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Msl3l2 MSL3 like 2 [ Mus musculus (house mouse) ]

Gene ID: 73390, updated on 8-Feb-2024

Summary

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Official Symbol
Msl3l2provided by MGI
Official Full Name
MSL3 like 2provided by MGI
Primary source
MGI:MGI:1920640
See related
Ensembl:ENSMUSG00000047669 AllianceGenome:MGI:1920640
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
1700060H10Rik
Summary
Predicted to enable DNA binding activity; histone acetyltransferase activity (H4-K16 specific); and methylated histone binding activity. Predicted to be involved in heterochromatin assembly and histone modification. Predicted to be located in nucleus. Predicted to be part of MSL complex and NuA4 histone acetyltransferase complex. Human ortholog(s) of this gene implicated in Basilicata-Akhtar syndrome. Orthologous to several human genes including MSL3 (MSL complex subunit 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in testis adult (RPKM 35.3), ovary adult (RPKM 7.3) and 14 other tissues See more
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Genomic context

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Location:
10 B3; 10 28.5 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (55959931..55992976)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (56083835..56116880)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 31849 Neighboring gene putative heat shock protein HSP 90-beta-3 Neighboring gene STARR-seq mESC enhancer starr_26716 Neighboring gene STARR-seq mESC enhancer starr_26717 Neighboring gene STARR-seq mESC enhancer starr_26718 Neighboring gene STARR-seq mESC enhancer starr_26719 Neighboring gene STARR-seq mESC enhancer starr_26720 Neighboring gene STARR-seq mESC enhancer starr_26721 Neighboring gene STARR-seq mESC enhancer starr_26722 Neighboring gene TBC1 domain family, member 32 Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:55826518-55826701 Neighboring gene UPF0183 protein C16orf70 homolog Neighboring gene STARR-positive B cell enhancer ABC_E8334 Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:55948756-55948865 Neighboring gene STARR-seq mESC enhancer starr_26724 Neighboring gene STARR-seq mESC enhancer starr_26725 Neighboring gene STARR-seq mESC enhancer starr_26726 Neighboring gene STARR-seq mESC enhancer starr_26730 Neighboring gene STARR-seq mESC enhancer starr_26731 Neighboring gene STARR-seq mESC enhancer starr_26732 Neighboring gene ribosomal protein S8, pseudogene 1 Neighboring gene gap junction protein, alpha 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58. Yokoyama S, et al. Dev Cell, 2009 Dec. PMID 20059953, Free PMC Article
  2. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article
  3. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
  4. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636
  5. RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer. Shibata K, et al. Genome Res, 2000 Nov. PMID 11076861, Free PMC Article

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Gene Ontology Provided by MGI

Component Evidence Code Pubs
part_of MSL complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of NuA4 histone acetyltransferase complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
male-specific lethal 3-like 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001163833.1 → NP_001157305.1  male-specific lethal 3-like 2

    See identical proteins and their annotated locations for NP_001157305.1

    Status: VALIDATED

    Source sequence(s)
    AC153521
    Consensus CDS
    CCDS48561.1
    UniProtKB/TrEMBL
    G3X992, Q3U2B0
    Related
    ENSMUSP00000051220.8, ENSMUST00000063138.8
    Conserved Domains (1) summary
    pfam05712
    Location:33 → 356
    MRG

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    55959931..55992976
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006512876.4 → XP_006512939.1  male-specific lethal 3-like 2 isoform X1

    See identical proteins and their annotated locations for XP_006512939.1

    UniProtKB/TrEMBL
    G3X992, Q3U2B0
    Conserved Domains (1) summary
    pfam05712
    Location:33 → 356
    MRG

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_133751.1: Suppressed sequence

    Description
    NM_133751.1: This RefSeq was permanently suppressed because it is now thought that this gene is a pseudogene.

  2. NR_003618.1: Suppressed sequence

    Description
    NR_003618.1: This RefSeq was permanently suppressed because it is now thought that this gene does encode a protein.
Nucleotide Protein Strain
Heading Accession and Version

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