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Ms4a6c membrane-spanning 4-domains, subfamily A, member 6C [ Mus musculus (house mouse) ]

Gene ID: 73656, updated on 18-Apr-2024

Summary

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Official Symbol
Ms4a6cprovided by MGI
Official Full Name
membrane-spanning 4-domains, subfamily A, member 6Cprovided by MGI
Primary source
MGI:MGI:2385644
See related
Ensembl:ENSMUSG00000079419 AllianceGenome:MGI:2385644
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
2200009H22Rik; 2210417N07Rik
Summary
Predicted to be located in trans-Golgi network. Orthologous to several human genes including MS4A6A (membrane spanning 4-domains A6A). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in spleen adult (RPKM 3.1), mammary gland adult (RPKM 1.9) and 20 other tissues See more
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Genomic context

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Location:
19 A; 19 8.44 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (11446718..11464433)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (11469353..11487182)

Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene heat shock protein 90, alpha (cytosolic), class A member 1 pseudogene Neighboring gene membrane-spanning 4-domains, subfamily A, member 4B Neighboring gene expressed sequence BE692007 Neighboring gene STARR-positive B cell enhancer ABC_E7634 Neighboring gene STARR-positive B cell enhancer ABC_E4266 Neighboring gene STARR-positive B cell enhancer ABC_E11672 Neighboring gene STARR-positive B cell enhancer ABC_E8739 Neighboring gene predicted gene 8369 Neighboring gene membrane-spanning 4-domains, subfamily A, member 6B

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Identification of a CD20-, FcepsilonRIbeta-, and HTm4-related gene family: sixteen new MS4A family members expressed in human and mouse. Liang Y, et al. Genomics, 2001 Mar 1. PMID 11401424
  2. A mouse knockout library for secreted and transmembrane proteins. Tang T, et al. Nat Biotechnol, 2010 Jul. PMID 20562862
  3. GUDMAP: the genitourinary developmental molecular anatomy project. McMahon AP, et al. J Am Soc Nephrol, 2008 Apr. PMID 18287559
  4. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548
  5. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (1)  1 citation

General gene information

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Homology

Gene Ontology Provided by MGI

Process Evidence Code Pubs
involved_in cell surface receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in trans-Golgi network IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in trans-Golgi network ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
membrane-spanning 4-domains subfamily A member 6C

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001166376.1 → NP_001159848.1  membrane-spanning 4-domains subfamily A member 6C isoform 2

    See identical proteins and their annotated locations for NP_001159848.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) has multiple differences in the presence and absence of exons at its 3' end, compared to variant 1. These differences produce a unique 3' coding region and 3' UTR, compared to variant 1. The encoded protein (isoform 2) is shorter than isoform 1.
    Source sequence(s)
    BC062247, BY164174
    UniProtKB/TrEMBL
    Q6P6F8
    Related
    ENSMUST00000187462.2
    Conserved Domains (1) summary
    pfam04103
    Location:47 → 95
    CD20; CD20-like family

  2. NM_028595.4 → NP_082871.2  membrane-spanning 4-domains subfamily A member 6C isoform 1

    See identical proteins and their annotated locations for NP_082871.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AK150397, AK152258, BY164174, BY691481
    Consensus CDS
    CCDS50395.1
    UniProtKB/Swiss-Prot
    Q3U8E1, Q8BVZ4, Q99N08, Q9D7Z9
    Related
    ENSMUSP00000132425.2, ENSMUST00000165310.3
    Conserved Domains (1) summary
    pfam04103
    Location:47 → 207
    CD20; CD20-like family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000085.7 Reference GRCm39 C57BL/6J

    Range
    11446718..11464433
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006527381.5 → XP_006527444.1  membrane-spanning 4-domains subfamily A member 6C isoform X1

    Conserved Domains (1) summary
    pfam04103
    Location:50 → 207
    CD20; CD20-like family

RNA

  1. XR_877690.3 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q99N08.1 GenPept UniProtKB/Swiss-Prot:Q99N08

Gene LinkOut

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