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Prox2 prospero homeobox 2 [ Mus musculus (house mouse) ]

Gene ID: 73422, updated on 11-Apr-2024

Summary

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Official Symbol
Prox2provided by MGI
Official Full Name
prospero homeobox 2provided by MGI
Primary source
MGI:MGI:1920672
See related
Ensembl:ENSMUSG00000042320 AllianceGenome:MGI:1920672
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
1700058C01Rik
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in brain; central nervous system ganglion; and genitourinary system. Orthologous to human PROX2 (prospero homeobox 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in testis adult (RPKM 8.5), cortex adult (RPKM 2.0) and 19 other tissues See more
Orthologs
human all
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Genomic context

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See Prox2 in Genome Data Viewer
Location:
12 D1; 12 39.54 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (85132584..85157606, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (85085810..85110885, complement)

Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr12:86311736-86311923 Neighboring gene FCF1 rRNA processing protein Neighboring gene STARR-positive B cell enhancer ABC_E1446 Neighboring gene STARR-seq mESC enhancer starr_32760 Neighboring gene YLP motif containing 1 Neighboring gene STARR-seq mESC enhancer starr_32761 Neighboring gene STARR-seq mESC enhancer starr_32762 Neighboring gene prospero homeobox 2 opposite strand Neighboring gene CapStarr-seq enhancer MGSCv37_chr12:86464102-86464289 Neighboring gene dihydrolipoamide S-succinyltransferase Neighboring gene ribosomal protein S6 kinase-like 1 Neighboring gene STARR-seq mESC enhancer starr_32766 Neighboring gene placental growth factor

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Characterization of a novel prospero-related homeobox gene, Prox2. Nishijima I, et al. Mol Genet Genomics, 2006 May. PMID 16470382
  2. Prox1 interacts with Atoh1 and Gfi1, and regulates cellular differentiation in the inner ear sensory epithelia. Kirjavainen A, et al. Dev Biol, 2008 Oct 1. PMID 18652815
  3. Visceral motor neuron diversity delineates a cellular basis for nipple- and pilo-erection muscle control. Furlan A, et al. Nat Neurosci, 2016 Oct. PMID 27571008
  4. Brn3a regulates the transition from neurogenesis to terminal differentiation and represses non-neural gene expression in the trigeminal ganglion. Lanier J, et al. Dev Dyn, 2009 Dec. PMID 19877281, Free PMC Article
  5. Interactome mapping of the phosphatidylinositol 3-kinase-mammalian target of rapamycin pathway identifies deformed epidermal autoregulatory factor-1 as a new glycogen synthase kinase-3 interactor. Pilot-Storck F, et al. Mol Cell Proteomics, 2010 Jul. PMID 20368287, Free PMC Article

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Prox2 and Runx3 vagal sensory neurons regulate esophageal motility.
    Title: Prox2 and Runx3 vagal sensory neurons regulate esophageal motility.
  2. Compared to mouse Prox1, mouse Prox2 is dispensable for embryonic development, retinal horizontal cell generation, and fertility.
    Title: Characterization of a novel prospero-related homeobox gene, Prox2.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • 1700058C01Rik

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
prospero homeobox protein 2
Names
homeobox prospero-like protein PROX2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001361238.1 → NP_001348167.1  prospero homeobox protein 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and represents use of an alternate promoter, compared to variant 1. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AC127582, AK029978
    Consensus CDS
    CCDS36495.1
    UniProtKB/Swiss-Prot
    Q8BII1
    Related
    ENSMUSP00000135881.2, ENSMUST00000177289.9
    Conserved Domains (2) summary
    PHA03247
    Location:27 → 443
    PHA03247; large tegument protein UL36; Provisional
    pfam05044
    Location:435 → 586
    HPD; Homeo-prospero domain

  2. NM_001361239.2 → NP_001348168.1  prospero homeobox protein 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' and 3' UTRs compared to variant 1. Variants 1, 2, and 3 encode the same protein.
    Source sequence(s)
    AC127582
    Consensus CDS
    CCDS36495.1
    UniProtKB/Swiss-Prot
    Q8BII1
    Conserved Domains (2) summary
    PHA03247
    Location:27 → 443
    PHA03247; large tegument protein UL36; Provisional
    pfam05044
    Location:435 → 586
    HPD; Homeo-prospero domain

  3. NM_175198.6 → NP_780407.1  prospero homeobox protein 2

    See identical proteins and their annotated locations for NP_780407.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AC127582
    Consensus CDS
    CCDS36495.1
    UniProtKB/Swiss-Prot
    Q8BII1
    Related
    ENSMUSP00000105878.3, ENSMUST00000110249.3
    Conserved Domains (2) summary
    PHA03247
    Location:27 → 443
    PHA03247; large tegument protein UL36; Provisional
    pfam05044
    Location:435 → 586
    HPD; Homeo-prospero domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000078.7 Reference GRCm39 C57BL/6J

    Range
    85132584..85157606 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006516281.5 → XP_006516344.1  prospero homeobox protein 2 isoform X1

    See identical proteins and their annotated locations for XP_006516344.1

    UniProtKB/Swiss-Prot
    Q8BII1
    Conserved Domains (2) summary
    PHA03247
    Location:27 → 443
    PHA03247; large tegument protein UL36; Provisional
    pfam05044
    Location:435 → 586
    HPD; Homeo-prospero domain

  2. XM_030246952.2 → XP_030102812.1  prospero homeobox protein 2 isoform X1

    UniProtKB/Swiss-Prot
    Q8BII1
    Conserved Domains (2) summary
    PHA03247
    Location:27 → 443
    PHA03247; large tegument protein UL36; Provisional
    pfam05044
    Location:435 → 586
    HPD; Homeo-prospero domain

  3. XM_017315213.3 → XP_017170702.2  prospero homeobox protein 2 isoform X1

    UniProtKB/Swiss-Prot
    Q8BII1
    Conserved Domains (2) summary
    PHA03247
    Location:27 → 443
    PHA03247; large tegument protein UL36; Provisional
    pfam05044
    Location:435 → 586
    HPD; Homeo-prospero domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BII1.1 GenPept UniProtKB/Swiss-Prot:Q8BII1

Gene LinkOut

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