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Zfp974 zinc finger protein 974 [ Mus musculus (house mouse) ]

Gene ID: 73430, updated on 8-Feb-2024

Summary

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Official Symbol
Zfp974provided by MGI
Official Full Name
zinc finger protein 974provided by MGI
Primary source
MGI:MGI:1920680
See related
Ensembl:ENSMUSG00000070709 AllianceGenome:MGI:1920680
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
1700049G17Rik
Summary
Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in bladder; testis; ureter; and urethra of male. Orthologous to human ZNF780B (zinc finger protein 780B). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in bladder adult (RPKM 1.9), CNS E18 (RPKM 1.6) and 20 other tissues See more
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Genomic context

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Location:
7 A3; 7 15.97 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (27604839..27629124, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (27905414..27929699, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_18392 Neighboring gene zinc finger protein 59 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:28645358-28645700 Neighboring gene zinc finger protein 607A Neighboring gene STARR-seq mESC enhancer starr_18395 Neighboring gene protein kinase C, zeta 2 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:28718534-28718717 Neighboring gene STARR-positive B cell enhancer ABC_E4911 Neighboring gene predicted gene, 26891 Neighboring gene predicted gene, 53355 Neighboring gene Josephin domain containing 1, pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Mouse brain organization revealed through direct genome-scale TF expression analysis. Gray PA, et al. Science, 2004 Dec 24. PMID 15618518
  2. GUDMAP: the genitourinary developmental molecular anatomy project. McMahon AP, et al. J Am Soc Nephrol, 2008 Apr. PMID 18287559
  3. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
  4. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article
  5. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA-binding transcription activator activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
zinc finger protein 974

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001374027.1 → NP_001360956.1  zinc finger protein 974 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC139063
    UniProtKB/TrEMBL
    B9EJ82
    Conserved Domains (3) summary
    smart00349
    Location:14 → 75
    KRAB; krueppel associated box
    COG5048
    Location:199 → 574
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:417 → 437
    ZF_C2H2; C2H2 Zn finger [structural motif]

  2. NM_028538.3 → NP_082814.1  zinc finger protein 974 isoform 2

    See identical proteins and their annotated locations for NP_082814.1

    Status: VALIDATED

    Source sequence(s)
    AC139063
    Consensus CDS
    CCDS21032.1
    UniProtKB/TrEMBL
    Q3UVF6
    Related
    ENSMUSP00000096238.3, ENSMUST00000098639.9
    Conserved Domains (2) summary
    COG5048
    Location:125 → 500
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:343 → 363
    ZF_C2H2; C2H2 Zn finger [structural motif]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    27604839..27629124 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036153468.1 → XP_036009361.1  zinc finger protein 974 isoform X2

    UniProtKB/TrEMBL
    Q3UVF6
    Conserved Domains (2) summary
    COG5048
    Location:125 → 500
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:343 → 363
    ZF_C2H2; C2H2 Zn finger [structural motif]

  2. XM_030243021.1 → XP_030098881.1  zinc finger protein 974 isoform X1

    UniProtKB/TrEMBL
    B9EJ82
    Conserved Domains (3) summary
    smart00349
    Location:14 → 75
    KRAB; krueppel associated box
    COG5048
    Location:199 → 574
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:417 → 437
    ZF_C2H2; C2H2 Zn finger [structural motif]

  3. XM_030243020.2 → XP_030098880.1  zinc finger protein 974 isoform X1

    UniProtKB/TrEMBL
    B9EJ82
    Conserved Domains (3) summary
    smart00349
    Location:14 → 75
    KRAB; krueppel associated box
    COG5048
    Location:199 → 574
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:417 → 437
    ZF_C2H2; C2H2 Zn finger [structural motif]
Nucleotide Protein Strain
Heading Accession and Version

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