → 207
    ATG16; Autophagy protein 16 (ATG16)
    pfam16034
    Location:21 → 198
    JAKMIP_CC3; JAKMIP CC3 domain
    sd00039
    Location:345 → 382
    7WD40; WD40 repeat [structural motif]
    cl02193
    Location:109 → 196
    VirB5_like; VirB5 protein family

RNA

  1. NR_152152.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses alternate splice sites in several internal exons, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC107638
    Related
    ENSMUST00000139609.8

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    100935521..100951474 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006508225.5 → XP_006508288.1  protein Atg16l2 isoform X1

    Conserved Domains (3) summary
    cd00200
    Location:338 → 539
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:348 → 385
    7WD40; WD40 repeat [structural motif]
    pfam08614
    Location:59 → 231
    ATG16; Autophagy protein 16 (ATG16)

  2. XM_006508231.5 → XP_006508294.1  protein Atg16l2 isoform X8

    Conserved Domains (3) summary
    cd00200
    Location:359 → 560
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:369 → 406
    7WD40; WD40 repeat [structural motif]
    pfam08614
    Location:59 → 231
    ATG16; Autophagy protein 16 (ATG16)

  3. XM_006508226.5 → XP_006508289.1  protein Atg16l2 isoform X3

    See identical proteins and their annotated locations for XP_006508289.1

    Related
    ENSMUSP00000113320.2, ENSMUST00000122116.8
    Conserved Domains (3) summary
    cd00200
    Location:338 → 625
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:348 → 385
    7WD40; WD40 repeat [structural motif]
    pfam08614
    Location:59 → 231
    ATG16; Autophagy protein 16 (ATG16)

  4. XM_036153476.1 → XP_036009369.1  protein Atg16l2 isoform X5

    Conserved Domains (3) summary
    cd00200
    Location:316 → 517
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:326 → 363
    7WD40; WD40 repeat [structural motif]
    pfam08614
    Location:59 → 231
    ATG16; Autophagy protein 16 (ATG16)

  5. XM_036153475.1 → XP_036009368.1  protein Atg16l2 isoform X2

    Conserved Domains (3) summary
    cd00200
    Location:337 → 538
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:347 → 384
    7WD40; WD40 repeat [structural motif]
    pfam08614
    Location:59 → 231
    ATG16; Autophagy protein 16 (ATG16)

  6. XM_011241916.4 → XP_011240218.1  protein Atg16l2 isoform X6

    Conserved Domains (3) summary
    cd00200
    Location:359 → 560
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:369 → 406
    7WD40; WD40 repeat [structural motif]
    pfam08614
    Location:59 → 231
    ATG16; Autophagy protein 16 (ATG16)

  7. XM_006508227.5 → XP_006508290.1  protein Atg16l2 isoform X4

    Conserved Domains (3) summary
    cd00200
    Location:359 → 616
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:369 → 406
    7WD40; WD40 repeat [structural motif]
    pfam08614
    Location:59 → 231
    ATG16; Autophagy protein 16 (ATG16)

  8. XM_036153477.1 → XP_036009370.1  protein Atg16l2 isoform X9

    Conserved Domains (3) summary
    cd00200
    Location:204 → 405
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:214 → 251
    7WD40; WD40 repeat [structural motif]
    pfam08614
    Location:1 → 97
    ATG16; Autophagy protein 16 (ATG16)

  9. XM_006508228.3 → XP_006508291.1  protein Atg16l2 isoform X7

    See identical proteins and their annotated locations for XP_006508291.1

    Conserved Domains (4) summary
    COG3064
    Location:2 → 208
    TolA; Membrane protein involved in colicin uptake [Cell wall/membrane/envelope biogenesis]
    cd00200
    Location:225 → 426
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:235 → 272
    7WD40; WD40 repeat [structural motif]
    pfam08614
    Location:1 → 97
    ATG16; Autophagy protein 16 (ATG16)

  10. XM_030243023.2 → XP_030098883.1  protein Atg16l2 isoform X9

    Conserved Domains (3) summary
    cd00200
    Location:204 → 405
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:214 → 251
    7WD40; WD40 repeat [structural motif]
    pfam08614
    Location:1 → 97
    ATG16; Autophagy protein 16 (ATG16)

  11. XM_011241918.3 → XP_011240220.1  protein Atg16l2 isoform X7

    See identical proteins and their annotated locations for XP_011240220.1

    Conserved Domains (4) summary
    COG3064
    Location:2 → 208
    TolA; Membrane protein involved in colicin uptake [Cell wall/membrane/envelope biogenesis]
    cd00200
    Location:225 → 426
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:235 → 272
    7WD40; WD40 repeat [structural motif]
    pfam08614
    Location:1 → 97
    ATG16; Autophagy protein 16 (ATG16)

  12. XM_030243022.2 → XP_030098882.1  protein Atg16l2 isoform X7

    Conserved Domains (4) summary
    COG3064
    Location:2 → 208
    TolA; Membrane protein involved in colicin uptake [Cell wall/membrane/envelope biogenesis]
    cd00200
    Location:225 → 426
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:235 → 272
    7WD40; WD40 repeat [structural motif]
    pfam08614
    Location:1 → 97
    ATG16; Autophagy protein 16 (ATG16)

  13. XM_006508230.3 → XP_006508293.1  protein Atg16l2 isoform X7

    See identical proteins and their annotated locations for XP_006508293.1

    Conserved Domains (4) summary
    COG3064
    Location:2 → 208
    TolA; Membrane protein involved in colicin uptake [Cell wall/membrane/envelope biogenesis]
    cd00200
    Location:225 → 426
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:235 → 272
    7WD40; WD40 repeat [structural motif]
    pfam08614
    Location:1 → 97
    ATG16; Autophagy protein 16 (ATG16)

RNA

  1. XR_003946569.2 RNA Sequence

  2. XR_003946571.2 RNA Sequence

  3. XR_004934191.1 RNA Sequence

  4. XR_378274.5 RNA Sequence

  5. XR_004934190.1 RNA Sequence

  6. XR_001778004.3 RNA Sequence

  7. XR_004934192.1 RNA Sequence

  8. XR_003946570.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6KAU8.2 GenPept UniProtKB/Swiss-Prot:Q6KAU8

Gene LinkOut

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