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Wdr75 WD repeat domain 75 [ Mus musculus (house mouse) ]

Gene ID: 73674, updated on 5-Mar-2024

Summary

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Official Symbol
Wdr75provided by MGI
Official Full Name
WD repeat domain 75provided by MGI
Primary source
MGI:MGI:1920924
See related
Ensembl:ENSMUSG00000025995 AllianceGenome:MGI:1920924
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
1300003A18Rik; 2410118I19Rik
Summary
Predicted to be involved in positive regulation of rRNA processing and positive regulation of transcription by RNA polymerase I. Predicted to act upstream of or within rRNA processing. Predicted to be located in nucleolus. Is expressed in pancreas epithelium. Orthologous to human WDR75 (WD repeat domain 75). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 11.4), limb E14.5 (RPKM 8.6) and 26 other tissues See more
Orthologs
human all
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Genomic context

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Location:
1 C1.1; 1 23.87 cM
Exon count:
21
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (45834313..45862798)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (45795153..45823638)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_00820 Neighboring gene predicted gene, 51621 Neighboring gene predicted gene, 23974 Neighboring gene ubiquitin specific peptidase 10 pseudogene Neighboring gene STARR-positive B cell enhancer mm9_chr1:45851844-45852145 Neighboring gene STARR-positive B cell enhancer ABC_E3271 Neighboring gene predicted gene, 30900 Neighboring gene myosin, light polypeptide 6, alkali, smooth muscle and non-muscle pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. A survey of genes expressed in undifferentiated mouse embryonal carcinoma F9 cells: characterization of low-abundance mRNAs. Nishiguchi S, et al. J Biochem, 1994 Jul. PMID 7798170
  2. Twist1 transcriptional targets in the developing atrio-ventricular canal of the mouse. Vrljicak P, et al. PLoS One, 2012. PMID 22815831, Free PMC Article
  3. Cracking the egg: molecular dynamics and evolutionary aspects of the transition from the fully grown oocyte to embryo. Evsikov AV, et al. Genes Dev, 2006 Oct 1. PMID 17015433, Free PMC Article
  4. Transcription factor Foxp3 and its protein partners form a complex regulatory network. Rudra D, et al. Nat Immunol, 2012 Oct. PMID 22922362, Free PMC Article
  5. Identification of transcripts with enriched expression in the developing and adult pancreas. Hoffman BG, et al. Genome Biol, 2008. PMID 18554416, Free PMC Article

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ12545, MGC143988

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in positive regulation of rRNA processing IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of rRNA processing ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of transcription by RNA polymerase I IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of transcription by RNA polymerase I ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within rRNA processing IEA
Inferred from Electronic Annotation
more info
  
involved_in ribosomal small subunit biogenesis ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within ribosome biogenesis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in nucleolus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
part_of small-subunit processome ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
WD repeat-containing protein 75
Names
U3 small nucleolar RNA-associated protein 17 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_028599.3 → NP_082875.1  WD repeat-containing protein 75

    See identical proteins and their annotated locations for NP_082875.1

    Status: VALIDATED

    Source sequence(s)
    AK152412, AK163221, CD541304, DV648013
    Consensus CDS
    CCDS14932.1
    UniProtKB/Swiss-Prot
    Q08EC1, Q3U821
    UniProtKB/TrEMBL
    Q3TQZ0
    Related
    ENSMUSP00000027139.9, ENSMUST00000027139.15
    Conserved Domains (3) summary
    COG2319
    Location:23 → 319
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:60 → 98
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:23 → 313
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    45834313..45862798
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_004934780.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q3U821.1 GenPept UniProtKB/Swiss-Prot:Q3U821

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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