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Marveld3 MARVEL (membrane-associating) domain containing 3 [ Mus musculus (house mouse) ]

Gene ID: 73608, updated on 5-Mar-2024

Summary

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Official Symbol
Marveld3provided by MGI
Official Full Name
MARVEL (membrane-associating) domain containing 3provided by MGI
Primary source
MGI:MGI:1920858
See related
Ensembl:ENSMUSG00000001672 AllianceGenome:MGI:1920858
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Marvd3; Mrvldc3; 1810006A16Rik
Summary
Predicted to enable mitogen-activated protein kinase kinase kinase binding activity. Acts upstream of or within cell-cell junction organization; negative regulation of epithelial cell migration; and negative regulation of epithelial cell proliferation. Located in bicellular tight junction. Is expressed in brain ventricle and choroid plexus; foregut; renal calyx; retina; and trachea. Orthologous to human MARVELD3 (MARVEL domain containing 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in colon adult (RPKM 9.8), large intestine adult (RPKM 7.0) and 9 other tissues See more
Orthologs
human all
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Genomic context

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Location:
8 D3; 8 57.38 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (110674541..110688837, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (109947909..109962205, complement)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene adaptor protein complex AP-1, gamma 1 subunit Neighboring gene predicted gene, 17344 Neighboring gene predicted gene, 25321 Neighboring gene PH domain and leucine rich repeat protein phosphatase 2 Neighboring gene STARR-seq mESC enhancer starr_22662 Neighboring gene STARR-positive B cell enhancer ABC_E6682 Neighboring gene STARR-positive B cell enhancer ABC_E6683 Neighboring gene STARR-positive B cell enhancer ABC_E10522 Neighboring gene STARR-positive B cell enhancer ABC_E8263 Neighboring gene STARR-seq mESC enhancer starr_22664 Neighboring gene 40S ribosomal protein S24 pseudogene Neighboring gene RIKEN cDNA 1700064F23 gene Neighboring gene STARR-seq mESC enhancer starr_22666 Neighboring gene tyrosine aminotransferase

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. MarvelD3 Is Upregulated in Ulcerative Colitis and Has Attenuating Effects during Colitis Indirectly Stabilizing the Intestinal Barrier. Weiß F, et al. Cells, 2022 May 4. PMID 35563847, Free PMC Article
  2. MarvelD3 couples tight junctions to the MEKK1-JNK pathway to regulate cell behavior and survival. Steed E, et al. J Cell Biol, 2014 Mar 3. PMID 24567356, Free PMC Article
  3. Tight junction-associated MARVEL proteins marveld3, tricellulin, and occludin have distinct but overlapping functions. Raleigh DR, et al. Mol Biol Cell, 2010 Apr 1. PMID 20164257, Free PMC Article
  4. Spatio-temporal expression pattern and role of the tight junction protein MarvelD3 in pancreas development and function. Heymans C, et al. Sci Rep, 2021 Jul 15. PMID 34267243, Free PMC Article
  5. Inactivation of the microRNA-183/96/182 cluster results in syndromic retinal degeneration. Lumayag S, et al. Proc Natl Acad Sci U S A, 2013 Feb 5. PMID 23341629, Free PMC Article

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. MarvelD3 Is Upregulated in Ulcerative Colitis and Has Attenuating Effects during Colitis Indirectly Stabilizing the Intestinal Barrier.
    Title: MarvelD3 Is Upregulated in Ulcerative Colitis and Has Attenuating Effects during Colitis Indirectly Stabilizing the Intestinal Barrier.
  2. Spatio-temporal expression pattern and role of the tight junction protein MarvelD3 in pancreas development and function.
    Title: Spatio-temporal expression pattern and role of the tight junction protein MarvelD3 in pancreas development and function.
  3. marvelD3, occludin, and tricellulin define the tight junction-associated MARVEL protein family
    Title: Tight junction-associated MARVEL proteins marveld3, tricellulin, and occludin have distinct but overlapping functions.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables mitogen-activated protein kinase kinase kinase binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in bicellular tight junction assembly ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within cell-cell junction organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within cell-cell junction organization ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within negative regulation of JNK cascade ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within negative regulation of epithelial cell migration IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within negative regulation of epithelial cell migration ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within negative regulation of epithelial cell proliferation IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within negative regulation of epithelial cell proliferation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within protein localization to cell junction ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within response to osmotic stress ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in anchoring junction IEA
Inferred from Electronic Annotation
more info
  
located_in bicellular tight junction IDA
Inferred from Direct Assay
more info
 PubMed 
located_in bicellular tight junction ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasmic vesicle ISO
Inferred from Sequence Orthology
more info
  
part_of mRNA cleavage and polyadenylation specificity factor complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
MARVEL domain-containing protein 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_028584.3 → NP_082860.2  MARVEL domain-containing protein 3 isoform a

    See identical proteins and their annotated locations for NP_082860.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the shorter isoform (a).
    Source sequence(s)
    AK007346, AV360109, AW107118, BB619320, BY088355
    Consensus CDS
    CCDS22657.1
    UniProtKB/Swiss-Prot
    Q8R109, Q9D956
    UniProtKB/TrEMBL
    G3X9A4
    Related
    ENSMUSP00000052309.7, ENSMUST00000051430.7
    Conserved Domains (2) summary
    PHA03231
    Location:341 → 374
    PHA03231; glycoprotein BALF4; Provisional
    pfam01284
    Location:232 → 355
    MARVEL; Membrane-associating domain

  2. NM_212447.2 → NP_997612.2  MARVEL domain-containing protein 3 isoform b

    See identical proteins and their annotated locations for NP_997612.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 3' coding region and 3' UTR, compared to variant 1. The resulting isoform (b) has a distinct C-terminus and is longer than isoform a.
    Source sequence(s)
    AC122807, AK007346, BB619320, BY088355
    Consensus CDS
    CCDS22656.1
    UniProtKB/TrEMBL
    G3X8Q2
    Related
    ENSMUSP00000001722.8, ENSMUST00000001722.14
    Conserved Domains (2) summary
    COG1294
    Location:196 → 305
    AppB; Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]
    TIGR01622
    Location:33 → 96
    SF-CC1; splicing factor, CC1-like family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    110674541..110688837 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9D956.1 GenPept UniProtKB/Swiss-Prot:Q9D956

Gene LinkOut

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