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Kif2b kinesin family member 2B [ Mus musculus (house mouse) ]

Gene ID: 73470, updated on 11-Apr-2024

Summary

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Official Symbol
Kif2bprovided by MGI
Official Full Name
kinesin family member 2Bprovided by MGI
Primary source
MGI:MGI:1920720
See related
Ensembl:ENSMUSG00000046755 AllianceGenome:MGI:1920720
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
1700063D03Rik
Summary
Predicted to enable ATP hydrolysis activity; microtubule binding activity; and microtubule motor activity. Predicted to be involved in several processes, including metaphase plate congression; microtubule depolymerization; and regulation of chromosome segregation. Predicted to act upstream of or within cell division. Predicted to be located in intercellular bridge; mitotic spindle; and nucleolus. Predicted to be part of kinesin complex. Predicted to be active in centrosome; microtubule; and spindle. Orthologous to human KIF2B (kinesin family member 2B). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human all
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Genomic context

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Location:
11 D; 11 56.1 cM
Exon count:
1
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (91466112..91468381, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (91575286..91577555, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 4930405D11 gene Neighboring gene STARR-seq mESC enhancer starr_30416 Neighboring gene STARR-seq mESC enhancer starr_30417 Neighboring gene STARR-seq mESC enhancer starr_30418 Neighboring gene STARR-seq mESC enhancer starr_30419 Neighboring gene STARR-seq mESC enhancer starr_30420 Neighboring gene chaperonin containing Tcp1, subunit 3 (gamma) pseudogene Neighboring gene STARR-seq mESC enhancer starr_30422 Neighboring gene STARR-seq mESC enhancer starr_30425 Neighboring gene STARR-seq mESC enhancer starr_30426 Neighboring gene STARR-seq mESC enhancer starr_30427 Neighboring gene STARR-seq mESC enhancer starr_30428 Neighboring gene predicted gene, 38950 Neighboring gene STARR-seq mESC enhancer starr_30429 Neighboring gene STARR-seq mESC enhancer starr_30430 Neighboring gene STARR-seq mESC enhancer starr_30431 Neighboring gene crumbs homolog 1 pseudogene Neighboring gene ribosomal protein L15 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Genome engineering uncovers 54 evolutionarily conserved and testis-enriched genes that are not required for male fertility in mice. Miyata H, et al. Proc Natl Acad Sci U S A, 2016 Jul 12. PMID 27357688, Free PMC Article
  2. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
  3. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
  4. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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General gene information

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Homology

Clone Names

  • MGC118316

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables microtubule binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables microtubule motor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within cell cycle IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within cell division IEA
Inferred from Electronic Annotation
more info
  
involved_in metaphase chromosome alignment ISO
Inferred from Sequence Orthology
more info
  
involved_in microtubule depolymerization ISO
Inferred from Sequence Orthology
more info
  
involved_in microtubule-based movement IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of chromosome segregation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in centrosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in chromosome IEA
Inferred from Electronic Annotation
more info
  
located_in chromosome, centromeric region IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in intercellular bridge ISO
Inferred from Sequence Orthology
more info
  
part_of kinesin complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in kinetochore IEA
Inferred from Electronic Annotation
more info
  
is_active_in microtubule IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in microtubule cytoskeleton ISO
Inferred from Sequence Orthology
more info
  
located_in mitotic spindle ISO
Inferred from Sequence Orthology
more info
  
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  
is_active_in spindle IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
kinesin-like protein KIF2B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_028547.3 → NP_082823.1  kinesin-like protein KIF2B

    See identical proteins and their annotated locations for NP_082823.1

    Status: VALIDATED

    Source sequence(s)
    AL662779
    Consensus CDS
    CCDS36281.1
    UniProtKB/Swiss-Prot
    Q8C0N1
    UniProtKB/TrEMBL
    A2RSC8
    Related
    ENSMUSP00000058084.5, ENSMUST00000061019.6
    Conserved Domains (2) summary
    cd01367
    Location:213 → 541
    KISc_KIF2_like; Kinesin motor domain, KIF2-like group
    pfam00225
    Location:219 → 542
    Kinesin; Kinesin motor domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    91466112..91468381 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8C0N1.1 GenPept UniProtKB/Swiss-Prot:Q8C0N1

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
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