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Mipol1 mirror-image polydactyly 1 [ Mus musculus (house mouse) ]

Gene ID: 73490, updated on 21-Apr-2024

Summary

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Official Symbol
Mipol1provided by MGI
Official Full Name
mirror-image polydactyly 1provided by MGI
Primary source
MGI:MGI:1920740
See related
Ensembl:ENSMUSG00000047022 AllianceGenome:MGI:1920740
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
D12Ertd19e; 1700081O04Rik; 6030439O22Rik
Summary
Predicted to enable identical protein binding activity. Predicted to be located in nucleus. Is expressed in brain; genitourinary system; retina outer nuclear layer; and stomach. Orthologous to human MIPOL1 (mirror-image polydactyly 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in adrenal adult (RPKM 4.7), ovary adult (RPKM 4.1) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
12 C1; 12 24.7 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (57277211..57546809)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (57230425..57457241)

Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene solute carrier family 25 (mitochondrial oxodicarboxylate carrier), member 21 Neighboring gene STARR-seq mESC enhancer starr_32215 Neighboring gene STARR-seq mESC enhancer starr_32216 Neighboring gene predicted gene, 30001 Neighboring gene STARR-seq mESC enhancer starr_32218 Neighboring gene STARR-seq mESC enhancer starr_32219 Neighboring gene STARR-positive B cell enhancer ABC_E7135 Neighboring gene predicted gene, 40426 Neighboring gene phosphoribosyl pyrophosphate synthetase 1-like 3 Neighboring gene serum/glucocorticoid regulated kinase 1 pseudogene Neighboring gene STARR-seq mESC enhancer starr_32224 Neighboring gene predicted gene 16246 Neighboring gene STARR-seq mESC enhancer starr_32225 Neighboring gene predicted gene, 20016 Neighboring gene TAR DNA-binding protein 43 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Chromosome 14 transfer and functional studies identify a candidate tumor suppressor gene, mirror image polydactyly 1, in nasopharyngeal carcinoma. Cheung AK, et al. Proc Natl Acad Sci U S A, 2009 Aug 25. PMID 19667180, Free PMC Article
  2. A novel gene is disrupted at a 14q13 breakpoint of t(2;14) in a patient with mirror-image polydactyly of hands and feet. Kondoh S, et al. J Hum Genet, 2002. PMID 11954550
  3. Mutagenesis of diploid mammalian genes by gene entrapment. Lin Q, et al. Nucleic Acids Res, 2006. PMID 17062627, Free PMC Article
  4. Genomic analysis of mouse retinal development. Blackshaw S, et al. PLoS Biol, 2004 Sep. PMID 15226823, Free PMC Article
  5. High-throughput discovery of novel developmental phenotypes. Dickinson ME, et al. Nature, 2016 Sep 22. PMID 27626380, Free PMC Article

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 
  • Endonuclease-mediated (1) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
mirror-image polydactyly gene 1 protein homolog
Names
mirror-image polydactyly gene 1 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001164370.2 → NP_001157842.1  mirror-image polydactyly gene 1 protein homolog isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC122307, AC124486
    UniProtKB/TrEMBL
    E9PZ24, E9Q8Z7
    Related
    ENSMUSP00000121617.2, ENSMUST00000145003.8
    Conserved Domains (2) summary
    PRK02224
    Location:69 → 297
    PRK02224; chromosome segregation protein; Provisional
    COG4372
    Location:217 → 373
    COG4372; Uncharacterized conserved protein, contains DUF3084 domain [Function unknown]

  2. NM_001422492.1 → NP_001409421.1  mirror-image polydactyly gene 1 protein homolog isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC122307, AC124486
    Consensus CDS
    CCDS49070.1
    UniProtKB/TrEMBL
    G3UVV8

  3. NM_001422493.1 → NP_001409422.1  mirror-image polydactyly gene 1 protein homolog isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC122307, AC124486

  4. NM_001422494.1 → NP_001409423.1  mirror-image polydactyly gene 1 protein homolog isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC124486

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000078.7 Reference GRCm39 C57BL/6J

    Range
    57277211..57546809
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9D9F8.1 GenPept UniProtKB/Swiss-Prot:Q9D9F8

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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