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Spata18 spermatogenesis associated 18 [ Mus musculus (house mouse) ]

Gene ID: 73472, updated on 5-Mar-2024

Summary

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Official Symbol
Spata18provided by MGI
Official Full Name
spermatogenesis associated 18provided by MGI
Primary source
MGI:MGI:1920722
See related
Ensembl:ENSMUSG00000029155 AllianceGenome:MGI:1920722
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Mieap; 1700067I02Rik
Summary
Predicted to enable identical protein binding activity. Predicted to be involved in cellular response to DNA damage stimulus; mitochondrial protein catabolic process; and mitophagy by induced vacuole formation. Predicted to act upstream of or within cell differentiation and spermatogenesis. Predicted to be located in mitochondrion and sperm flagellum. Predicted to be active in mitochondrial outer membrane. Orthologous to human SPATA18 (spermatogenesis associated 18). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Restricted expression toward testis adult (RPKM 188.6) See more
Orthologs
human all
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Genomic context

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See Spata18 in Genome Data Viewer
Location:
5 C3.3; 5 39.03 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (73808723..73836927)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (73651380..73679584)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene leucine rich repeat containing 66 Neighboring gene STARR-seq mESC enhancer starr_13389 Neighboring gene sarcoglycan, beta (dystrophin-associated glycoprotein) Neighboring gene predicted gene, 34902 Neighboring gene STARR-seq mESC enhancer starr_13390 Neighboring gene predicted gene, 34960 Neighboring gene STARR-seq mESC enhancer starr_13392 Neighboring gene STARR-seq mESC enhancer starr_13393 Neighboring gene RIKEN cDNA 1700019F05 gene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. DNA damage invokes mitophagy through a pathway involving Spata18. Dan X, et al. Nucleic Acids Res, 2020 Jul 9. PMID 32453416, Free PMC Article
  2. Mieap suppresses murine intestinal tumor via its mitochondrial quality control. Tsuneki M, et al. Sci Rep, 2015 Jul 28. PMID 26216032, Free PMC Article
  3. MIEAP and ATG5 are tumor suppressors in a mouse model of BRAF(V600E)-positive thyroid cancer. Hamada K, et al. Front Endocrinol (Lausanne), 2022. PMID 36187114, Free PMC Article
  4. SPATA18, a spermatogenesis-associated gene, is a novel transcriptional target of p53 and p63. Bornstein C, et al. Mol Cell Biol, 2011 Apr. PMID 21300779, Free PMC Article
  5. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. MIEAP and ATG5 are tumor suppressors in a mouse model of BRAF(V600E)-positive thyroid cancer.
    Title: MIEAP and ATG5 are tumor suppressors in a mouse model of BRAF(V600E)-positive thyroid cancer.
  2. findings suggest that the Mieap-regulated mitochondrial quality control plays a critical role in preventing mouse intestinal tumorigenesis.
    Title: Mieap suppresses murine intestinal tumor via its mitochondrial quality control.
  3. DNA damage invokes mitophagy through a pathway involving Spata18.
    Title: DNA damage invokes mitophagy through a pathway involving Spata18.
  4. show that SPATA18 transcription is induced by p53 in a variety of cell types of both human and mouse origin
    Title: SPATA18, a spermatogenesis-associated gene, is a novel transcriptional target of p53 and p63.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1)  1 citation
  • Endonuclease-mediated (1) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in DNA damage response ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within cell differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in mitochondrial protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitochondrial protein catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in mitophagy by internal vacuole formation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitophagy by internal vacuole formation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within multicellular organism development IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within spermatogenesis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in mitochondrial outer membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrial outer membrane ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  
located_in sperm flagellum ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
mitochondria-eating protein
Names
spermatogenesis associated 18 homolog
spermatogenesis-associated protein 18

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_178387.3 → NP_848474.2  mitochondria-eating protein

    See identical proteins and their annotated locations for NP_848474.2

    Status: VALIDATED

    Source sequence(s)
    AC140429
    Consensus CDS
    CCDS57351.1
    UniProtKB/Swiss-Prot
    B7ZMP4, Q0P557
    UniProtKB/TrEMBL
    E9QAP8
    Related
    ENSMUSP00000064308.8, ENSMUST00000071077.14
    Conserved Domains (1) summary
    pfam16026
    Location:296 → 484
    MIEAP; Mitochondria-eating protein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    73808723..73836927
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006504155.3 → XP_006504218.1  mitochondria-eating protein isoform X1

    UniProtKB/TrEMBL
    E9QAP8
    Conserved Domains (3) summary
    TIGR02168
    Location:118 → 238
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam16026
    Location:296 → 484
    MIEAP; Mitochondria-eating protein
    pfam12128
    Location:12 → 211
    DUF3584; Protein of unknown function (DUF3584)

  2. XM_006504159.3 → XP_006504222.1  mitochondria-eating protein isoform X2

    UniProtKB/TrEMBL
    E9QAP8
    Conserved Domains (2) summary
    pfam16026
    Location:264 → 452
    MIEAP; Mitochondria-eating protein
    pfam17045
    Location:128 → 218
    CEP63; Centrosomal protein of 63 kDa

  3. XM_006504160.3 → XP_006504223.1  mitochondria-eating protein isoform X3

    UniProtKB/TrEMBL
    E9QAP8
    Related
    ENSMUSP00000040922.10, ENSMUST00000041422.15
    Conserved Domains (1) summary
    pfam16026
    Location:264 → 452
    MIEAP; Mitochondria-eating protein

RNA

  1. XR_003955716.1 RNA Sequence

  2. XR_001784752.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q0P557.2 GenPept UniProtKB/Swiss-Prot:Q0P557

Gene LinkOut

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