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Prss44 serine protease 44 [ Mus musculus (house mouse) ]

Gene ID: 73336, updated on 11-Apr-2024

Summary

Official Symbol
Prss44provided by MGI
Official Full Name
serine protease 44provided by MGI
Primary source
MGI:MGI:1920586
See related
Ensembl:ENSMUSG00000032493 AllianceGenome:MGI:1920586
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
79H19A; Tessp4; TESSP-4; 1700036D21Rik
Summary
Predicted to enable serine-type endopeptidase activity. Predicted to be involved in germ cell development; proteolysis; and spermatogenesis. Located in cytoplasm. Orthologous to human PRSS44P (serine protease 44, pseudogene). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Restricted expression toward testis adult (RPKM 10.8) See more
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Genomic context

Location:
9 F2; 9 60.79 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (110642987..110647067)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (110813919..110817999)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 46141 Neighboring gene serine protease 42 Neighboring gene serine protease 43 Neighboring gene serine protease 45

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables peptidase activity IEA
Inferred from Electronic Annotation
more info
 
enables serine-type endopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables serine-type peptidase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in germ cell development IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in proteolysis IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in spermatogenesis IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
serine protease 44
Names
protease, serine 44
serine protease-like 1
testis serine protease 4
testis specific serine protease 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_148940.3NP_683742.2  serine protease 44 precursor

    See identical proteins and their annotated locations for NP_683742.2

    Status: VALIDATED

    Source sequence(s)
    AB162857, AK006612, AU043597
    Consensus CDS
    CCDS40782.1
    UniProtKB/Swiss-Prot
    Q402U7, Q924U6
    Related
    ENSMUSP00000095948.3, ENSMUST00000098345.3
    Conserved Domains (2) summary
    smart00020
    Location:111340
    Tryp_SPc; Trypsin-like serine protease
    cd00190
    Location:112340
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    110642987..110647067
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006512313.3XP_006512376.1  serine protease 44 isoform X1

    Conserved Domains (1) summary
    cd00190
    Location:11239
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
  2. XM_006512314.4XP_006512377.1  serine protease 44 isoform X2

    Conserved Domains (1) summary
    cd00190
    Location:112245
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
  3. XM_017313617.2XP_017169106.1  serine protease 44 isoform X3

    Conserved Domains (1) summary
    cd00190
    Location:112245
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
  4. XM_006512317.1XP_006512380.1  serine protease 44 isoform X4

    See identical proteins and their annotated locations for XP_006512380.1

    Conserved Domains (1) summary
    cd00190
    Location:12177
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
  5. XM_030244649.1XP_030100509.1  serine protease 44 isoform X4

    Conserved Domains (1) summary
    cd00190
    Location:12177
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...