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Actrt1 actin-related protein T1 [ Mus musculus (house mouse) ]

Gene ID: 73360, updated on 21-Apr-2024

Summary

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Official Symbol
Actrt1provided by MGI
Official Full Name
actin-related protein T1provided by MGI
Primary source
MGI:MGI:1920610
See related
Ensembl:ENSMUSG00000046615 AllianceGenome:MGI:1920610
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Arp-T1; 1700061J02Rik
Summary
Predicted to enable chromatin binding activity. Predicted to be involved in negative regulation of transcription, DNA-templated and regulation of smoothened signaling pathway. Predicted to be located in cytoplasm and cytoskeleton. Predicted to be active in nucleus. Orthologous to human ACTRT1 (actin related protein T1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human all
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Genomic context

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Location:
X A4; X 24.54 cM
Exon count:
1
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (45417884..45419222)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (46329007..46330345)

Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene predicted gene, 52478 Neighboring gene RIKEN cDNA 4930515L19 gene Neighboring gene ribosomal protein L32 pseudogene Neighboring gene STARR-seq mESC enhancer starr_47090 Neighboring gene ribosomal protein SA pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Loss of perinuclear theca ACTRT1 causes acrosome detachment and severe male subfertility in mice. Zhang XZ, et al. Development, 2022 Jun 15. PMID 35616329
  2. Pathogenic Variants in ACTRT1 Cause Acephalic Spermatozoa Syndrome. Sha Y, et al. Front Cell Dev Biol, 2021. PMID 34422805, Free PMC Article
  3. Novel actin-related proteins Arp-T1 and Arp-T2 as components of the cytoskeletal calyx of the mammalian sperm head. Heid H, et al. Exp Cell Res, 2002 Oct 1. PMID 12243744
  4. Molecular evolution of the actin family. Goodson HV, et al. J Cell Sci, 2002 Jul 1. PMID 12077353
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Loss of perinuclear theca ACTRT1 causes acrosome detachment and severe male subfertility in mice.
    Title: Loss of perinuclear theca ACTRT1 causes acrosome detachment and severe male subfertility in mice.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

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Markers

Homology

Clone Names

  • MGC144637, MGC144638

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables chromatin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables chromatin binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in negative regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of smoothened signaling pathway ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in actin cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytoskeleton ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
actin-related protein T1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_028514.3 → NP_082790.1  actin-related protein T1

    See identical proteins and their annotated locations for NP_082790.1

    Status: VALIDATED

    Source sequence(s)
    AK006855
    Consensus CDS
    CCDS30102.1
    UniProtKB/Swiss-Prot
    Q9D9J3
    Related
    ENSMUSP00000062570.3, ENSMUST00000059466.3
    Conserved Domains (2) summary
    smart00268
    Location:9 → 376
    ACTIN; Actin
    cl17037
    Location:8 → 376
    NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000086.8 Reference GRCm39 C57BL/6J

    Range
    45417884..45419222
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9D9J3.1 GenPept UniProtKB/Swiss-Prot:Q9D9J3

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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