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Prss59 serine protease 59 [ Mus musculus (house mouse) ]

Gene ID: 73481, updated on 8-Feb-2024

Summary

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Official Symbol
Prss59provided by MGI
Official Full Name
serine protease 59provided by MGI
Primary source
MGI:MGI:1920731
See related
Ensembl:ENSMUSG00000029883 AllianceGenome:MGI:1920731
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Tryx5; 1700074P13Rik
Summary
Located in Golgi apparatus. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Restricted expression toward testis adult (RPKM 86.3) See more
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Genomic context

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See Prss59 in Genome Data Viewer
Location:
6 B1; 6 18.97 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (40897371..40917975, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (40920437..40941041, complement)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_15690 Neighboring gene serine protease 58 Neighboring gene T cell receptor beta, variable 1 Neighboring gene RIKEN cDNA 1810009J06 gene Neighboring gene T cell receptor beta chain Neighboring gene trypsinogen pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Male fertility in Mus musculus requires the activity of TRYX5 in sperm migration into the oviduct. Zhang H, et al. J Cell Physiol, 2020 Sep. PMID 32020604
  2. Integrative characterization of germ cell-specific genes from mouse spermatocyte UniGene library. Choi E, et al. BMC Genomics, 2007 Jul 28. PMID 17662146, Free PMC Article
  3. A genomic analysis of rat proteases and protease inhibitors. Puente XS, et al. Genome Res, 2004 Apr. PMID 15060002, Free PMC Article
  4. Functional genomic landscape of cancer-intrinsic evasion of killing by T cells. Lawson KA, et al. Nature, 2020 Oct. PMID 32968282, Free PMC Article
  5. Fancd2 in vivo interaction network reveals a non-canonical role in mitochondrial function. Zhang T, et al. Sci Rep, 2017 Apr 5. PMID 28378742, Free PMC Article

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Male fertility in Mus musculus requires the activity of TRYX5 in sperm migration into the oviduct.
    Title: Male fertility in Mus musculus requires the activity of TRYX5 in sperm migration into the oviduct.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 
  • Endonuclease-mediated (3)  1 citation

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Component Evidence Code Pubs
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in secretory granule IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
trypsin X5
Names
protease, serine 59

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_006980.1 

    Range
    29643..49763 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001361930.1 → NP_001348859.1  trypsin X5 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same protein.
    Source sequence(s)
    AC161768, BC061035
    Consensus CDS
    CCDS20041.1
    UniProtKB/TrEMBL
    Q9D9G7
    Related
    ENSMUSP00000112987.2, ENSMUST00000122181.8
    Conserved Domains (1) summary
    cl21584
    Location:37 → 244
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

  2. NM_028550.4 → NP_082826.1  trypsin X5 precursor

    See identical proteins and their annotated locations for NP_082826.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 both encode the same protein.
    Source sequence(s)
    AC161768, AK030264, BC061035
    Consensus CDS
    CCDS20041.1
    UniProtKB/TrEMBL
    Q9D9G7
    Related
    ENSMUSP00000031935.4, ENSMUST00000031935.10
    Conserved Domains (1) summary
    cl21584
    Location:37 → 244
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    40897371..40917975 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006506693.4 → XP_006506756.1  trypsin X5 isoform X2

    See identical proteins and their annotated locations for XP_006506756.1

    Conserved Domains (1) summary
    cl21584
    Location:36 → 243
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

  2. XM_030255627.1 → XP_030111487.1  trypsin X5 isoform X1

    UniProtKB/TrEMBL
    Q9D9G7
    Conserved Domains (1) summary
    cl21584
    Location:37 → 244
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

  3. XM_030255628.1 → XP_030111488.1  trypsin X5 isoform X1

    UniProtKB/TrEMBL
    Q9D9G7
    Conserved Domains (1) summary
    cl21584
    Location:37 → 244
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

  4. XM_017321780.2 → XP_017177269.1  trypsin X5 isoform X1

    UniProtKB/TrEMBL
    Q9D9G7
    Conserved Domains (1) summary
    cl21584
    Location:37 → 244
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

  5. XM_017321779.2 → XP_017177268.1  trypsin X5 isoform X1

    UniProtKB/TrEMBL
    Q9D9G7
    Conserved Domains (1) summary
    cl21584
    Location:37 → 244
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

  6. XM_017321778.2 → XP_017177267.1  trypsin X5 isoform X1

    UniProtKB/TrEMBL
    Q9D9G7
    Conserved Domains (1) summary
    cl21584
    Location:37 → 244
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

  7. XM_030255629.1 → XP_030111489.1  trypsin X5 isoform X1

    UniProtKB/TrEMBL
    Q9D9G7
    Conserved Domains (1) summary
    cl21584
    Location:37 → 244
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

  8. XM_030255633.1 → XP_030111493.1  trypsin X5 isoform X2

    Conserved Domains (1) summary
    cl21584
    Location:36 → 243
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

  9. XM_030255630.1 → XP_030111490.1  trypsin X5 isoform X2

    Conserved Domains (1) summary
    cl21584
    Location:36 → 243
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

  10. XM_030255632.1 → XP_030111492.1  trypsin X5 isoform X2

    Conserved Domains (1) summary
    cl21584
    Location:36 → 243
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

  11. XM_030255631.1 → XP_030111491.1  trypsin X5 isoform X2

    Conserved Domains (1) summary
    cl21584
    Location:36 → 243
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

  12. XM_011241489.4 → XP_011239791.1  trypsin X5 isoform X2

    See identical proteins and their annotated locations for XP_011239791.1

    Conserved Domains (1) summary
    cl21584
    Location:36 → 243
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

  13. XM_011241488.3 → XP_011239790.1  trypsin X5 isoform X1

    See identical proteins and their annotated locations for XP_011239790.1

    UniProtKB/TrEMBL
    Q9D9G7
    Conserved Domains (1) summary
    cl21584
    Location:37 → 244
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
Nucleotide Protein Strain
Heading Accession and Version

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