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Dcbld2 discoidin, CUB and LCCL domain containing 2 [ Mus musculus (house mouse) ]

Gene ID: 73379, updated on 11-Apr-2024

Summary

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Official Symbol
Dcbld2provided by MGI
Official Full Name
discoidin, CUB and LCCL domain containing 2provided by MGI
Primary source
MGI:MGI:1920629
See related
Ensembl:ENSMUSG00000035107 AllianceGenome:MGI:1920629
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Esdn; CLCP1; 1700055P21Rik
Summary
Predicted to be involved in negative regulation of cell growth and wound healing. Predicted to be located in cell surface. Predicted to be integral component of plasma membrane. Orthologous to human DCBLD2 (discoidin, CUB and LCCL domain containing 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in bladder adult (RPKM 10.6), CNS E11.5 (RPKM 10.5) and 27 other tissues See more
Orthologs
human all
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Genomic context

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Location:
16 C1.2; 16 34.52 cM
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (58228789..58304013)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (58408535..58469745)

Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 57639 Neighboring gene STARR-seq mESC enhancer starr_41093 Neighboring gene predicted gene, 41463 Neighboring gene STARR-seq mESC enhancer starr_41094 Neighboring gene STARR-seq mESC enhancer starr_41095 Neighboring gene RIKEN cDNA 4930461C15 gene Neighboring gene STARR-positive B cell enhancer ABC_E1928 Neighboring gene STARR-seq mESC enhancer starr_41096 Neighboring gene STARR-positive B cell enhancer ABC_E3167 Neighboring gene STARR-positive B cell enhancer ABC_E8639 Neighboring gene STARR-positive B cell enhancer ABC_E3168 Neighboring gene ST3 beta-galactoside alpha-2,3-sialyltransferase 6 Neighboring gene STARR-seq mESC enhancer starr_41097 Neighboring gene STARR-seq mESC enhancer starr_41098 Neighboring gene predicted gene, 20942 Neighboring gene ferritin domain containing 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. DCBLD2 regulates vascular hyperplasia by modulating the platelet derived growth factor receptor-β endocytosis through Caveolin-1 in vascular smooth muscle cells. Wang S, et al. FASEB J, 2022 Sep. PMID 35929441
  2. The neuropilin-like protein ESDN regulates insulin signaling and sensitivity. Li X, et al. Am J Physiol Heart Circ Physiol, 2016 May 1. PMID 26921437, Free PMC Article
  3. ESDN inhibits melanoma progression by blocking E-selectin expression in endothelial cells via STAT3. Coppo R, et al. Cancer Lett, 2021 Jul 10. PMID 33862151, Free PMC Article
  4. Transmembrane protein ESDN promotes endothelial VEGF signaling and regulates angiogenesis. Nie L, et al. J Clin Invest, 2013 Dec. PMID 24177422, Free PMC Article
  5. ESDN, a novel neuropilin-like membrane protein cloned from vascular cells with the longest secretory signal sequence among eukaryotes, is up-regulated after vascular injury. Kobuke K, et al. J Biol Chem, 2001 Sep 7. PMID 11447234

See all (25) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. CircDCBLD2 alleviates liver fibrosis by regulating ferroptosis via facilitating STUB1-mediated PARK7 ubiquitination degradation.
    Title: CircDCBLD2 alleviates liver fibrosis by regulating ferroptosis via facilitating STUB1-mediated PARK7 ubiquitination degradation.
  2. DCBLD2 regulates vascular hyperplasia by modulating the platelet derived growth factor receptor-beta endocytosis through Caveolin-1 in vascular smooth muscle cells.
    Title: DCBLD2 regulates vascular hyperplasia by modulating the platelet derived growth factor receptor-β endocytosis through Caveolin-1 in vascular smooth muscle cells.
  3. ESDN regulates insulin signaling and subsequently a wide array of insulin effects in cultured cells and in vivo through modulation of IR interaction with APS and Grb10.
    Title: The neuropilin-like protein ESDN regulates insulin signaling and sensitivity.
  4. Deletion of Esdn in the mouse interfered with adult and developmental angiogenesis.
    Title: Transmembrane protein ESDN promotes endothelial VEGF signaling and regulates angiogenesis.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables signaling receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in negative regulation of cell growth ISO
Inferred from Sequence Orthology
more info
  
involved_in wound healing IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in wound healing ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cell surface ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
discoidin, CUB and LCCL domain-containing protein 2
Names
endothelial and smooth muscle cell-derived neuropilin-like protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001356484.1 → NP_001343413.1  discoidin, CUB and LCCL domain-containing protein 2 isoform 2 precursor

    Status: VALIDATED

    Source sequence(s)
    CT027564
    Conserved Domains (3) summary
    cd00041
    Location:69 → 183
    CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
    cd00057
    Location:293 → 445
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
    cl02694
    Location:190 → 272
    LCCL; LCCL domain

  2. NM_028523.3 → NP_082799.2  discoidin, CUB and LCCL domain-containing protein 2 isoform 1 precursor

    See identical proteins and their annotated locations for NP_082799.2

    Status: VALIDATED

    Source sequence(s)
    AK043915, AK051889, AK052189, BC066097, CAAA01184608
    Consensus CDS
    CCDS28229.1
    UniProtKB/Swiss-Prot
    A6X950, Q8BKI4, Q91ZV3
    Related
    ENSMUSP00000039915.8, ENSMUST00000046663.8
    Conserved Domains (4) summary
    smart00231
    Location:288 → 446
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain
    cd00041
    Location:69 → 183
    CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
    cd00057
    Location:293 → 445
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
    cl02694
    Location:190 → 272
    LCCL; LCCL domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000082.7 Reference GRCm39 C57BL/6J

    Range
    58228789..58304013
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036160148.1 → XP_036016041.1  discoidin, CUB and LCCL domain-containing protein 2 isoform X1

    Conserved Domains (3) summary
    cd00041
    Location:69 → 183
    CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
    cl25480
    Location:293 → 400
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
    cl02694
    Location:190 → 272
    LCCL; LCCL domain

  2. XM_036160149.1 → XP_036016042.1  discoidin, CUB and LCCL domain-containing protein 2 isoform X2

    Conserved Domains (3) summary
    cd00041
    Location:69 → 183
    CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
    cl25480
    Location:293 → 400
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
    cl02694
    Location:190 → 272
    LCCL; LCCL domain

  3. XM_011246022.3 → XP_011244324.1  discoidin, CUB and LCCL domain-containing protein 2 isoform X3

    Conserved Domains (3) summary
    cd00057
    Location:217 → 369
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
    cl00049
    Location:66 → 107
    CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
    cl02694
    Location:114 → 196
    LCCL; LCCL domain

RNA

  1. XR_004939243.1 RNA Sequence

  2. XR_004939244.1 RNA Sequence

  3. XR_004939245.1 RNA Sequence

  4. XR_004939246.1 RNA Sequence

  5. XR_004939247.1 RNA Sequence

  6. XR_004939248.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q91ZV3.1 GenPept UniProtKB/Swiss-Prot:Q91ZV3

Gene LinkOut

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