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Trmt11 tRNA methyltransferase 11 [ Mus musculus (house mouse) ]

Gene ID: 73681, updated on 21-Apr-2024

Summary

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Official Symbol
Trmt11provided by MGI
Official Full Name
tRNA methyltransferase 11provided by MGI
Primary source
MGI:MGI:1920931
See related
Ensembl:ENSMUSG00000019792 AllianceGenome:MGI:1920931
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
2410075D05Rik; 3110045I18Rik
Summary
Predicted to enable tRNA (guanine-N2-)-methyltransferase activity. Predicted to be involved in methylation. Predicted to act upstream of or within tRNA processing. Predicted to be active in cytoplasm. Is expressed in submandibular gland primordium. Orthologous to human TRMT11 (tRNA methyltransferase 11 homolog). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in liver E14 (RPKM 1.8), CNS E11.5 (RPKM 1.6) and 23 other tissues See more
Orthologs
human all
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Genomic context

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Location:
10 A4; 10 17.07 cM
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (30410218..30477598, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (30534225..30602149, complement)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 40622 Neighboring gene predicted gene, 22623 Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:30320514-30320623 Neighboring gene STARR-positive B cell enhancer ABC_E6828 Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:30338273-30338456 Neighboring gene STARR-seq mESC enhancer starr_26197 Neighboring gene predicted gene, 20300 Neighboring gene histidine triad nucleotide binding protein 3 Neighboring gene STARR-seq mESC enhancer starr_26199 Neighboring gene nuclear receptor coactivator 7 Neighboring gene STARR-seq mESC enhancer starr_26200 Neighboring gene STARR-positive B cell enhancer ABC_E5123 Neighboring gene STARR-seq mESC enhancer starr_26202 Neighboring gene non-POU-domain-containing, octamer binding protein pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Pourhaghighi R, et al. Cell Syst, 2020 Apr 22. PMID 32325033, Free PMC Article
  2. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article
  3. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548
  4. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article
  5. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 
  • Endonuclease-mediated (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables methyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
enables tRNA binding IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within methylation IEA
Inferred from Electronic Annotation
more info
  
involved_in methylation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within tRNA processing IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
tRNA (guanine(10)-N2)-methyltransferase homolog
Names
tRNA guanosine-2'-O-methyltransferase TRM11 homolog
tRNA methyltransferase 11 homolog
NP_001345735.1
NP_082880.2
XP_006512940.1
XP_006512943.1
XP_030101177.1
XP_030101179.1
XP_030101180.1
XP_036011940.1
XP_036011941.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001358806.1 → NP_001345735.1  tRNA (guanine(10)-N2)-methyltransferase homolog isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC153899, AK010722, AK032943, BG083636, BY259542
    Conserved Domains (1) summary
    COG1041
    Location:2 → 173
    Trm11; tRNA G10 N-methylase Trm11 [Translation, ribosomal structure and biogenesis]

  2. NM_028604.3 → NP_082880.2  tRNA (guanine(10)-N2)-methyltransferase homolog isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC153899, AK010722, AK032943, BG083636, BY259542
    Consensus CDS
    CCDS23763.1
    UniProtKB/Swiss-Prot
    Q80Y71, Q9CWH5
    UniProtKB/TrEMBL
    E9QKG3
    Related
    ENSMUSP00000019927.7, ENSMUST00000019927.7
    Conserved Domains (2) summary
    COG1041
    Location:9 → 398
    Trm11; tRNA G10 N-methylase Trm11 [Translation, ribosomal structure and biogenesis]
    cl17173
    Location:190 → 321
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    30410218..30477598 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006512877.4 → XP_006512940.1  tRNA (guanine(10)-N2)-methyltransferase homolog isoform X1

    UniProtKB/Swiss-Prot
    Q80Y71, Q9CWH5
    Conserved Domains (1) summary
    COG1041
    Location:9 → 346
    Trm11; tRNA G10 N-methylase Trm11 [Translation, ribosomal structure and biogenesis]

  2. XM_030245319.2 → XP_030101179.1  tRNA (guanine(10)-N2)-methyltransferase homolog isoform X5

    Conserved Domains (1) summary
    COG1041
    Location:2 → 173
    Trm11; tRNA G10 N-methylase Trm11 [Translation, ribosomal structure and biogenesis]

  3. XM_006512880.5 → XP_006512943.1  tRNA (guanine(10)-N2)-methyltransferase homolog isoform X4

    Conserved Domains (1) summary
    COG1041
    Location:1 → 200
    Trm11; tRNA G10 N-methylase Trm11 [Translation, ribosomal structure and biogenesis]

  4. XM_030245317.2 → XP_030101177.1  tRNA (guanine(10)-N2)-methyltransferase homolog isoform X3

    UniProtKB/Swiss-Prot
    Q80Y71, Q9CWH5
    Conserved Domains (1) summary
    COG1041
    Location:5 → 330
    Trm11; tRNA G10 N-methylase Trm11 [Translation, ribosomal structure and biogenesis]

  5. XM_030245320.2 → XP_030101180.1  tRNA (guanine(10)-N2)-methyltransferase homolog isoform X5

    Conserved Domains (1) summary
    COG1041
    Location:2 → 173
    Trm11; tRNA G10 N-methylase Trm11 [Translation, ribosomal structure and biogenesis]

  6. XM_036156047.1 → XP_036011940.1  tRNA (guanine(10)-N2)-methyltransferase homolog isoform X2

    UniProtKB/Swiss-Prot
    Q80Y71, Q9CWH5
    Conserved Domains (1) summary
    COG1041
    Location:7 → 335
    Trm11; tRNA G10 N-methylase Trm11 [Translation, ribosomal structure and biogenesis]

  7. XM_036156048.1 → XP_036011941.1  tRNA (guanine(10)-N2)-methyltransferase homolog isoform X5

    Conserved Domains (1) summary
    COG1041
    Location:2 → 173
    Trm11; tRNA G10 N-methylase Trm11 [Translation, ribosomal structure and biogenesis]
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9CWH5.1 GenPept UniProtKB/Swiss-Prot:Q9CWH5

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